5-Amino-1MQ for Health & Longevity - Quick Reference Sheet

5-Amino-1MQ for Health & Longevity

Created on 07/15/2026 – Quick Reference based on Evidence Review created using AI4L / Opus 4.8 Audit

An experimental molecule that blocks an enzyme overactive in fat and aging muscle, helping cells retain fuel-and-repair compounds and burn fat. In obese mice it cut fat, improved blood sugar, and eased fatty liver; in old mice it aided muscle recovery. No human studies exist, and it is sold without quality control. (Full Review)

Protocol

Dose
50 mg once daily
Oral capsule; 50–150 mg reported anecdotally
Timing
Morning
Not established; no chronobiology data
Duration
8–12 weeks
Time-limited trial, then reassess; short-term use
Time to effect
Metabolic effects
~4 weeks
Animal dosing; not established in humans

Benefits

Contraindications
  • Pregnancy or breastfeeding
  • Active cancer or cancer surveillance
  • Significant liver or kidney disease
  • Unwillingness to accept zero human safety data
Key Interactions
  • NAD⁺ precursors and vitamin B3 forms (nicotinamide riboside, NMN, niacin, nicotinamide)
  • Methyl-donor supplements (SAMe, betaine, high-dose folate/methylcobalamin)
  • Prescription drugs cleared by methyltransferase pathways (thiopurines, levodopa)
  • Other experimental longevity/metabolic compounds

Risk & Side Effects

  • Low: Unregulated product quality and contamination
  • Speculative: Loss of 1-methylnicotinamide signaling; systemic methylation shifts; reduced xenobiotic clearance; unknown long-term, fertility, and pregnancy safety

Monitoring

Marker Target Why
Fasting glucose 75–90 mg/dL Tracks the glucose-control benefit
Fasting insulin 2–5 µIU/mL Detects insulin-sensitivity change
HbA1c < 5.4% Longer-term glucose average
ALT / AST < 25 U/L (both) Screens for the liver-fat benefit and liver stress/harm
Lipid panel Triglycerides < 80 mg/dL; HDL > 50 mg/dL Animal data show cholesterol and triglyceride reductions
Homocysteine 5–7 µmol/L Watches the methylation pathway the drug alters
hs-CRP < 1.0 mg/L General marker of systemic inflammation

Cadence: Baseline before first dose; reassess at 8–12 weeks, then every 3–6 months if use continues

Qualitative Assessment

  • Energy levels and daytime fatigue
  • Body composition and waist measurement
  • Exercise recovery and strength
  • Cognitive clarity and focus (claimed but unproven)