Colostrum is the antibody- and growth-factor-rich first milk; the adult supplement is cow-derived, taken to support the gut lining and immune defenses. The most consistent evidence, mainly in active adults, shows fewer upper-airway infection days during heavy training and improved leaky-gut markers. A low-risk option with modest gut and immune support; broader longevity promises stay unproven. (Full Review)
| Marker | Target | Why |
|---|---|---|
| hs-CRP (high-sensitivity C-reactive protein) | < 1.0 mg/L | Tracks systemic low-grade inflammation that colostrum is proposed to lower via gut-barrier support |
| Serum/salivary IgA (immunoglobulin A, a mucosal antibody) | Mid-to-upper of lab reference range | Reflects mucosal immune status, a plausible target of colostrum |
| Intestinal permeability (lactulose/mannitol or lactulose/rhamnose urinary ratio) | Below lab cutoff for "leaky gut" | The most direct marker of the gut-barrier benefit seen in trials |
| Serum ferritin / iron studies | Ferritin ~50–150 ng/mL | Lactoferrin binds iron, so iron status is worth watching if dosing alongside iron supplements |
Cadence: Baseline panel, an optional recheck at about 8–12 weeks, then every 6–12 months if continued long-term.