α-Eleostearic acid, a fat from tung and bitter melon seeds, is proposed to clear worn-out cells that build up with age by triggering runaway oxygen damage inside them. Evidence comes only from lab-grown cells and mice, from one research group with a company and patent interest, without independent repetition. No human results have been reported, the pure compound is sold only as a laboratory chemical, and nothing is settled. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Ferritin | 30–300 ng/mL (men), 15–200 ng/mL (women) | Safety check: iron overload would amplify off-target damage |
| Transferrin saturation | 20–50% | Safety check: circulating iron available for oxidation |
| Alanine aminotransferase | 7–55 U/L | Safety check: liver was a rodent target; a rise would stop use |
| Estimated glomerular filtration rate | No established target; track change from own baseline | Safety check: marked rodent kidney senescence shift; a fall would stop use |
| Haemoglobin | 13.5–17.5 g/dL (men), 12.0–15.5 g/dL (women) | Safety check: a fall would signal red-cell damage in enzyme deficiency |
| Low-density lipoprotein cholesterol | No established target; track change from own baseline | Expected to change: raised at very high rodent intakes |
| Triglycerides | No established target; track change from own baseline | Expected to change: rose at very high rodent intake, fell in rodent liver work |
| High-sensitivity C-reactive protein | No established target; track change from own baseline | Expected to change: proxy for inflammatory signalling lowered in rodents |
| Interleukin-6 | No established target; track change from own baseline | Expected to change: lowered in mouse tissue |
Cadence: Baseline before starting; liver enzymes and kidney filtration at six weeks; full panel at three to six months, then every six to twelve months, with an extra check after any dose increase. No biomarker confirms senescent-cell clearance in people.