Audit: QRS - ATX-304 for Health & Longevity

Audit conducted on 27/08/2026 16:21 using AI4L / Opus 5

Iterations

Summary

Items Count
Total 93
Passed 85
Failed 0
N/A 8
Pass Rate 100.00%
  • Total = Passed + Failed + N/A
  • Pass Rate = Passed / (Passed + Failed) × 100
  • N/A items are excluded from the pass rate calculation

1. General Rules

# Description Result Comments
1.1 Every claim, magnitude, label, recommendation, and statement in the QRS is literally supported by content in the source ER. 🟢 Spot-checked every populated span against the ER: at-a-glance vs ER Conclusion (l.491-493), protocol cells vs ER Therapeutic Protocol (l.353-359), time cells vs ER Practical Considerations (l.412), all 15 monitoring rows vs ER table (l.444-458). All literally supported.
1.2 Where the ER uses cautious phrasing (“not formally studied”, “None documented in human trials to date”, “theoretical concern”, “data are limited”), the QRS uses the same phrasing. 🟢 Cautious ER phrasing carried through, e.g. “Nothing meaningful should be expected inside two weeks” (time_1_sub) and “has never been tested” (action_3_sub) match ER l.412 and l.359.
1.3 The QRS never strengthens an ER claim (e.g., “not formally studied” → “not required”) or softens one (e.g., “do not use during pregnancy” → “use with caution during pregnancy”). 🟢 No strengthening or softening; contraindication thresholds (SBP below 100 mmHg, eGFR below 45, Child-Pugh B or C, MI within 90 days) reproduced at ER strength.
1.4 The QRS does not relabel an ER fact under a different decision category. A “Benefit-Modifying Factor” from ER section is not surfaced as a “Caution”; a “Risk-Modifying Factor” is not surfaced as a “Side Effect”; etc. 🟢 Benefits from ER Expected Benefits, risks from Potential Risks & Side Effects, gates from Key Interactions & Contraindications; no modifying factor is surfaced as a gate.
1.5 PubMed IDs, study citations, expert names, clinical trial identifiers (NCT*), and brand names appear in the QRS only if they appear in the source ER for the same fact. 🟢 No PMIDs, author names, NCT IDs or brand names appear. Generic drug names in the interaction gate (glipizide, semaglutide, etc.) are taken from the same ER bullets (l.296-310).
1.6 The QRS does not introduce new attributions. 🟢 No attributions of any kind appear in the QRS.

2. Focus, Tone & Audience

# Description Result Comments
2.1 The QRS follows the tone of the ER, which is determined by the ER’s own language, phrasing, and framing. 🟢 Matches the ER’s measured, evidence-limited register; the ER’s own “thin record” framing is preserved in at_a_glance.
2.2 The tone of the QRS is simultaneously expert, accessible, objective, and data-driven, but also empowering and encouraging 🟢 Expert and data-driven (targets, thresholds, timing) while remaining accessible; frames what is knowable rather than alarming.
2.3 The QRS reads as a trusted, knowledgeable guide rather than a prescriptive doctor 🟢 Presents trial-derived facts and target ranges; no prescriptive instruction to a patient.
2.4 The QRS avoids language that implies medical or clinical advice 🟢 No advice language; the monitoring cadence is stated as a schedule of measurements, not a directive.
2.5 The QRS “presents information” instead of “providing guidance”, “recommending”, or “advising” 🟢 No “recommend”, “advise” or “should you” constructions anywhere in the body.
2.6 The QRS never addresses “the reader” directly — it presents evidence, not guidance 🟢 No second-person pronouns anywhere in the document body (verified over the whole <body>).
2.7 The QRS is written in plain language, avoiding unnecessary medical jargon 🟢 Plain language throughout; retained abbreviations (HOMA-IR, HbA1c, ALT, eGFR) are the ER’s own biomarker names and are necessary for the monitoring table.
2.8 Information is presented in a concise and very compact manner 🟢 Benefits and risks collapsed to one line per tier; interaction and contraindication bullets stripped to the key fact.
2.9 It DOES NOT address the reader directly 🟢 Confirmed — no direct address.
2.10 The target audience is health- and longevity-oriented adults who are risk-aware, proactive, and actively seeking to optimize health or apply the intervention under review. 🟢 Framing (studied exposures, home monitoring, gray-market sourcing caveat) targets the proactive, risk-aware self-optimizer.
2.11 The target audience is willing to employ lifestyle and behavioral changes as well as follow protocols that may be inconvenient, costly, or require effort. 🟢 Assumes willingness to run a two-week baseline, daily home blood-pressure logging and imaging-based body composition.
2.12 The document is NOT written for the general population, who are unwilling to employ lifestyle and behavioral changes or follow protocols that may be inconvenient, costly, or require effort. 🟢 Not written for the general population; effort-heavy monitoring and investigational-compound framing throughout.
2.13 Framing, takeaways, and risk/benefit weighting throughout the document reflect this audience, including where an intervention’s signal for the average person differs from its signal for this audience. 🟢 The at-a-glance closes on the audience-relevant signal — no repeated result, four-month maximum exposure, company-funded data, no verifiable retail source.
2.14 The document’s own voice frames usage in longevity terms, not “anti-aging” (e.g., “anti-aging clinics”, “anti-aging community”, “anti-aging medicine”). Proper names that contain “anti-aging” (e.g., “American Academy of Anti-Aging Medicine”) are quoted verbatim. 🟢 The term “anti-aging” does not appear; “slowed kidney aging” mirrors the ER’s own benefit heading.
2.15 The document’s own voice uses formal clinical and scientific terminology, not colloquial or consumer-grade language (e.g., “oral medication” not “pill(s)”; “injection” not “shot”; “adverse event” not “bad reaction”). Direct quotes from sources are exempt. 🟢 “Oral medication”, “hypotension”, “treatment-emergent adverse events”, “orthostatic” used in the document’s own voice; the plainer wording in at_a_glance is the ER Conclusion’s own register and is required by item 7.4.

3. Template Integrity

# Description Result Comments
3.1 The following labels and headings on the QRS are fixed and not modified:
• Card and section headings: “Protocol”, “Time to effect”, “Benefits”, “Risk & Side Effects”, “Monitoring”, “Qualitative Assessment”
• Gate headings: “Contraindications”, “Key Interactions”
• Tier labels: “High”, “Medium”, “Low”, “Speculative”
• Table column headers in Monitoring: “Marker”, “Target”, “Why”
🟢 “Protocol”, “Time to effect”, “Benefits”, “Risk & Side Effects”, “Monitoring”, “Qualitative Assessment”, “Contraindications”, “Key Interactions”, tier labels and “Marker / Target / Why” all byte-identical to the template.
3.2 All “” from the [qrs_template] are present in the the QRS. 🟢 All 38 template span names present; marker_#* and qualitative_item# expanded to 15 and 6 numbered instances respectively. No span missing.
3.3 Spans that are not addressed in a checklist item are left unchanged 🟢 Structural diff against the template shows changes only inside data-qrs-var regions and the metadata block; the website=”evidence_review”, website=”audit” and website=”full_review” spans and all CSS are untouched.

4. Formatting

# Description Result Comments
4.1 When the source ER section is empty, the QRS uses the ER’s own empty-state phrasing verbatim. Typical phrasings are “None documented in human trials to date” and “Not formally studied” N/A No source ER section is empty; the ER’s High benefit and High risk tiers are handled under items 12.5/13.5 rather than by empty-state phrasing.
4.2 Where the ER presents a bulleted item as “Label: content”, the QRS uses the ER’s bold label verbatim as the cell or row label. 🟢 Protocol labels “Studied doses”, “Time of day”, “Single versus split dosing” are the ER’s bold labels verbatim (ER l.353-359); interaction row labels reproduce the ER’s bold labels (ER l.294-312).
4.3 Labels are not paraphrased, abbreviated, or invented. 🟢 All 15 monitoring marker names and all three protocol labels are verbatim ER strings; no invented labels.
4.4 The QRS DOES NOT use emoji indicators (no 🟩, 🟥, 🟨, etc.). Color and emphasis are conveyed through CSS and bold labels. 🟢 No emoji characters anywhere in the file (verified over the full document); the ER’s ⚠️ Conflicted marker was correctly dropped.
4.5 The QRS is designed to render on one A4 page. Any section that has more content in the ER than fits the per-section budget is condensed by the LLM, not extended onto a second page. 🟢 Every section is condensed rather than extended: four benefit tiers reduced to three one-line entries, five risk tiers to three, contraindication and interaction bullets stripped of glosses and rationale.

5. Metadata

# Description Result Comments
5.1 The metadata is placed inside a single HTML comment that is the first element after “<!doctype html>” and before any other comment, head, or body content. 🟢 The metadata comment is the first element after <!doctype html> (l.2-14), before the template comment at l.16.
5.2 Inside that HTML comment the YAML block is delimited by a line “—” opening and a line “—” closing. Text before the opening “—” is permitted but is not parsed as YAML. 🟢 YAML opened at l.3 and closed at l.13; the descriptive text at l.2 precedes the opening marker.
5.3 The metadata is not visible in any rendered view of the QRS and is not surfaced by any other element on the sheet. 🟢 Enclosed in an HTML comment; no metadata value is echoed by any rendered element.
5.4 All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. 🟢 All values trimmed and unquoted except duration: “00:03”, which contains a colon and therefore requires quoting.
5.5 The filename of the source ER is stated as “er_filename: [er_filename]” 🟢 er_filename: atx_304_2026-0827-1322_Opus_ER.md (l.4).
5.6 Version of the QRS.md file used to create the document is stated as “qrs_prompt_version: [Version of QRS.md]” 🟢 qrs_prompt_version: 26.7.02 (l.5), matching the version badge of QRS.md.
5.7 Creation date and time of the document is stated as “qrs_creation_date: [YYYY-MMDD-HHMM]” (e.g., 2026-0501-1430) 🟢 qrs_creation_date: 2026-0827-1614 (l.6), correct YYYY-MMDD-HHMM format.
5.8 The nickname of the AI used to create the document is stated as “qrs_creator_ai_nickname: [qrs_creator_ai_nickname]” 🟢 qrs_creator_ai_nickname: Opus (l.7).
5.9 The nickname of the AI is just a single word model name without version, etc. (e.g., Opus, Sonnet, Grok, Gemini, ChatGPT) 🟢 “Opus” is a single word with no version or qualifier.
5.10 The full name of the AI used to create the document is stated as “qrs_creator_ai_fullname: [qrs_creator_ai_fullname]” 🟢 qrs_creator_ai_fullname: Opus 5 (l.8).
5.11 The full name of the AI consists of the [qrs_creator_ai_nickname] and the model version number and no additional qualifier (e.g., Opus 4.6, Sonnet 3.2, Grok 4.5, Gemini 3.1, ChatGPT 5.4) 🟢 “Opus 5” = nickname plus version number, no additional qualifier.
5.12 The filename of the document is stated as “qrs_filename: [filename of this document]” 🟢 qrs_filename: atx_304_2026-0827-1322_Opus_QRS.html (l.9), matching the file on disk.
5.13 All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. 🟢 Re-verified: no stray whitespace or unnecessary quoting in any frontmatter value.

6. Page Title & Header

# Description Result Comments
6.1 [page_title] is set to the [canonical_topic] of the ER frontmatter followed by “ - Quick Reference Sheet” (e.g., “Intervention - Quick Reference Sheet”). The [canonical_topic] is HTML-entity-encoded as needed (e.g., &amp; for &) 🟢 ATX-304 for Health & Longevity - Quick Reference Sheet (l.22) — canonical_topic plus the fixed suffix, with & entity-encoded.
6.2 [header_topic] is set to the [canonical_topic] of the ER frontmatter, with HTML entities encoded as needed (e.g., &amp; for &) 🟢 header_topic = “ATX-304 for Health & Longevity” (l.417), matching the ER canonical_topic with & encoded.
6.3 [header_subline_date] is set to [qrs_creation_date reformatted as MM/DD/YYYY] 🟢 header_subline_date = 08/27/2026 (l.421), the MM/DD/YYYY form of qrs_creation_date 2026-0827.
6.4 [header_subline_model] is set to [qrs_creator_ai_fullname] 🟢 header_subline_model = Opus 5 (l.425), matching qrs_creator_ai_fullname.
6.5 No additional header content appears: no badge, version stamp, AKA / alternate names line, source-AI attribution, audit date, or QRS variant marker. 🟢 Header carries only the template’s date, source-review and AI4L line; no badge, version stamp, AKA line (ER alternate names O304/O-304/ATX304 are not surfaced) or audit date.

7. At-A-Glance Section

# Description Result Comments
7.1 [at_a_glance] is dense, execution-oriented summary of the ER Conclusion section 🟢 Condenses the ER Conclusion (l.491-493): what the compound is, what the two studies moved, and the four limits that govern any decision.
7.2 [at_a_glance] is no longer than 60 words 🟢 59 words (counted programmatically), within the 60-word limit.
7.3 Every fact in [at_a_glance] is supported by a distinct passage in the ER. 🟢 Each clause maps to a distinct ER Conclusion passage — mechanism (l.491), the measured changes (l.491), no repeated result / four months / company funding / unverifiable supply (l.493).
7.4 It DOES NOT use acronyms or technical classifications that require specialist knowledge, uses plain-language terms instead 🟢 No acronyms or technical classifications; “the enzyme cells use to sense low fuel” replaces AMPK, “resting energy burn” replaces resting metabolic rate.
7.5 It DOES NOT cite specific trials (names, years, sample sizes, p-values) 🟢 “Two short studies” — no trial name (TELLUS is not used), no year, no sample size, no p-value.
7.6 It DOES NOT cite effect sizes, relative risks, or statistical results 🟢 No effect sizes, relative risks or statistics; “lowered”, “reduced”, “raised” carry direction only.

8. Contraindications

# Description Result Comments
8.1 The section is derived from the ER Key Interactions & Contraindications section 🟢 Derived from the ER’s Key Interactions & Contraindications section, populations list at l.314-325 plus the absolute-contraindication interaction at l.310.
8.2 [stop_items] represent the Contraindications from the ER 🟢 All 10 ER “Populations who should avoid ATX-304” bullets are present, plus the concomitant agent the ER itself grades “Severity: absolute contraindication” (ER l.310).
8.3 Individual [stop_items] are formatted as <li></li> 🟢 All 11 items are <li></li> elements inside the stop_items span.
8.4 Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. 🟢 ER rationale after the colon (e.g. “the compound is investigational and holds no marketing authorisation”) is stripped; no trailing dash clauses remain.
8.5 Parenthetical qualifiers from the ER bullet — time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). 🟢 Every qualifier preserved: “below 100 mmHg”, “Class III–IV”, “Child-Pugh Class B or C”, “eGFR below 45 mL/min/1.73 m²”, “within 90 days”, “without dose adjustment”. Only plain-language glosses were dropped.
8.6 When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. N/A The ER uses no ranking notation inside parentheses in this section.
8.7 The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no population, condition, or scenario for which the intervention should be avoided, deferred, or used only under specialist supervision. 🟢 The section is populated, and the ER does identify populations that should avoid the compound (l.314-325).
8.8 If the section is left empty, an HTML comment inside the [stop_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. N/A The section is not left empty.

9. Key Interactions

# Description Result Comments
9.1 The section is derived from the ER Key Interactions & Contraindications section 🟢 Derived from the ER’s Key Interactions & Contraindications bullets at l.294-312.
9.2 [caution_items] represent the Key Interactions from the ER, excluding any that are already listed as Contraindications 🟢 All 10 ER interaction bullets are represented except the mitochondrial-uncoupler bullet, which is correctly carried in Contraindications instead — 9 items, no duplication.
9.3 Individual [caution_items] are formatted as <li></li> 🟢 All 9 items are <li></li> elements inside the caution_items span.
9.4 Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. 🟢 Severity, consequence and mitigation text stripped from every bullet; the em-dash gloss on the GLP-1 entry (“— drugs mimicking a gut hormone…”) is removed.
9.5 Parenthetical qualifiers from the ER bullet — example drug lists, time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). 🟢 Example drug lists preserved verbatim for insulin/sulfonylureas, antihypertensives, GLP-1 agonists, diuretics, NSAIDs, AMPK-activating and blood-pressure-lowering supplements.
9.6 When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. N/A The ER uses no ranking notation inside parentheses in this section.
9.7 The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no interaction, additive effect, or exposure that changes how the intervention is used. 🟢 The section is populated, and the ER identifies ten interactions that change how the compound is used.
9.8 If the section is left empty, an HTML comment inside the [caution_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. N/A The section is not left empty.

10. Protocol

# Description Result Comments
10.1 The section is derived from the ER Protocol section 🟢 Derived from the ER Therapeutic Protocol section (l.349-377).
10.2 The three sets of [action] items cover the three most important actionable implementation aspects from the ER Protocol section 🟢 Studied doses, time of day and single-versus-split dosing are the three actionable implementation bullets; the remaining ER bullets are half-life, competing approaches and modifier discussion.
10.3 If less that three distinct actionable implementation aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. N/A The ER supplies three or more distinct actionable implementation aspects, so no set is unused.
10.4 All used [action_#label], [action#value], [action#_sub] items are filled with meaningful content derived from the ER Protocol section. 🟢 All nine action cells carry ER-derived content; action_1_sub reproduces both dosing arms including the 8-week open-label extension.

11. Time to Effect

# Description Result Comments
11.1 The three sets of [time] items cover the three most important time-to-effect aspects from the ER 🟢 Fasting glucose (days 21–28), blood pressure (day 28) and the 8-week fat/lipid/metabolic-rate readouts are the only time-anchored effects the ER reports.
11.2 The sets are picked and ordered by the magnitude of the related benefit 🟢 Ordered as the ER orders the corresponding Medium-tier benefits: glucose and insulin sensitivity first, blood pressure second, fat/lipid/metabolic-rate third.
11.3 If less that three distinct time-to-effect aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. N/A Three distinct time-to-effect aspects exist, so no set is unused.
11.4 All used [time_#label], [time#value], [time#_sub] items are filled with meaningful content derived from the ER. 🟢 All nine time cells carry ER-derived content; time_1_sub reproduces the ER’s 14-day steady-state caveat verbatim.
11.5 If the ER does not provide any information on time to effect, the section is removed completely from the Protocol Panel N/A The ER does provide time-to-effect information (l.412), so the section is correctly retained.

12. Benefits

# Description Result Comments
12.1 The section is derived from the ER Expected Benefits section 🟢 Derived from the ER Expected Benefits section (l.126-198).
12.2 Key variables are [benefits_high], [benefits_medium], [benefits_low], [benefits_speculative] 🟢 All four benefit spans present and correctly named.
12.3 Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. 🟢 Each tier is a semicolon-separated list of the ER’s benefit headings only — no magnitudes, p-values or mechanisms.
12.4 Parenthetical content — including effect sizes, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. 🟢 Parentheticals stripped, e.g. “Reduced Formation of Abdominal Aortic Aneurysm (a bulge in the body’s main artery)” → “reduced formation of abdominal aortic aneurysm”.
12.5 If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. 🟢 benefits_high is set to style=”display: none” and left empty, matching the ER’s “No benefit reaches High” (l.132); no empty-state phrasing was inserted.

13. Risks

# Description Result Comments
13.1 The section is derived from the ER Potential Risks & Side Effects section 🟢 Derived from the ER Potential Risks & Side Effects section (l.218-274).
13.2 Key variables are [risks_high], [risks_medium], [risks_low], [risks_speculative] 🟢 All four risk spans present and correctly named.
13.3 Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. 🟢 Each tier lists the ER’s risk headings only; the five speculative risks are reduced to their bare headings.
13.4 Parenthetical content — including frequencies, severity grades, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. 🟢 Parentheticals stripped, e.g. “Hypoglycemia (low blood sugar) in Combination with Glucose-Lowering Drugs” → “Hypoglycemia in combination with glucose-lowering drugs”.
13.5 If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. 🟢 risks_high is set to style=”display: none” and left empty, matching the ER’s “No risk reaches High” (l.224).

14. Monitoring

# Description Result Comments
14.1 The section is derived from the ER Monitoring section 🟢 Derived from the ER Monitoring Protocol & Defining Success section (l.438-458).
14.2 All measurable/quantifiable biomarkers from the Monitoring section are listed 🟢 All 15 ER biomarkers are listed in ER order, with target ranges and rationale reproduced verbatim.
14.3 [monitoring_cadence] is populated with the monitoring cadence/frequency derived from the ER Monitoring section. It is not left with placeholder text or empty. 🟢 monitoring_cadence condenses the ER’s baseline, daily/weekly, 4-/12-week, 3-6-month and 6-/12-month schedule plus the day-14 rule (ER l.440).

15. Qualitative Assessment

# Description Result Comments
15.1 The section is derived from the ER Monitoring section 🟢 Derived from the qualitative markers list in the ER Monitoring Protocol & Defining Success section (l.462-467).
15.2 All subjective/qualitative biomarkers from the Monitoring section are listed 🟢 All six ER qualitative markers are present and verbatim.

Issues 27/08/2026 16:21

Pass rate 100.00%. No issues found.