Two slightly different tones, one per ear through headphones, create a pulsing beat the brain builds itself. Costs essentially nothing. Clearest finding: less anxiety and short-term pain around medical procedures, with less sedative and less painkiller needed afterwards. Sleep improves modestly in poor sleepers. Memory and attention gains are small and inconsistent. The main risk is headphone sound exposure. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Pure-tone audiometry, 0.25–8 kHz | ≤15 dB HL at every frequency; ear-to-ear gap ≤10 dB | Confirms the beat can be constructed and sets the noise-damage reference |
| Extended high-frequency audiometry, 9–16 kHz | Within 10 dB of age-matched norms | Earliest detectable sign of noise damage from headphones |
| Weekly headphone audio exposure | ≤80 dB(A) averaged over 40 hours per week | Direct measure of the only cumulative hazard |
| Pittsburgh Sleep Quality Index | ≤5 total score | Primary sleep endpoint used across the trials |
| State-Trait Anxiety Inventory, state form | ≤35 in adults | Primary anxiety endpoint used across the trials |
| Resting heart-rate variability, RMSSD | No established target; a sustained rise of roughly 10% from the individual's own baseline is meaningful | Objective autonomic readout of the relaxation claim |
| Sleep-onset latency | ≤20 minutes | Objective counterpart to the sleep questionnaire |
Cadence: Baseline before starting; questionnaires re-scored at 4 weeks and 12 weeks; hearing test repeated every 12–24 months, or sooner if tinnitus or muffled hearing appears.