Audit: QRS - Clascoterone for Hair Regrowth

Audit conducted on 08/08/2026 11:21 using AI4L / Opus 5

Iterations

Summary

Items Count
Total 91
Passed 81
Failed 0
N/A 10
Pass Rate 100.00%
  • Total = Passed + Failed + N/A
  • Pass Rate = Passed / (Passed + Failed) × 100
  • N/A items are excluded from the pass rate calculation

1. General Rules

# Description Result Comments
1.1 Every claim, magnitude, label, recommendation, and statement in the QRS is literally supported by content in the source ER. 🟢 Spot-checked against ER: protocol regimen (ER 402, 412, 416, 424), time-to-effect (ER 457), benefit/risk headings (ER 184–319), contraindications (ER 362–374), interactions (ER 343–357), monitoring table (ER 489–497), qualitative markers (ER 503–508), at-a-glance (ER 532–536).
1.2 Where the ER uses cautious phrasing (“not formally studied”, “None documented in human trials to date”, “theoretical concern”, “data are limited”), the QRS uses the same phrasing. 🟢 “theoretical risk of feminizing effects on a male fetus” and “unknown consequences of multi-year androgen receptor blockade” carried over verbatim; “Post-marketing signals for…” retains the ER’s signal-not-causation framing.
1.3 The QRS never strengthens an ER claim (e.g., “not formally studied” → “not required”) or softens one (e.g., “do not use during pregnancy” → “use with caution during pregnancy”). 🟢 Population qualifiers (“in men with mild-to-moderate pattern hair loss”, “in younger women”) are retained rather than generalised; contraindications keep their thresholds.
1.4 The QRS does not relabel an ER fact under a different decision category. A “Benefit-Modifying Factor” from ER section is not surfaced as a “Caution”; a “Risk-Modifying Factor” is not surfaced as a “Side Effect”; etc. 🟢 Contraindications drawn only from ER “Populations Who Should Avoid This Intervention”; Key Interactions only from ER “Key Interactions & Contraindications” bullets; no Benefit- or Risk-Modifying Factor is surfaced as a gate.
1.5 PubMed IDs, study citations, expert names, clinical trial identifiers (NCT*), and brand names appear in the QRS only if they appear in the source ER for the same fact. 🟢 No PMIDs, NCT identifiers, expert names or brand names (Winlevi, Breezula) appear anywhere in the QRS.
1.6 The QRS does not introduce new attributions. 🟢 No sponsor, investigator or institution is named in the QRS.

2. Focus, Tone & Audience

# Description Result Comments
2.1 The QRS follows the tone of the ER, which is determined by the ER’s own language, phrasing, and framing. 🟢 Measured, evidence-first framing matches the ER, including the ER’s insistence that the pivotal dataset is unpublished.
2.2 The tone of the QRS is simultaneously expert, accessible, objective, and data-driven, but also empowering and encouraging 🟢 Monitoring targets, decision points and qualitative markers give the reader actionable levers without overstating the evidence.
2.3 The QRS reads as a trusted, knowledgeable guide rather than a prescriptive doctor 🟢 Content is stated descriptively (trial regimen, observed timings, measured ranges) rather than issued as personal instruction.
2.4 The QRS avoids language that implies medical or clinical advice 🟢 No “you should”, “consult”, “take” constructions; footer disclaimer is template text.
2.5 The QRS “presents information” instead of “providing guidance”, “recommending”, or “advising” 🟢 Protocol cells present the trial regimen; Monitoring presents ranges and cadence. No recommending verbs.
2.6 The QRS never addresses “the reader” directly — it presents evidence, not guidance 🟢 No second-person pronouns in any populated span.
2.7 The QRS is written in plain language, avoiding unnecessary medical jargon 🟢 Technical terms retained only where they are the biomarker or condition name; at-a-glance uses plain-language equivalents (“docking sites”, “male-type hormones”).
2.8 Information is presented in a concise and very compact manner 🟢 Every item is a short phrase or single clause; ER paragraphs are reduced to headline facts.
2.9 It DOES NOT address the reader directly 🟢 Confirmed across all 61 populated spans.
2.10 The target audience is health- and longevity-oriented adults who are risk-aware, proactive, and actively seeking to optimize health or apply the intervention under review. 🟢 Functional ranges, baseline-correction step and self-tracking markers assume a proactive, self-directed reader.
2.11 The target audience is willing to employ lifestyle and behavioral changes as well as follow protocols that may be inconvenient, costly, or require effort. 🟢 Twice-daily indefinite application, baseline lab panel and repeated potassium checks are presented without softening.
2.12 The document is NOT written for the general population, who are unwilling to employ lifestyle and behavioral changes or follow protocols that may be inconvenient, costly, or require effort. 🟢 No simplification toward casual use; the unapproved, compounded status and monitoring burden are carried through.
2.13 Framing, takeaways, and risk/benefit weighting throughout the document reflect this audience, including where an intervention’s signal for the average person differs from its signal for this audience. 🟢 At-a-glance foregrounds the unpublished-dataset limitation, which is the decision-relevant signal for this audience.
2.14 The document’s own voice frames usage in longevity terms, not “anti-aging” (e.g., “anti-aging clinics”, “anti-aging community”, “anti-aging medicine”). Proper names that contain “anti-aging” (e.g., “American Academy of Anti-Aging Medicine”) are quoted verbatim. 🟢 The string “anti-aging” does not occur in the QRS.
2.15 The document’s own voice uses formal clinical and scientific terminology, not colloquial or consumer-grade language (e.g., “oral medication” not “pill(s)”; “injection” not “shot”; “adverse event” not “bad reaction”). Direct quotes from sources are exempt. 🟢 “solution”, “application site”, “serum potassium”, “thyroid-stimulating hormone” used throughout; no consumer-grade substitutions.

3. Template Integrity

# Description Result Comments
3.1 The following labels and headings on the QRS are fixed and not modified:
• Card and section headings: “Protocol”, “Time to effect”, “Benefits”, “Risk & Side Effects”, “Monitoring”, “Qualitative Assessment”
• Gate headings: “Contraindications”, “Key Interactions”
• Tier labels: “High”, “Medium”, “Low”, “Speculative”
• Table column headers in Monitoring: “Marker”, “Target”, “Why”
🟢 All fixed headings present and unmodified (QRS lines 445, 491, 542, 575, 598, 627, 656, 660–662, 782); tier labels present in both Benefits and Risks.
3.2 All “” from the [qrs_template] are present in the the QRS. 🟢 61 named spans present and consistently numbered: page_title, header_, at_a_glance, action_1–3 (label/value/sub), time_1–3 (label/value/sub), benefits_, stop_items, caution_items, risks_*, marker_1–7 (name/target/why), monitoring_cadence, qualitative_item_1–6.
3.3 Spans that are not addressed in a checklist item are left unchanged 🟢 The website="evidence_review", website="audit" and website="full_review" placeholders and the footer disclaimer are untouched.

4. Formatting

# Description Result Comments
4.1 When the source ER section is empty, the QRS uses the ER’s own empty-state phrasing verbatim. Typical phrasings are “None documented in human trials to date” and “Not formally studied” N/A No source ER section relevant to the QRS is empty; every tier and every gate has content.
4.2 Where the ER presents a bulleted item as “Label: content”, the QRS uses the ER’s bold label verbatim as the cell or row label. 🟢 Monitoring row labels reproduce the ER biomarker names verbatim; gate items reproduce the ER bold labels (e.g., “Potassium supplements and potassium-based salt substitutes”, “Antiandrogenic supplements”, “Licorice root”).
4.3 Labels are not paraphrased, abbreviated, or invented. 🟢 No invented biomarker or gate label; acronym expansions from the ER table (“HPA”, “eGFR”, “TSH”) are dropped rather than substituted.
4.4 The QRS DOES NOT use emoji indicators (no 🟩, 🟥, 🟨, etc.). Color and emphasis are conveyed through CSS and bold labels. 🟢 No emoji characters in the file; the ER’s 🟩/🟥/🟨 and ⚠️ markers are not carried over.
4.5 The QRS is designed to render on one A4 page. Any section that has more content in the ER than fits the per-section budget is condensed by the LLM, not extended onto a second page. 🟢 Every section is condensed to its per-section budget: ER paragraphs become single clauses, benefit/risk tiers are collapsed to one line each, and the monitoring “Why” column is reduced to the ER’s short rationale.

5. Metadata

# Description Result Comments
5.1 The metadata is placed inside a single HTML comment that is the first element after “<!doctype html>” and before any other comment, head, or body content. 🟢 Comment opens on line 2, immediately after <!doctype html> on line 1, and closes on line 14 before the template comment.
5.2 Inside that HTML comment the YAML block is delimited by a line “—” opening and a line “—” closing. Text before the opening “—” is permitted but is not parsed as YAML. 🟢 Opening --- on line 3, closing --- on line 13; the descriptive text on line 2 precedes the opening delimiter.
5.3 The metadata is not visible in any rendered view of the QRS and is not surfaced by any other element on the sheet. 🟢 Enclosed in an HTML comment; no metadata value is echoed into the body except the template-mandated creation date and model name.
5.4 All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. 🟢 Only duration: "00:03" is quoted, correctly, because the value contains a colon.
5.5 The filename of the source ER is stated as “er_filename: [er_filename]” 🟢 Line 4: er_filename: clascoterone_hair_2026-0808-0711_Opus_ER.md, matching the ER’s own filename frontmatter.
5.6 Version of the QRS.md file used to create the document is stated as “qrs_prompt_version: [Version of QRS.md]” 🟢 Line 5: qrs_prompt_version: 26.7.02, matching the QRS.md version badge.
5.7 Creation date and time of the document is stated as “qrs_creation_date: [YYYY-MMDD-HHMM]” (e.g., 2026-0501-1430) 🟢 Line 6: qrs_creation_date: 2026-0808-1109, correct format.
5.8 The nickname of the AI used to create the document is stated as “qrs_creator_ai_nickname: [qrs_creator_ai_nickname]” 🟢 Line 7: qrs_creator_ai_nickname: Opus.
5.9 The nickname of the AI is just a single word model name without version, etc. (e.g., Opus, Sonnet, Grok, Gemini, ChatGPT) 🟢 “Opus” — single word, no version or qualifier.
5.10 The full name of the AI used to create the document is stated as “qrs_creator_ai_fullname: [qrs_creator_ai_fullname]” 🟢 Line 8: qrs_creator_ai_fullname: Opus 5.
5.11 The full name of the AI consists of the [qrs_creator_ai_nickname] and the model version number and no additional qualifier (e.g., Opus 4.6, Sonnet 3.2, Grok 4.5, Gemini 3.1, ChatGPT 5.4) 🟢 “Opus 5” — nickname plus version only, no context-window or tier qualifier.
5.12 The filename of the document is stated as “qrs_filename: [filename of this document]” 🟢 Line 9: qrs_filename: clascoterone_hair_2026-0808-0711_Opus_QRS.html, matching the file on disk.
5.13 All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. 🟢 All nine keys carry trimmed, unquoted values except the colon-bearing duration.

6. Page Title & Header

# Description Result Comments
6.1 [page_title] is set to the [canonical_topic] of the ER frontmatter followed by “ - Quick Reference Sheet” (e.g., “Intervention - Quick Reference Sheet”). The [canonical_topic] is HTML-entity-encoded as needed (e.g., &amp; for &) 🟢 Line 22: “Clascoterone for Hair Regrowth - Quick Reference Sheet”; ER canonical_topic is “Clascoterone for Hair Regrowth”; no entity encoding required.
6.2 [header_topic] is set to the [canonical_topic] of the ER frontmatter, with HTML entities encoded as needed (e.g., &amp; for &) 🟢 Line 417: “Clascoterone for Hair Regrowth”.
6.3 [header_subline_date] is set to [qrs_creation_date reformatted as MM/DD/YYYY] 🟢 Line 421: “08/08/2026” from qrs_creation_date: 2026-0808-1109.
6.4 [header_subline_model] is set to [qrs_creator_ai_fullname] 🟢 Line 425: “Opus 5”, matching qrs_creator_ai_fullname.
6.5 No additional header content appears: no badge, version stamp, AKA / alternate names line, source-AI attribution, audit date, or QRS variant marker. 🟢 Header carries only the title and the template subline; the ER’s “Also known as” line (Cortexolone 17α-propionate, CB-03-01, Breezula, Winlevi) is not reproduced.

7. At-A-Glance Section

# Description Result Comments
7.1 [at_a_glance] is dense, execution-oriented summary of the ER Conclusion section 🟢 Compresses the ER Conclusion (lines 532–536) into mechanism, what the scalp trials showed, the publication gap, and regulatory status.
7.2 [at_a_glance] is no longer than 60 words 🟢 56 words.
7.3 Every fact in [at_a_glance] is supported by a distinct passage in the ER. 🟢 Mechanism and inactivation → ER 532; gains built over a year and faded on stopping → ER 534; never published in full → ER 534; no regulator approval → ER 400 and 446.
7.4 It DOES NOT use acronyms or technical classifications that require specialist knowledge, uses plain-language terms instead 🟢 Uses “skin-applied hormone blocker”, “docking sites”, “male-type hormones”, “inactive form” instead of topical antiandrogen, androgen receptor, dihydrotestosterone, cortexolone.
7.5 It DOES NOT cite specific trials (names, years, sample sizes, p-values) 🟢 “Late-stage trials in men” only; SCALP 1/SCALP 2, 1,465 participants and p-values are all omitted.
7.6 It DOES NOT cite effect sizes, relative risks, or statistical results 🟢 No percentages, risk ratios or confidence intervals; the ER’s 539%/168%/239% figures are not carried over.

8. Contraindications

# Description Result Comments
8.1 The section is derived from the ER Key Interactions & Contraindications section 🟢 All seven items map to the “Populations Who Should Avoid This Intervention” subsection (ER lines 362–374).
8.2 [stop_items] represent the Contraindications from the ER 🟢 All seven ER contraindications are present, none added: pregnancy/breastfeeding, childbearing potential without contraception, adrenal insufficiency/systemic corticosteroids, CKD 3b or K⁺ >5.0, active scalp disease, non-androgenetic hair loss, under-18s.
8.3 Individual [stop_items] are formatted as <li></li> 🟢 Seven discrete <li> elements inside the stop_items span (QRS lines 578–593).
8.4 Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. 🟢 The ER’s post-em-dash explanations (e.g., “Any condition already compromising the cortisol axis — Addison’s disease…”, “…delays correct diagnosis…”) are all stripped; no dash-led clause survives.
8.5 Parenthetical qualifiers from the ER bullet — time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). 🟢 “stage 3b or worse”, “below 45 mL/min/1.73 m²”, “above 5.0 mEq/L”, “under 18” retained; disease examples kept in parentheses while the ER’s explanatory glosses are dropped.
8.6 When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. N/A The ER uses no ranking notation inside parentheses in its contraindication bullets.
8.7 If no [stop_items] are present the section is left empty N/A Seven contraindications are present.

9. Key Interactions

# Description Result Comments
9.1 The section is derived from the ER Key Interactions & Contraindications section 🟢 All nine items map to ER lines 343–357.
9.2 [caution_items] represent the Key Interactions from the ER, excluding any that are already listed as Contraindications 🟢 The ER’s “Systemic corticosteroids” bullet is correctly omitted because “current systemic corticosteroid therapy” is already a contraindication; the remaining seven ER bullets are represented (the composite “Over-the-counter medications” and “Other hair-loss interventions” bullets are split into their distinct agents).
9.3 Individual [caution_items] are formatted as <li></li> 🟢 Nine discrete <li> elements inside the caution_items span (QRS lines 601–617).
9.4 Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. 🟢 The ER’s “— caution, monitor” tags and all mechanism/mitigation prose are stripped; no item carries a trailing clause.
9.5 Parenthetical qualifiers from the ER bullet — example drug lists, time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). 🟢 Drug-class examples (ACE inhibitors, ARBs, potassium-sparing diuretics, direct renin inhibitors), NSAID examples, the antiandrogenic-supplement list, and the “within 24 hours of application” microneedling window are all retained.
9.6 When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. N/A The ER uses no ranking notation inside parentheses in its interaction bullets.
9.7 If no [caution_items] are present the section is left empty N/A Nine key interactions are present.

10. Protocol

# Description Result Comments
10.1 The section is derived from the ER Protocol section 🟢 Dose and technique from ER 402 and 461; frequency and split dosing from ER 402, 412 and 416; baseline biomarkers from ER 424.
10.2 The three sets of [action] items cover the three most important actionable implementation aspects from the ER Protocol section 🟢 Dose (1.5 mL of 5% solution), Frequency (twice daily, continuously) and Baseline biomarkers are the three implementation decisions the ER Protocol section turns on.
10.3 If less that three distinct actionable implementation aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. N/A The ER supplies well over three actionable aspects; all three sets are populated.
10.4 All used [action_#label], [action#value], [action#_sub] items are filled with meaningful content derived from the ER Protocol section. 🟢 All nine action spans carry substantive, ER-derived content; none is a placeholder.

11. Time to Effect

# Description Result Comments
11.1 The three sets of [time] items cover the three most important time-to-effect aspects from the ER 🟢 6 months (co-primary endpoints / earliest decision point), 12 months (continued accrual / fairer assessment) and 3 months (first measurable change) — the three horizons the ER names at line 457.
11.2 The sets are picked and ordered by the magnitude of the related benefit 🟢 Ordered by the ER’s own benefit ranking: scalp hair count first, continued accrual second, first measurable change last as the earliest but least conclusive signal.
11.3 If less that three distinct time-to-effect aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. N/A The ER supplies three distinct time-to-effect horizons; all three sets are populated.
11.4 All used [time_#label], [time#value], [time#_sub] items are filled with meaningful content derived from the ER. 🟢 All nine time spans carry ER-derived labels, values and sub-lines.
11.5 If the ER does not provide any information on time to effect, the section is removed completely from the Protocol Panel N/A The ER provides explicit time-to-effect data (line 457), so the section is retained.

12. Benefits

# Description Result Comments
12.1 The section is derived from the ER Expected Benefits section 🟢 All nine benefit statements correspond one-to-one with the ER’s Expected Benefits sub-headings (ER lines 184–241).
12.2 Key variables are [benefits_high], [benefits_medium], [benefits_low], [benefits_speculative] 🟢 All four spans present and populated at the correct tiers (QRS lines 544–568).
12.3 Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. 🟢 Each item is the ER sub-heading reduced to its key fact; the ER’s Magnitude lines (risk ratio 2.87, 539%/168%, 239%, 24.5%) are all dropped.
12.4 Parenthetical content — including effect sizes, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. 🟢 No parentheses appear in any benefits item.
12.5 If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. N/A All four ER benefit tiers contain items, so no span needs hiding.

13. Risks

# Description Result Comments
13.1 The section is derived from the ER Potential Risks & Side Effects section 🟢 All eight risk statements correspond one-to-one with the ER’s Potential Risks & Side Effects sub-headings (ER lines 270–319).
13.2 Key variables are [risks_high], [risks_medium], [risks_low], [risks_speculative] 🟢 All four spans present and populated at the correct tiers (QRS lines 629–650).
13.3 Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. 🟢 The ER’s Magnitude lines (7–12% erythema/pruritus, 3 of 42 subjects, 5% vs 4% potassium shifts, reporting odds ratios 1.83 and 1.88) are all dropped.
13.4 Parenthetical content — including frequencies, severity grades, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. 🟢 No parentheses appear in any risks item.
13.5 If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. N/A All four ER risk tiers contain items, so no span needs hiding.

14. Monitoring

# Description Result Comments
14.1 The section is derived from the ER Monitoring section 🟢 Markers, targets and rationales reproduce the ER Monitoring Protocol & Defining Success table (ER lines 487–495).
14.2 All measurable/quantifiable biomarkers from the Monitoring section are listed 🟢 All seven ER biomarkers present with matching targets: serum potassium 4.0–4.5 mEq/L, morning cortisol 12–18 µg/dL, ferritin 70–100 ng/mL, TSH 0.5–2.0 mIU/L, 25-hydroxyvitamin D 40–60 ng/mL, comprehensive metabolic panel with eGFR above 60, total testosterone 500–900 ng/dL.
14.3 [monitoring_cadence] is populated with the monitoring cadence/frequency derived from the ER Monitoring section. It is not left with placeholder text or empty. 🟢 QRS lines 770–776 reproduce the ER’s cadence at line 497: 4 weeks, 3 months, 6 months, then every 6–12 months, plus a check after starting a potassium-raising medication.

15. Qualitative Assessment

# Description Result Comments
15.1 The section is derived from the ER Monitoring section 🟢 All six items map to the ER’s “Qualitative markers to track alongside the numbers” list (ER lines 503–508).
15.2 All subjective/qualitative biomarkers from the Monitoring section are listed 🟢 All six present: daily shedding volume, scalp comfort, hair texture and styling behaviour, density at the part line and temples, energy/alertness/postural symptoms, confidence and appearance-related mood.

Issues 08/08/2026 11:21

Pass rate 100.00%. No issues found.

Issues 08/08/2026 11:12

  1. 9.2 — Corticosteroids duplicated across gates: “Systemic corticosteroids (oral, injected, high-potency inhaled)” appears as a Key Interaction at QRS line 605 even though “current systemic corticosteroid therapy” is already a Contraindication at line 580, so the same agent class occupies both the stop gate and the caution gate.

Fixes 08/08/2026 11:12

  1. 9.2 — Corticosteroids duplicated across gates: Removed the “Systemic corticosteroids (oral, injected, high-potency inhaled)” item from caution_items, since “current systemic corticosteroid therapy” is already carried in stop_items as a contraindication.