Audit: QRS - Angelica sinensis for Health & Longevity

Audit conducted on 16/08/2026 06:48 using AI4L / Opus 5

Iterations

Summary

Items Count
Total 93
Passed 83
Failed 0
N/A 10
Pass Rate 100.00%
  • Total = Passed + Failed + N/A
  • Pass Rate = Passed / (Passed + Failed) × 100
  • N/A items are excluded from the pass rate calculation

1. General Rules

# Description Result Comments
1.1 Every claim, magnitude, label, recommendation, and statement in the QRS is literally supported by content in the source ER. 🟢 Protocol, time-to-effect, benefit, risk, gate, marker and qualitative content all trace to ER lines 150–216, 236–297, 316–347, 369–393, 428–430, 454–477.
1.2 Where the ER uses cautious phrasing (“not formally studied”, “None documented in human trials to date”, “theoretical concern”, “data are limited”), the QRS uses the same phrasing. 🟢 “Blood-thinner interaction unresolved” mirrors ER “neither established nor excluded” (line 501); “hormone-driven tumour growth seen in animals” preserves the animal-model limitation.
1.3 The QRS never strengthens an ER claim (e.g., “not formally studied” → “not required”) or softens one (e.g., “do not use during pregnancy” → “use with caution during pregnancy”). 🟢 Pregnancy, warfarin-INR, platelet and transferrin thresholds carried at ER strength; “Tested alone, the root has repeatedly done nothing” matches ER line 499.
1.4 The QRS does not relabel an ER fact under a different decision category. A “Benefit-Modifying Factor” from ER section is not surfaced as a “Caution”; a “Risk-Modifying Factor” is not surfaced as a “Side Effect”; etc. 🟢 Contraindications come only from the ER avoid list (lines 338–347) plus the ER bullet flagged “(absolute contraindication)”; interactions only from ER lines 318–336.
1.5 PubMed IDs, study citations, expert names, clinical trial identifiers (NCT*), and brand names appear in the QRS only if they appear in the source ER for the same fact. 🟢 No PMIDs, NCT identifiers, author names or brand names in the QRS; the formula names Danggui Buxue Tang / Danggui Shaoyao San / Danggui Sini appear in the ER for the same facts.
1.6 The QRS does not introduce new attributions. 🟢 All attributions (“the dose-escalation trial”, “the renal anemia meta-analysis”, “the glomerulonephritis trial”) are ER attributions for the same facts.

2. Focus, Tone & Audience

# Description Result Comments
2.1 The QRS follows the tone of the ER, which is determined by the ER’s own language, phrasing, and framing. 🟢 Sober, sceptical, formula-versus-root framing matches the ER throughout.
2.2 The tone of the QRS is simultaneously expert, accessible, objective, and data-driven, but also empowering and encouraging 🟢 Quantified doses, thresholds and marker ranges presented neutrally and actionably.
2.3 The QRS reads as a trusted, knowledgeable guide rather than a prescriptive doctor 🟢 Content is stated as evidence and thresholds, not as orders.
2.4 The QRS avoids language that implies medical or clinical advice 🟢 Cadence and gate items are phrased descriptively (“the threshold below which the root is avoided”), not as instructions.
2.5 The QRS “presents information” instead of “providing guidance”, “recommending”, or “advising” 🟢 No “recommended”, “advised” or “should” constructions in the document’s own voice.
2.6 The QRS never addresses “the reader” directly — it presents evidence, not guidance 🟢 No second-person pronouns anywhere in the file.
2.7 The QRS is written in plain language, avoiding unnecessary medical jargon 🟢 “International normalised ratio”, “estimated glomerular filtration rate” and “urine albumin-to-creatinine ratio” are spelled out; remaining technical terms are ER-native and unavoidable.
2.8 Information is presented in a concise and very compact manner 🟢 Gate and tier items are noun phrases; sub-lines are one sentence.
2.9 It DOES NOT address the reader directly 🟢 Confirmed — no “you”/”your”.
2.10 The target audience is health- and longevity-oriented adults who are risk-aware, proactive, and actively seeking to optimize health or apply the intervention under review. 🟢 Biomarker panel, third-party-quality thresholds and interaction gates address a proactive self-managing reader.
2.11 The target audience is willing to employ lifestyle and behavioral changes as well as follow protocols that may be inconvenient, costly, or require effort. 🟢 12-week granule courses, split dosing, repeat lab panels and perioperative washout are presented without hedging on effort.
2.12 The document is NOT written for the general population, who are unwilling to employ lifestyle and behavioral changes or follow protocols that may be inconvenient, costly, or require effort. 🟢 No simplification toward casual consumers; assumes lab access and adherence.
2.13 Framing, takeaways, and risk/benefit weighting throughout the document reflect this audience, including where an intervention’s signal for the average person differs from its signal for this audience. 🟢 At-A-Glance foregrounds that the root alone is inert — the decision-relevant signal for a self-supplementing reader.
2.14 The document’s own voice frames usage in longevity terms, not “anti-aging” (e.g., “anti-aging clinics”, “anti-aging community”, “anti-aging medicine”). Proper names that contain “anti-aging” (e.g., “American Academy of Anti-Aging Medicine”) are quoted verbatim. 🟢 “anti-aging” does not occur; the title uses “Health & Longevity”.
2.15 The document’s own voice uses formal clinical and scientific terminology, not colloquial or consumer-grade language (e.g., “oral medication” not “pill(s)”; “injection” not “shot”; “adverse event” not “bad reaction”). Direct quotes from sources are exempt. 🟢 Clinical register throughout; the two plainer terms in At-A-Glance (“painkillers”, “blood-thinner”) are ER wording (ER lines 42, 499, 501) and required by the At-A-Glance plain-language rule.

3. Template Integrity

# Description Result Comments
3.1 The following labels and headings on the QRS are fixed and not modified: Card and section headings: “Protocol”, “Time to effect”, “Benefits”, “Risk & Side Effects”, “Monitoring”, “Qualitative Assessment”; Gate headings: “Contraindications”, “Key Interactions”; Tier labels: “High”, “Medium”, “Low”, “Speculative”; Table column headers in Monitoring: “Marker”, “Target”, “Why” 🟢 All fixed strings present verbatim at lines 446, 492, 543, 574, 592, 616, 645, 649–651, 786 and in the tier <strong> labels.
3.2 All “” from the [qrs_template] are present in the the QRS. 🟢 64 distinct data-qrs-var spans present with no duplicates: 4 header, 1 at_a_glance, 9 action, 9 time, 4 benefits, stop_items, caution_items, 4 risks, 24 marker, monitoring_cadence, 6 qualitative.
3.3 Spans that are not addressed in a checklist item are left unchanged 🟢 The non-variable website="evidence_review", website="audit" and website="full_review" spans are untouched (lines 423, 426, 440).

4. Formatting

# Description Result Comments
4.1 When the source ER section is empty, the QRS uses the ER’s own empty-state phrasing verbatim. Typical phrasings are “None documented in human trials to date” and “Not formally studied” N/A No source ER section relied on by the QRS is empty.
4.2 Where the ER presents a bulleted item as “Label: content”, the QRS uses the ER’s bold label verbatim as the cell or row label. 🟢 “Standard traditional protocol”, “Trial-derived supplement protocol”, “Single versus split dosing” and all monitoring marker names are ER labels verbatim (ER lines 371, 373, 383, 462–468).
4.3 Labels are not paraphrased, abbreviated, or invented. 🟢 Time-to-effect cell labels derive from the three clauses of the single ER “Time to effect” bullet (line 430), which the template’s three-cell structure requires.
4.4 The QRS DOES NOT use emoji indicators (no 🟩, 🟥, 🟨, etc.). Color and emphasis are conveyed through CSS and bold labels. 🟢 No emoji characters anywhere in the file; tiering is carried by <strong> labels and the CSS palettes.
4.5 The QRS is designed to render on one A4 page. Any section that has more content in the ER than fits the per-section budget is condensed by the LLM, not extended onto a second page. 🟢 Every section is condensed to the template budget: tier lists collapse to one <li> per tier, gate items to single noun phrases, sub-lines to one sentence.

5. Metadata

# Description Result Comments
5.1 The metadata is placed inside a single HTML comment that is the first element after “<!doctype html>” and before any other comment, head, or body content. 🟢 Lines 2–14, immediately after the doctype on line 1.
5.2 Inside that HTML comment the YAML block is delimited by a line “—” opening and a line “—” closing. Text before the opening “—” is permitted but is not parsed as YAML. 🟢 Opening --- at line 3, closing --- at line 13; the preamble text sits on line 2.
5.3 The metadata is not visible in any rendered view of the QRS and is not surfaced by any other element on the sheet. 🟢 Enclosed in an HTML comment; no element echoes its values.
5.4 All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. 🟢 Only duration: "00:03" is quoted, and it contains a colon.
5.5 The filename of the source ER is stated as “er_filename: [er_filename]” 🟢 Line 4: er_filename: angelica_sinensis_2026-0825-0535_Opus_ER.md.
5.6 Version of the QRS.md file used to create the document is stated as “qrs_prompt_version: [Version of QRS.md]” 🟢 Line 5: qrs_prompt_version: 26.7.02, matching the QRS.md version badge.
5.7 Creation date and time of the document is stated as “qrs_creation_date: [YYYY-MMDD-HHMM]” (e.g., 2026-0501-1430) 🟢 Line 6: qrs_creation_date: 2026-0816-0627.
5.8 The nickname of the AI used to create the document is stated as “qrs_creator_ai_nickname: [qrs_creator_ai_nickname]” 🟢 Line 7: qrs_creator_ai_nickname: Opus.
5.9 The nickname of the AI is just a single word model name without version, etc. (e.g., Opus, Sonnet, Grok, Gemini, ChatGPT) 🟢 “Opus” — single word, no version.
5.10 The full name of the AI used to create the document is stated as “qrs_creator_ai_fullname: [qrs_creator_ai_fullname]” 🟢 Line 8: qrs_creator_ai_fullname: Opus 5.
5.11 The full name of the AI consists of the [qrs_creator_ai_nickname] and the model version number and no additional qualifier (e.g., Opus 4.6, Sonnet 3.2, Grok 4.5, Gemini 3.1, ChatGPT 5.4) 🟢 “Opus 5” — nickname plus version, no qualifier.
5.12 The filename of the document is stated as “qrs_filename: [filename of this document]” 🟢 Line 9 matches the on-disk filename exactly.
5.13 All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. 🟢 Re-verified across all eleven keys; only the colon-bearing duration is quoted.

6. Page Title & Header

# Description Result Comments
6.1 [page_title] is set to the [canonical_topic] of the ER frontmatter followed by “ - Quick Reference Sheet” (e.g., “Intervention - Quick Reference Sheet”). The [canonical_topic] is HTML-entity-encoded as needed (e.g., &amp; for &) 🟢 Line 22: “Angelica sinensis for Health & Longevity - Quick Reference Sheet”.
6.2 [header_topic] is set to the [canonical_topic] of the ER frontmatter, with HTML entities encoded as needed (e.g., &amp; for &) 🟢 Line 417: “Angelica sinensis for Health & Longevity”.
6.3 [header_subline_date] is set to [qrs_creation_date reformatted as MM/DD/YYYY] 🟢 Line 421: 08/16/2026, matching qrs_creation_date 2026-0816-0627.
6.4 [header_subline_model] is set to [qrs_creator_ai_fullname] 🟢 Line 425: “Opus 5”.
6.5 No additional header content appears: no badge, version stamp, AKA / alternate names line, source-AI attribution, audit date, or QRS variant marker. 🟢 Header carries only the title and the template subline; the ER’s “Also known as” line is not carried over.

7. At-A-Glance Section

# Description Result Comments
7.1 [at_a_glance] is dense, execution-oriented summary of the ER Conclusion section 🟢 Condenses ER lines 499–503: formula-versus-root verdict, the three positive domains, the null single-herb result, and the two safety signals.
7.2 [at_a_glance] is no longer than 60 words 🟢 58 words.
7.3 Every fact in [at_a_glance] is supported by a distinct passage in the ER. 🟢 Each clause maps to a distinct Conclusion sentence (ER lines 499, 501).
7.4 It DOES NOT use acronyms or technical classifications that require specialist knowledge, uses plain-language terms instead 🟢 Plain renderings used throughout: “kidney-related anemia”, “lung scarring”, “breathing tolerance”, “blood-thinner”, “hormone-driven tumour growth”; no acronyms.
7.5 It DOES NOT cite specific trials (names, years, sample sizes, p-values) 🟢 No trial names, years or sample sizes.
7.6 It DOES NOT cite effect sizes, relative risks, or statistical results 🟢 No numbers of any kind.

8. Contraindications

# Description Result Comments
8.1 The section is derived from the ER Key Interactions & Contraindications section 🟢 All nine items trace to ER lines 326 and 338–347.
8.2 [stop_items] represent the Contraindications from the ER 🟢 All eight ER avoid-bullets are represented, plus the ER interaction bullet flagged “(absolute contraindication)” for tamoxifen and aromatase inhibitors.
8.3 Individual [stop_items] are formatted as <li></li> 🟢 Nine <li> elements at lines 577–587.
8.4 Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. 🟢 ER trailing rationales are stripped (“on uterotonic grounds”, “on absent-safety-data grounds”, “— drugs that shut down the body’s own estrogen production”).
8.5 Parenthetical qualifiers from the ER bullet — time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). 🟢 “(letrozole, anastrozole)”, “particularly the first trimester”, “below 100 × 10⁹/L”, “two weeks before and after”, “above 45%” all retained.
8.6 When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. N/A The ER uses no ranking notation inside parentheses in this section.
8.7 The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no population, condition, or scenario for which the intervention should be avoided, deferred, or used only under specialist supervision. 🟢 The section is populated, and the ER does identify such populations.
8.8 If the section is left empty, an HTML comment inside the [stop_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. N/A The section is not empty.

9. Key Interactions

# Description Result Comments
9.1 The section is derived from the ER Key Interactions & Contraindications section 🟢 All nine items trace to ER lines 318–336.
9.2 [caution_items] represent the Key Interactions from the ER, excluding any that are already listed as Contraindications 🟢 Nine of the ten ER interaction bullets carried; the tamoxifen / aromatase-inhibitor bullet is correctly excluded because it sits in Contraindications.
9.3 Individual [caution_items] are formatted as <li></li> 🟢 Nine <li> elements at lines 595–606.
9.4 Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. 🟢 Every ER mechanism sentence is dropped; only the agent name and severity tag remain.
9.5 Parenthetical qualifiers from the ER bullet — example drug lists, time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). 🟢 Drug lists and severity tags retained and merged into a single paren, e.g. “(apixaban, rivaroxaban, dabigatran; caution)”.
9.6 When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. N/A The ER uses no ranking notation inside parentheses in this section.
9.7 The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no interaction, additive effect, or exposure that changes how the intervention is used. 🟢 The section is populated, and the ER does identify such interactions.
9.8 If the section is left empty, an HTML comment inside the [caution_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. N/A The section is not empty.

10. Protocol

# Description Result Comments
10.1 The section is derived from the ER Protocol section 🟢 Sourced from ER Therapeutic Protocol lines 371, 373, 383.
10.2 The three sets of [action] items cover the three most important actionable implementation aspects from the ER Protocol section 🟢 Dose form and range, the trial-derived effective dose and duration, and dosing frequency — the three bullets that determine what is actually taken.
10.3 If less that three distinct actionable implementation aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. N/A The ER names twelve protocol aspects; all three sets are used.
10.4 All used [action_#label], [action#value], [action#_sub] items are filled with meaningful content derived from the ER Protocol section. 🟢 All nine action spans carry ER-derived content (lines 450–487 of the QRS).

11. Time to Effect

# Description Result Comments
11.1 The three sets of [time] items cover the three most important time-to-effect aspects from the ER 🟢 Menstrual pain (1–3 cycles), anemia and kidney measures (12–24 weeks), and the eight-week minimum — the three clauses of ER line 430.
11.2 The sets are picked and ordered by the magnitude of the related benefit 🟢 Menstrual pain is the ER’s only High-tier benefit and comes first; the Medium/Low kidney and anemia block follows; the general floor is last.
11.3 If less that three distinct time-to-effect aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. N/A Three distinct aspects exist and all three sets are used.
11.4 All used [time_#label], [time#value], [time#_sub] items are filled with meaningful content derived from the ER. 🟢 All nine time spans populated; sub-lines name the ER studies that set each window.
11.5 If the ER does not provide any information on time to effect, the section is removed completely from the Protocol Panel N/A The ER provides time-to-effect information at line 430.

12. Benefits

# Description Result Comments
12.1 The section is derived from the ER Expected Benefits section 🟢 All ten ER benefit headings (lines 154–216) are represented in their original tiers.
12.2 Key variables are [benefits_high], [benefits_medium], [benefits_low], [benefits_speculative] 🟢 All four spans present at lines 545, 548, 555, 562.
12.3 Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. 🟢 Each item is the bare ER benefit heading; no magnitude or mechanism text carried over.
12.4 Parenthetical content — including effect sizes, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. 🟢 No parentheses in any benefit item.
12.5 If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. N/A All four tiers carry items in the ER.

13. Risks

# Description Result Comments
13.1 The section is derived from the ER Potential Risks & Side Effects section 🟢 All nine ER risk headings (lines 240–296) are represented in their original tiers.
13.2 Key variables are [risks_high], [risks_medium], [risks_low], [risks_speculative] 🟢 All four spans present at lines 618, 621, 627, 634.
13.3 Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. 🟢 Each item is the bare ER risk heading; no magnitude text carried over.
13.4 Parenthetical content — including frequencies, severity grades, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. 🟢 No parentheses in any risk item.
13.5 If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. N/A All four tiers carry items in the ER.

14. Monitoring

# Description Result Comments
14.1 The section is derived from the ER Monitoring section 🟢 Marker names, targets and rationales are taken verbatim from the ER Monitoring Protocol & Defining Success table (lines 460–468) and its baseline paragraph (line 456).
14.2 All measurable/quantifiable biomarkers from the Monitoring section are listed 🟢 All seven table biomarkers plus platelet count, which the ER names in the baseline paragraph (“antiplatelet users a platelet count”, line 456).
14.3 [monitoring_cadence] is populated with the monitoring cadence/frequency derived from the ER Monitoring section. It is not left with placeholder text or empty. 🟢 Line 776 condenses ER line 458 (warfarin 1/2/4 weeks then quarterly and after stopping; everyone else 12 weeks then 6-monthly).

15. Qualitative Assessment

# Description Result Comments
15.1 The section is derived from the ER Monitoring section 🟢 Sourced from the ER qualitative-marker list at lines 472–477.
15.2 All subjective/qualitative biomarkers from the Monitoring section are listed 🟢 All six ER qualitative markers are carried verbatim into qualitative_item_1 through qualitative_item_6.

Issues 16/08/2026 06:48

Pass rate 100.00%. No issues found.

Issues 16/08/2026 06:40

  1. 14.2 — Platelet count marker missing: The ER Monitoring section names a platelet count as the baseline measurement for antiplatelet users (ER 456) and sets a numeric threshold of 100 × 10⁹/L (ER 345), but the QRS monitoring table (lines 649–751) omits it and lists only the seven markers from the ER’s table.
  2. 11.4 — Time-to-effect subs restate value: [time_1_sub] (line 504) and [time_2_sub] (line 515) repeat their own label and value word for word (“Menstrual pain … one to three cycles”, “Anemia and kidney … 12 to 24 weeks”) and carry no content beyond them.

Fixes 16/08/2026 06:40

  1. 14.2 — Platelet count marker added: Added a marker_8 row to the monitoring table (Platelet count, “Above 100 × 10⁹/L”, “The baseline measure for antiplatelet users, and the threshold below which the root is avoided”), drawn from ER 456 and the 100 × 10⁹/L threshold at ER 345.
  2. 11.4 — Time-to-effect subs rewritten: Replaced the two subs that merely restated their own label and value with their ER trial sources — [time_1_sub] now reads “Set by the pooled Danggui Shaoyao San and Danggui Sini decoction trials against analgesics” and [time_2_sub] “Set by the renal anemia meta-analysis and the 24-week proteinuria trial in glomerulonephritis”.

Issues 16/08/2026 06:32

  1. 9.5 — Interaction severity classes dropped: Six [caution_items] (QRS lines 590–600) drop the ER’s parenthetical severity class entirely — “(caution)” from direct oral anticoagulants, antiplatelet drugs, estrogen therapy and photosensitising drugs, and “(monitor)” from aspirin/NSAIDs, other blood-moving supplements and sedatives/alcohol — while warfarin and iron supplements retain theirs.

Fixes 16/08/2026 06:32

  1. 9.5 — Interaction severity classes restored: Re-added the ER’s parenthetical severity classes to the seven [caution_items] that had dropped them — “; caution” for direct oral anticoagulants, antiplatelet drugs and photosensitising drugs, “(caution)” for estrogen therapy and hormonal contraceptives, and “; monitor” / “(monitor)” for aspirin and NSAIDs, other blood-moving supplements, and sedatives and alcohol.