A stabilized form of a molecule the body makes naturally that supports cellular energy and gene regulation, both of which decline with age. Animal evidence is far stronger than human evidence, and its central longevity promise stays unproven. A low-cost, biologically plausible option; the main practical concerns are mild digestive upset and an added calcium load. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Serum calcium | 8.6–10.0 mg/dL | Detects hypercalcemia from the added calcium load |
| eGFR | >90 mL/min/1.73m² | Flags reduced calcium clearance and kidney-stone risk |
| hs-CRP | <1.0 mg/L | Tracks the proposed anti-inflammatory benefit |
| 25-Hydroxy Vitamin D | 40–60 ng/mL | High vitamin D raises calcium absorption, compounding the calcium load |
| Epigenetic age | At or below chronological age | The primary marker the intervention targets |
Cadence: Serum calcium and kidney function at ~3 months, then every 6–12 months; epigenetic clock and inflammatory markers every 6–12 months