Centrophenoxine is an older brain medicine, also sold as a supplement, used for memory and hoped to slow brain aging. Human evidence is thin: few small, decades-old studies with mixed results; life-span and age-pigment findings come only from animals. Side effects are mostly mild: restlessness, poor sleep, headache. The evidence is too small and dated to confirm memory or longevity benefits in healthy adults. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Blood pressure | <120/80 mmHg | Its choline-like component raised blood pressure |
| Resting heart rate | 50–70 beats/min | Detects stimulant or cholinergic effects |
| ALT | 10–25 U/L | Liver processes the compound |
| AST | 10–25 U/L | Liver safety |
| eGFR | >90 mL/min/1.73 m² | Kidneys clear one of its breakdown products |
| Fasting glucose | 75–90 mg/dL | One study reported lower fasting glucose |
| Homocysteine | 5–8 µmol/L | Reflects choline and methylation status |
| Cognitive test score | No established target; track change from own baseline | Objective check of benefit |
| Pregnancy test | Negative | Excludes pregnancy |
Cadence: Baseline before starting; blood pressure weekly for the first 4 weeks, then monthly; repeat labs and cognitive testing at 8–12 weeks, then every 6 months for as long as use continues