A low-cost supplement that aims to help the body clear used hormones and unwanted substances more fully by slowing an enzyme that would otherwise let them return. Laboratory and animal work shows lower hormone levels and less tumor formation, but human proof is missing. Safety is gentle; the main caution is faster removal of some medicines, including birth control. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Estradiol (E2) | Premenopausal ~30–200 pg/mL; men ~10–40 pg/mL | Primary target hormone the compound aims to help clear |
| Estrone (E1) | ~30–100 pg/mL | Secondary estrogen affected by recirculation |
| SHBG | ~40–80 nmol/L (women); ~20–60 nmol/L (men) | Governs how much estrogen is free and active |
| LDL cholesterol | < 100 mg/dL | Tracks the possible lipid-lowering effect seen in animals |
| GGT | < 20–25 U/L | Liver-clearance and oxidative-stress marker |
| Urinary D-glucaric acid | No standardized optimal target | Validated marker of glucuronidation/detoxification activity |
Cadence: Estrogen markers at 8–12 weeks, then every 6–12 months if continued; lipid and liver markers every 6–12 months