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Bromantane for Health & Longevity

Created on 11/04/2026 – Quick Reference based on Evidence Review created using AI4L / Opus 5.5 – Audit

Bromantane, a drug that prompts the brain to make more of its own dopamine, has been prescribed in Russia for persistent exhaustion. Small studies in people with fatigue disorders, several from its developer, found less tiredness within days, often with calmer mood. Reported side effects at standard doses were uncommon and mild, chiefly overstimulation and trouble falling asleep. Safety beyond a month is unknown; nothing links it to longer life. (Full Review)

Protocol

Label regimen (conventional approach)
50–100 mg per dose, 100–200 mg daily
In two doses, with or without food, for 2–4 weeks
Time of day
Morning or early afternoon
The label excludes doses after 4 p.m.; peak blood levels 2–4 hours after a dose
Biohacker low-dose approach
30 mg in the morning
Taken intermittently rather than daily; personal practice, not trial-tested
Time to effect
Reduced Asthenia and Fatigue Symptoms
By day 3
Of a course, in patients with fatigue disorders
Mental Performance Under Fatigue
Within hours
After a single dose

Benefits

Contraindications
  • Pregnancy
  • Breastfeeding
  • Under 18 years
  • Prior hypersensitivity to bromantane or tablet components
  • Athletes subject to anti-doping testing
  • Bipolar disorder or psychotic disorders
  • History of stimulant use disorder
  • Severe liver impairment (Child-Pugh Class C)
    •
Key Interactions
  • Thiopental
  • Benzodiazepines (diazepam, alprazolam)
    •
Theoretical (inferred from mechanism)
  • MAO inhibitors (selegiline, phenelzine)
  • Prescription stimulants (amphetamine, methylphenidate)
  • Dopaminergic drugs (levodopa, bupropion)
  • Dopamine blockers (haloperidol, metoclopramide)
  • Drugs cleared by liver enzymes (warfarin, oral contraceptives)
  • Over-the-counter sleep aids (diphenhydramine)
  • Over-the-counter decongestants and caffeine (pseudoephedrine)
  • Dopamine-precursor and stimulant supplements (L-Tyrosine, yohimbine)
  • Adaptogenic supplements (Rhodiola rosea)
  • Alcohol
    •

Risk & Side Effects

  • High:
  • Medium:
  • Low: Overstimulation and difficulty falling asleep; allergic reactions; tolerance, dependence and withdrawal
    •
  • Speculative: Blood cell and liver changes at high doses; reproductive and developmental effects; neurological toxicity at high doses
    •

Monitoring

Marker Target Why
Blood pressure Below 130/80 mmHg Safety check: a rise stops or changes use
Resting heart rate 60–100 beats per minute Safety check: a sustained rise stops or changes use
MFI-20 fatigue score No established target; track change from the individual's own baseline Expected to change: fatigue
STAI anxiety score No established target; track change from the individual's own baseline Expected to change: anxiety
Complete blood count (neutrophils, hemoglobin) Neutrophils 1.5–8.0 × 10⁹/L; hemoglobin 12.0–15.5 g/dL in women, 13.5–17.5 g/dL in men Safety check: a fall stops use
ALT 7–56 U/L Safety check: a rise above 3 times normal stops use
Pregnancy test (hCG) Negative Safety check: a positive result stops use

Cadence: Baseline before a first course; home blood pressure and heart rate at 1 and 2 weeks into each course; fatigue and anxiety scores at 2 and 4 weeks; blood count and ALT at the end of any course longer than 4 weeks, then every 6–12 months for repeated courses; pregnancy test before each course in women who could become pregnant

Qualitative Assessment

  • Daytime energy and resistance to mental fatigue
  • Time to fall asleep and night waking
  • Calmness versus irritability or restlessness
  • Motivation and ability to sustain focused work
  • Exercise tolerance and recovery
  • Palpitations or headaches during a course
  • Mood and energy in the weeks after a course ends
Not medical advice. Educational distillation of a single evidence review. Confirm any decision with a qualified clinician, especially in the presence of prescription drugs or chronic conditions.