An experimental oral compound that makes brain cells more responsive to their own growth signals. In laboratory work it protected nerve cells and restored memory in old mice. In healthy volunteers it reached the brain and shifted brain-wave patterns, but never improved memory, mood or function in any person. Safety data are thin; all data come from the compound's owner. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Serum lipase | 13–60 U/L | The one laboratory signal seen in humans |
| Serum amylase | 30–110 U/L | Confirms or refutes a lipase finding |
| ALT | 10–26 U/L (men), 10–19 U/L (women) | Clearance is entirely metabolic, so liver stress matters |
| eGFR | ≥90 mL/min/1.73 m² | Establishes organ reserve before dosing |
| Prolactin | 3–13 ng/mL (men), 3–20 ng/mL (non-pregnant women) | Carried forward from the trial safety panel |
| Serum brain-derived neurotrophic factor | No established target exists; track the change from the individual's own baseline instead | Reflects the pathway being amplified |
Cadence: Pancreatic and liver enzymes on days 1, 4 and 8, then two weeks after the last dose; questionnaires weekly; brain-wave recording at steady state. A longer outpatient schedule would repeat the panel at 4 and 12 weeks, then every 6–12 months.