Agmatine is an inexpensive molecule made from the amino acid arginine that acts on many nerve and blood-vessel systems at once. Its most credible human benefit is short-term relief of nerve-related and disc pain; claims for mood, brain protection, exercise blood flow, metabolism, and longevity rest mainly on animal studies. Short courses seem well tolerated, but long-term safety is unknown. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Blood pressure | ~110–125 / 70–80 mmHg | Can be raised or lowered unpredictably |
| Resting heart rate | 55–70 bpm | Cardiovascular effects can alter heart rate |
| eGFR | >90 mL/min/1.73 m² | Agmatine is cleared by the kidneys |
| Fasting glucose | 75–90 mg/dL | Imidazoline effects may influence glucose |
| BUN | 10–18 mg/dL | Complements eGFR for renal status |
Cadence: Blood pressure and heart rate several times weekly during weeks 1–4; kidney function and fasting glucose at ~3 months, then every 6–12 months for sustained use