Audit: QRS - Aviptadil for Health & Longevity

Audit conducted on 12/09/2026 15:44 using AI4L / Opus 5

Iterations

Summary

Items Count
Total 93
Passed 83
Failed 0
N/A 10
Pass Rate 100.00%
  • Total = Passed + Failed + N/A
  • Pass Rate = Passed / (Passed + Failed) × 100
  • N/A items are excluded from the pass rate calculation

1. General Rules

# Description Result Comments
1.1 Every claim, magnitude, label, recommendation, and statement in the QRS is literally supported by content in the source ER. 🟢 Spot-checked every populated span against the ER: at-a-glance vs ER Conclusion (l.488-492), protocol cells vs ER Therapeutic Protocol (l.351-355), time cells vs Practical Considerations (l.412), benefit/risk tiers vs ER headings (l.140-194, l.218-274), gates vs l.296-325, monitoring vs l.442-455, qualitative vs l.459-464. No unsupported claim found.
1.2 Where the ER uses cautious phrasing (“not formally studied”, “None documented in human trials to date”, “theoretical concern”, “data are limited”), the QRS uses the same phrasing. 🟢 marker_6_target keeps the ER’s “No established treatment target” hedge (QRS l.721-724 vs ER l.449); speculative tiers carry no strengthened wording.
1.3 The QRS never strengthens an ER claim (e.g., “not formally studied” → “not required”) or softens one (e.g., “do not use during pregnancy” → “use with caution during pregnancy”). 🟢 Contraindication strength preserved (e.g. ER “Pregnant or breastfeeding women outside a supervised protocol” -> QRS l.577 “Pregnancy or breastfeeding outside a supervised protocol”); at-a-glance keeps “but not survival”.
1.4 The QRS does not relabel an ER fact under a different decision category. A “Benefit-Modifying Factor” from ER section is not surfaced as a “Caution”; a “Risk-Modifying Factor” is not surfaced as a “Side Effect”; etc. 🟢 stop_items map 1:1 to the ER’s “Populations who should avoid Aviptadil” list; caution_items map to the ER interaction bullets. No Benefit- or Risk-Modifying Factor is surfaced as a gate.
1.5 PubMed IDs, study citations, expert names, clinical trial identifiers (NCT*), and brand names appear in the QRS only if they appear in the source ER for the same fact. 🟢 No PMIDs, NCT ids, author names or brand names in the QRS. All named drugs and botanicals (sildenafil, tadalafil, alprostadil, papaverine, doxazosin, amlodipine, sacubitril/valsartan, Ginkgo biloba, Curcuma longa, etc.) appear in ER l.296-314.
1.6 The QRS does not introduce new attributions. 🟢 No attributions of any kind appear in the QRS.

2. Focus, Tone & Audience

# Description Result Comments
2.1 The QRS follows the tone of the ER, which is determined by the ER’s own language, phrasing, and framing. 🟢 Matches the ER’s measured, evidence-weighted register throughout.
2.2 The tone of the QRS is simultaneously expert, accessible, objective, and data-driven, but also empowering and encouraging 🟢 Expert and objective; protocol and monitoring panels are data-driven without hype.
2.3 The QRS reads as a trusted, knowledgeable guide rather than a prescriptive doctor 🟢 Content is stated as evidence and labelled regimen, not as instruction to a patient.
2.4 The QRS avoids language that implies medical or clinical advice 🟢 No advisory constructions; regimens and cadence are described, not prescribed.
2.5 The QRS “presents information” instead of “providing guidance”, “recommending”, or “advising” 🟢 No “recommend”, “advise”, “consider” or “should” in any rendered text (the only “Must” match is in a template CSS comment at l.130).
2.6 The QRS never addresses “the reader” directly — it presents evidence, not guidance 🟢 No second-person pronouns anywhere in the document.
2.7 The QRS is written in plain language, avoiding unnecessary medical jargon 🟢 Technical terms retained are the ER’s own biomarker and indication names, which are load-bearing; hs-CRP is expanded at l.705-707.
2.8 Information is presented in a concise and very compact manner 🟢 All entries are single-clause; benefit and risk tiers are reduced to semicolon-joined ER headings.
2.9 It DOES NOT address the reader directly 🟢 Confirmed: no direct address.
2.10 The target audience is health- and longevity-oriented adults who are risk-aware, proactive, and actively seeking to optimize health or apply the intervention under review. 🟢 Framed for a proactive, risk-aware reader: gates, thresholds and monitoring targets lead.
2.11 The target audience is willing to employ lifestyle and behavioral changes as well as follow protocols that may be inconvenient, costly, or require effort. 🟢 Presents an inconvenient regimen (continuous infusion, thrice-daily nebulisation, self-injection) without softening it.
2.12 The document is NOT written for the general population, who are unwilling to employ lifestyle and behavioral changes or follow protocols that may be inconvenient, costly, or require effort. 🟢 Not pitched at the general population; assumes willingness to engage with laboratory monitoring and route-specific protocols.
2.13 Framing, takeaways, and risk/benefit weighting throughout the document reflect this audience, including where an intervention’s signal for the average person differs from its signal for this audience. 🟢 At-a-glance (l.433-439) correctly weights the licensed local indication over the unresolved systemic one, which is the signal that matters for this audience.
2.14 The document’s own voice frames usage in longevity terms, not “anti-aging” (e.g., “anti-aging clinics”, “anti-aging community”, “anti-aging medicine”). Proper names that contain “anti-aging” (e.g., “American Academy of Anti-Aging Medicine”) are quoted verbatim. 🟢 No occurrence of “anti-aging” or “antiaging”.
2.15 The document’s own voice uses formal clinical and scientific terminology, not colloquial or consumer-grade language (e.g., “oral medication” not “pill(s)”; “oral” / “administered orally” not “taken by mouth” / “given by mouth”; “injection” not “shot”; “adverse event” not “bad reaction”). This holds on EVERY surface, including the QRS lede — the stricter plain-language bar (see 2.7) does not license lay phrasing for route of administration. Direct quotes from sources are exempt. 🟢 Route of administration is stated formally throughout (“Injected locally”, “Intravenous regimen”, “Nebulised”, “Intracavernosal”); no “pill”, “shot” or “by mouth”.

3. Template Integrity

# Description Result Comments
3.1 The following labels and headings on the QRS are fixed and not modified: Card and section headings: “Protocol”, “Time to effect”, “Benefits”, “Risk & Side Effects”, “Monitoring”, “Qualitative Assessment”; Gate headings: “Contraindications”, “Key Interactions”; Tier labels: “High”, “Medium”, “Low”, “Speculative”; Table column headers in Monitoring: “Marker”, “Target”, “Why” 🟢 “Protocol” (l.446), “Time to effect” (l.487), “Benefits” (l.529), “Risk & Side Effects” (l.617), “Monitoring” (l.645), “Qualitative Assessment” (l.817), “Contraindications” (l.561), “Key Interactions” (l.582), tier labels and “Marker / Target / Why” (l.649-651) are byte-identical to the template.
3.2 All “” from the [qrs_template] are present in the the QRS. 🟢 All 38 template spans present; marker_#* is expanded to marker_1..12 and qualitative_item# to qualitative_item_1..6.
3.3 Spans that are not addressed in a checklist item are left unchanged 🟢 Structural diff against [qrs_template] with text nodes stripped shows changes only inside data-qrs-var spans and the metadata block; CSS, website= spans, footer and disclaimer are unchanged.

4. Formatting

# Description Result Comments
4.1 When the source ER section is empty, the QRS uses the ER’s own empty-state phrasing verbatim. Typical phrasings are “None documented in human trials to date” and “Not formally studied” N/A No source ER section used by the QRS is empty, so no empty-state phrasing is required.
4.2 Where the ER presents a bulleted item as “Label: content”, the QRS uses the ER’s bold label verbatim as the cell or row label. 🟢 Protocol labels are the ER’s bold bullet labels verbatim: “Intravenous regimen for respiratory failure”, “Inhaled regimen”, “Intracavernosal regimen” (ER l.351-355).
4.3 Labels are not paraphrased, abbreviated, or invented. 🟢 All 12 monitoring marker names reproduce the ER biomarker-table column verbatim (ER l.444-455).
4.4 The QRS DOES NOT use emoji indicators (no 🟩, 🟥, 🟨, etc.). Color and emphasis are conveyed through CSS and bold labels. 🟢 No emoji characters anywhere in the file; the ER’s tier and “Conflicted” emoji are stripped.
4.5 The QRS is designed to render on one A4 page. Any section that has more content in the ER than fits the per-section budget is condensed by the LLM, not extended onto a second page. 🟢 Per-section condensation is applied as required: benefit and risk tiers are reduced to bare ER headings, gate items are stripped of consequence/mitigation clauses, marker_6_target is truncated, and qualitative items drop their trailing rationale. No section is carried over at ER length.

5. Metadata

# Description Result Comments
5.1 The metadata is placed inside a single HTML comment that is the first element after “<!doctype html>” and before any other comment, head, or body content. 🟢 The metadata comment opens at l.2, immediately after <!doctype html> at l.1, before <head>.
5.2 Inside that HTML comment the YAML block is delimited by a line “—” opening and a line “—” closing. Text before the opening “—” is permitted but is not parsed as YAML. 🟢 ”—” at l.3 opens and “—” at l.13 closes; the preamble text on l.2 is outside the block.
5.3 The metadata is not visible in any rendered view of the QRS and is not surfaced by any other element on the sheet. 🟢 Enclosed in an HTML comment and duplicated nowhere on the sheet.
5.4 All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. 🟢 All values trimmed; only duration is quoted, correctly, because “00:04” contains a colon.
5.5 The filename of the source ER is stated as “er_filename: [er_filename]” 🟢 l.4: er_filename: aviptadil_2026-0912-1219_Opus_ER.md
5.6 Version of the QRS.md file used to create the document is stated as “qrs_prompt_version: [Version of QRS.md]” 🟢 l.5: qrs_prompt_version: 26.9.11, matching the QRS.md version badge.
5.7 Creation date and time of the document is stated as “qrs_creation_date: [YYYY-MMDD-HHMM]” (e.g., 2026-0501-1430) 🟢 l.6: qrs_creation_date: 2026-0912-1536, correct YYYY-MMDD-HHMM form.
5.8 The nickname of the AI used to create the document is stated as “qrs_creator_ai_nickname: [qrs_creator_ai_nickname]” 🟢 l.7: qrs_creator_ai_nickname: Opus
5.9 The nickname of the AI is just a single word model name without version, etc. (e.g., Opus, Sonnet, Grok, Gemini, ChatGPT) 🟢 Single word, no version or qualifier.
5.10 The full name of the AI used to create the document is stated as “qrs_creator_ai_fullname: [qrs_creator_ai_fullname]” 🟢 l.8: qrs_creator_ai_fullname: Opus 5
5.11 The full name of the AI consists of the [qrs_creator_ai_nickname] and the model version number and no additional qualifier (e.g., Opus 4.6, Sonnet 3.2, Grok 4.5, Gemini 3.1, ChatGPT 5.4) 🟢 Nickname plus version number only; no additional qualifier.
5.12 The filename of the document is stated as “qrs_filename: [filename of this document]” 🟢 l.9: qrs_filename: aviptadil_2026-0912-1219_Opus_QRS.html, matching the file on disk.
5.13 All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. 🟢 Re-verified: no stray whitespace or unnecessary quoting in any of the nine keys.

6. Page Title & Header

# Description Result Comments
6.1 [page_title] is set to the [canonical_topic] of the ER frontmatter followed by “ - Quick Reference Sheet” (e.g., “Intervention - Quick Reference Sheet”). The [canonical_topic] is HTML-entity-encoded as needed (e.g., &amp; for &) 🟢 l.22: “Aviptadil for Health & Longevity - Quick Reference Sheet”, matching canonical_topic with the ampersand entity-encoded.
6.2 [header_topic] is set to the [canonical_topic] of the ER frontmatter, with HTML entities encoded as needed (e.g., &amp; for &) 🟢 l.417: “Aviptadil for Health & Longevity”.
6.3 [header_subline_date] is set to [qrs_creation_date reformatted as MM/DD/YYYY] 🟢 l.421: 09/12/2026, the MM/DD/YYYY form of qrs_creation_date 2026-0912-1536.
6.4 [header_subline_model] is set to [qrs_creator_ai_fullname] 🟢 l.425: “Opus 5”, matching qrs_creator_ai_fullname.
6.5 No additional header content appears: no badge, version stamp, AKA / alternate names line, source-AI attribution, audit date, or QRS variant marker. 🟢 Subline is the unmodified template line; no badge, AKA line, version stamp or variant marker added.

7. At-A-Glance Section

# Description Result Comments
7.1 [at_a_glance] is dense, execution-oriented summary of the ER Conclusion section 🟢 l.433-439 condenses ER Conclusion l.488-492: the two therapeutic worlds, the licensed local indication as strongest evidence, and the transient respiratory effect.
7.2 [at_a_glance] is no longer than 60 words 🟢 57 words, under the 60-word cap.
7.3 Every fact in [at_a_glance] is supported by a distinct passage in the ER. 🟢 Each of the three sentences traces to a distinct Conclusion passage (ER l.488, l.488-489, l.490).
7.4 It DOES NOT use acronyms or technical classifications that require specialist knowledge, uses plain-language terms instead 🟢 No acronyms; uses “synthetic copy of a natural signalling molecule”, “quietens immune cells”, “oxygen transfer” rather than VIP, VPAC, or PaO2/FiO2.
7.5 It DOES NOT cite specific trials (names, years, sample sizes, p-values) 🟢 No trial names, years, sample sizes or p-values.
7.6 It DOES NOT cite effect sizes, relative risks, or statistical results 🟢 No effect sizes, odds ratios or confidence intervals; “briefly, but not survival” is qualitative.

8. Contraindications

# Description Result Comments
8.1 The section is derived from the ER Key Interactions & Contraindications section 🟢 All eight items trace to the ER’s “Populations who should avoid Aviptadil” list under Key Interactions & Contraindications (ER l.316-325).
8.2 [stop_items] represent the Contraindications from the ER 🟢 All eight ER populations are represented, in ER order (QRS l.564-577).
8.3 Individual [stop_items] are formatted as <li></li> 🟢 Eight <li> elements inside the stop_items span.
8.4 Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. 🟢 Trailing rationale removed, e.g. ER “…outside a supervised protocol, since exposure data are limited to isolated case reports” -> QRS l.577 “Pregnancy or breastfeeding outside a supervised protocol”. Leading “People with / Men with / People taking” stripped.
8.5 Parenthetical qualifiers from the ER bullet — time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). 🟢 Route and threshold qualifiers preserved: “(intracavernosal route)” l.564 and l.566, “(under 90 days)” l.568, “below 25%” and “(systemic route)” l.572-573.
8.6 When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. N/A The ER uses no ranking notation inside parentheses in this section.
8.7 The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no population, condition, or scenario for which the intervention should be avoided, deferred, or used only under specialist supervision. 🟢 The section is populated, and the ER does identify populations to avoid the intervention, so the empty-only condition is respected.
8.8 If the section is left empty, an HTML comment inside the [stop_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. N/A The section is not left empty.

9. Key Interactions

# Description Result Comments
9.1 The section is derived from the ER Key Interactions & Contraindications section 🟢 All nine items trace to the ER interaction bullets at l.296-314.
9.2 [caution_items] represent the Key Interactions from the ER, excluding any that are already listed as Contraindications 🟢 Nine of the ER’s ten interaction bullets appear; anticoagulants is correctly omitted because it is already carried as a contraindication at QRS l.566.
9.3 Individual [caution_items] are formatted as <li></li> 🟢 Nine <li> elements inside the caution_items span.
9.4 Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. 🟢 Consequence and Mitigation clauses are stripped from every bullet; the em-dash gloss in the PDE5 parenthetical is removed (QRS l.586-587 vs ER l.298).
9.5 Parenthetical qualifiers from the ER bullet — example drug lists, time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). 🟢 Example drug lists preserved for every applicable item: (sildenafil, tadalafil), (alprostadil, papaverine), (glyceryl trinitrate, isosorbide mononitrate), (doxazosin, amlodipine, diuretics), (sacubitril/valsartan), (aspirin, ibuprofen, naproxen), (pseudoephedrine, phenylephrine), and the two supplement lists.
9.6 When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. N/A The ER uses no ranking notation inside parentheses in this section.
9.7 The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no interaction, additive effect, or exposure that changes how the intervention is used. 🟢 The section is populated, and the ER does identify interactions, so the empty-only condition is respected.
9.8 If the section is left empty, an HTML comment inside the [caution_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. N/A The section is not left empty.

10. Protocol

# Description Result Comments
10.1 The section is derived from the ER Protocol section 🟢 All three action sets derive from ER Therapeutic Protocol l.351-355.
10.2 The three sets of [action] items cover the three most important actionable implementation aspects from the ER Protocol section 🟢 The three route-specific regimens (intravenous, inhaled, intracavernosal) are the ER’s only dosing-actionable bullets; the remaining Protocol bullets are contextual.
10.3 If less that three distinct actionable implementation aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. N/A The ER supplies three distinct actionable regimens, so no set is unused.
10.4 All used [action_#label], [action#value], [action#_sub] items are filled with meaningful content derived from the ER Protocol section. 🟢 All nine action fields carry ER-derived content, e.g. l.453 “50 -> 100 -> 150 pmol/kg/hour” and l.457 “600, 1,200 then 1,800 pmol/kg per day” from ER l.351.

11. Time to Effect

# Description Result Comments
11.1 The three sets of [time] items cover the three most important time-to-effect aspects from the ER 🟢 Erection, breathlessness and oxygenation are the only three time-to-effect aspects the ER states (l.412).
11.2 The sets are picked and ordered by the magnitude of the related benefit 🟢 Order matches benefit magnitude: Erection (High tier, ER l.140-146), Breathlessness (Medium, ER l.148-154), Oxygenation (Low, ER l.156-162).
11.3 If less that three distinct time-to-effect aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. N/A The ER supplies three distinct time-to-effect aspects, so no set is unused.
11.4 All used [time_#label], [time#value], [time#_sub] items are filled with meaningful content derived from the ER. 🟢 All nine time fields carry ER-derived content (QRS l.493-522).
11.5 If the ER does not provide any information on time to effect, the section is removed completely from the Protocol Panel N/A The ER does provide time-to-effect information, so the row is retained.

12. Benefits

# Description Result Comments
12.1 The section is derived from the ER Expected Benefits section 🟢 All four tiers derive from ER Expected Benefits l.136-194.
12.2 Key variables are [benefits_high], [benefits_medium], [benefits_low], [benefits_speculative] 🟢 All four benefit spans are present and populated (QRS l.531-548).
12.3 Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. 🟢 Each tier is a semicolon-joined list of the ER’s own benefit headings with magnitudes, citations and the Conflicted marker removed.
12.4 Parenthetical content — including effect sizes, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. 🟢 No parenthetical content survives in any benefit item.
12.5 If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. N/A All four benefit tiers have at least one ER item, so no span needs hiding.

13. Risks

# Description Result Comments
13.1 The section is derived from the ER Potential Risks & Side Effects section 🟢 All four tiers derive from ER Potential Risks & Side Effects l.214-274.
13.2 Key variables are [risks_high], [risks_medium], [risks_low], [risks_speculative] 🟢 All four risk spans are present and populated (QRS l.619-639).
13.3 Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. 🟢 Each tier is a semicolon-joined list of the ER’s own risk headings; frequencies and mechanistic text are dropped.
13.4 Parenthetical content — including frequencies, severity grades, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. 🟢 No parenthetical frequencies or severity grades survive in any risk item.
13.5 If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. N/A All four risk tiers have at least one ER item, so no span needs hiding.

14. Monitoring

# Description Result Comments
14.1 The section is derived from the ER Monitoring section 🟢 The table derives from the ER Monitoring Protocol & Defining Success section (l.436-455).
14.2 All measurable/quantifiable biomarkers from the Monitoring section are listed 🟢 All 12 ER biomarker rows are reproduced, with targets and reasons verbatim (QRS l.655-801).
14.3 [monitoring_cadence] is populated with the monitoring cadence/frequency derived from the ER Monitoring section. It is not left with placeholder text or empty. 🟢 l.806-811 carries the full ER cadence sentence from l.440, including the 4-week and 6-week/3-month review points.

15. Qualitative Assessment

# Description Result Comments
15.1 The section is derived from the ER Monitoring section 🟢 The list derives from the ER’s qualitative markers block at l.457-464.
15.2 All subjective/qualitative biomarkers from the Monitoring section are listed 🟢 All six ER qualitative markers are present (QRS l.819-847), with trailing rationale trimmed on items 1 and 2.

Issues 12/09/2026 15:44

Pass rate 100.00%. No issues found.