A reactive plant defense chemical from cress and nasturtium. Its appetite for sulfur groups switches on the body's own detoxification genes and irritates surfaces it touches. Fewer repeat bladder and airway infections come from one licensed herbal product tested largely by its maker; slower spread of treated bladder cancer, from observation alone. Purified compound: never given to a person. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Urinalysis with microscopy (red blood cells, protein) | No blood, no protein | Sentinel test for the urothelial toxicity seen in rats |
| Urinary total isothiocyanates | No established target; change from own baseline | Confirms absorption and delivery to the bladder |
| TSH | 0.5–2.0 mIU/L | Detects the iodine-competition effect seen in animals |
| Free T4 | Middle to upper half of the laboratory range | Separates a genuine thyroid effect from an isolated TSH drift |
| Urinary iodine concentration | 100–199 µg/L | Iodine sufficiency is where the thyroid risk disappears |
| Creatinine and eGFR | eGFR at or above 90 mL/min/1.73 m² | Contraindicated below 30 mL/min/1.73 m² |
| ALT and AST | ALT <25 U/L men, <20 U/L women | Cleared by hepatic conjugation, so liver strain shows here first |
Cadence: Baseline, 4 weeks, 12 weeks, then every 6 to 12 months on repeated prophylaxis courses. Acute short courses need no interval testing.