Audit: QRS - Cruciferous Vegetables for Health & Longevity
Audit conducted on 03/09/2026 04:08 using AI4L / Opus 5
Summary
| Items | Count |
|---|---|
| Total | 93 |
| Passed | 83 |
| Failed | 0 |
| N/A | 10 |
| Pass Rate | 100.00% |
- Total = Passed + Failed + N/A
- Pass Rate = Passed / (Passed + Failed) × 100
- N/A items are excluded from the pass rate calculation
1. General Rules
| # | Description | Result | Comments |
|---|---|---|---|
| 1.1 | Every claim, magnitude, label, recommendation, and statement in the QRS is literally supported by content in the source ER. | 🟢 | Spot-checked every populated span: protocol values (3–5 servings weekly, 300 g/day, 30–60 g/day 3-day sprouts, 20–60 mg sulforaphane potential) map to ER Therapeutic Protocol lines 357–361; all 10 monitoring rows and targets map to the ER biomarker table lines 452–461; time-to-effect values map to ER line 420. |
| 1.2 | Where the ER uses cautious phrasing (“not formally studied”, “None documented in human trials to date”, “theoretical concern”, “data are limited”), the QRS uses the same phrasing. | 🟢 | The one place the ER declines to set a value — urinary isothiocyanate excretion, “No established target exists” (ER line 461) — is carried as “None established; change from own baseline” (QRS line 753). No ER hedge is dropped or replaced by a firmer formulation. |
| 1.3 | The QRS never strengthens an ER claim (e.g., “not formally studied” → “not required”) or softens one (e.g., “do not use during pregnancy” → “use with caution during pregnancy”). | 🟢 | Radioactive iodine remains an absolute-gate item under Contraindications (QRS line 570), matching ER line 323; raw sprouts remain a hard avoid for pregnancy/over-65/under-5/immunocompromised (QRS line 571 vs ER line 333). CYP1A2 stays a Medium risk, thyroid and anticoagulation stay Low, matching ER tiers. |
| 1.4 | The QRS does not relabel an ER fact under a different decision category. A “Benefit-Modifying Factor” from ER section is not surfaced as a “Caution”; a “Risk-Modifying Factor” is not surfaced as a “Side Effect”; etc. | 🟢 | Gate items are drawn only from ER Key Interactions & Contraindications (lines 313–335); Benefits from Expected Benefits; Risks from Potential Risks & Side Effects; markers and qualitative items from Monitoring Protocol & Defining Success. No modifying factor is promoted into a gate. |
| 1.5 | PubMed IDs, study citations, expert names, clinical trial identifiers (NCT*), and brand names appear in the QRS only if they appear in the source ER for the same fact. | 🟢 | The QRS carries none: no PMIDs, no NCT identifiers, no Talalay/Fahey/Mithen attribution, no Avmacol or Beneforté brand names, although all appear in the ER. |
| 1.6 | The QRS does not introduce new attributions. | 🟢 | No named source, institution, author or organisation appears anywhere in the QRS body. |
2. Focus, Tone & Audience
| # | Description | Result | Comments |
|---|---|---|---|
| 2.1 | The QRS follows the tone of the ER, which is determined by the ER’s own language, phrasing, and framing. | 🟢 | Measured and deflationary in the same way as the ER conclusion — “Lifespan extension shown only in animals” (QRS line 438) mirrors ER line 493. |
| 2.2 | The tone of the QRS is simultaneously expert, accessible, objective, and data-driven, but also empowering and encouraging | 🟢 | Concrete actionable doses in the Protocol panel and concrete monitoring targets give the reader something to act on, while tiered Benefits/Risks keep the framing objective. |
| 2.3 | The QRS reads as a trusted, knowledgeable guide rather than a prescriptive doctor | 🟢 | Protocol cells describe the approaches used in trials (“Trial dosing 300 g/day…”, QRS line 457) rather than instructing. |
| 2.4 | The QRS avoids language that implies medical or clinical advice | 🟢 | No imperatives to the reader; monitoring targets and cadence are stated as tracked ranges and intervals carried verbatim from ER lines 446–461. |
| 2.5 | The QRS “presents information” instead of “providing guidance”, “recommending”, or “advising” | 🟢 | No instance of “recommend”, “advise”, “should”, or “you should” in the QRS body. |
| 2.6 | The QRS never addresses “the reader” directly — it presents evidence, not guidance | 🟢 | Verified: no second-person pronoun (“you”, “your”, “yours”) appears anywhere in the file. |
| 2.7 | The QRS is written in plain language, avoiding unnecessary medical jargon | 🟢 | Retained technical terms (CYP1A2, glucoraphanin, myrosinase, Brassicaceae) have no plain-language equivalent and are all carried from the ER; the acronyms HbA1c, ALT and INR are each expanded at their marker row before reuse in the cadence line. |
| 2.8 | Information is presented in a concise and very compact manner | 🟢 | Every gate item, benefit and risk is a bare noun phrase; monitoring “Why” cells run 3–6 words. |
| 2.9 | It DOES NOT address the reader directly | 🟢 | Confirmed by the same second-person scan as 2.6; also no vocative or imperative constructions. |
| 2.10 | The target audience is health- and longevity-oriented adults who are risk-aware, proactive, and actively seeking to optimize health or apply the intervention under review. | 🟢 | The sheet assumes a reader who will run a 10-marker panel and titrate a 300 g/day intake — a proactive optimiser, not a casual reader. |
| 2.11 | The target audience is willing to employ lifestyle and behavioral changes as well as follow protocols that may be inconvenient, costly, or require effort. | 🟢 | Home sprouting with twice-daily rinsing (QRS line 470) and a quarterly-to-annual biomarker cadence (QRS lines 765–767) both presuppose effort. |
| 2.12 | The document is NOT written for the general population, who are unwilling to employ lifestyle and behavioral changes or follow protocols that may be inconvenient, costly, or require effort. | 🟢 | Functional-range targets (HbA1c 4.8–5.4%, ALT below 25/20 U/L) sit well below conventional cut-offs and are meaningful only to an optimising audience. |
| 2.13 | Framing, takeaways, and risk/benefit weighting throughout the document reflect this audience, including where an intervention’s signal for the average person differs from its signal for this audience. | 🟢 | At-a-glance states plainly that lifespan extension is animal-only and that the human wins are modest, which is the honest signal for a longevity-oriented reader; the CYP1A2 and raw-sprout hazards are given gate-level prominence. |
| 2.14 | The document’s own voice frames usage in longevity terms, not “anti-aging” (e.g., “anti-aging clinics”, “anti-aging community”, “anti-aging medicine”). Proper names that contain “anti-aging” (e.g., “American Academy of Anti-Aging Medicine”) are quoted verbatim. | 🟢 | “anti-aging” does not occur; the title and header use “Health & Longevity”. |
| 2.15 | The document’s own voice uses formal clinical and scientific terminology, not colloquial or consumer-grade language (e.g., “oral medication” not “pill(s)”; “injection” not “shot”; “adverse event” not “bad reaction”). Direct quotes from sources are exempt. | 🟢 | Body sections use “gastrointestinal intolerance”, “destabilised anticoagulation”, “alanine aminotransferase”. The plainer register in At-A-Glance (“medicines wearing off faster”) is required there by item 7.4 and mirrors the ER conclusion’s own wording. |
3. Template Integrity
| # | Description | Result | Comments |
|---|---|---|---|
| 3.1 | The following labels and headings on the QRS are fixed and not modified: Card and section headings: “Protocol”, “Time to effect”, “Benefits”, “Risk & Side Effects”, “Monitoring”, “Qualitative Assessment”; Gate headings: “Contraindications”, “Key Interactions”; Tier labels: “High”, “Medium”, “Low”, “Speculative”; Table column headers in Monitoring: “Marker”, “Target”, “Why” | 🟢 | All present and byte-identical to the template: lines 446, 489, 537, 602, 630, 774 (card/section), 567 and 580 (gates), 540/544/550/556 and 606/611/615/621 (tiers), 634–636 (table headers). |
| 3.2 | All “…” from the [qrs_template] are present in the the QRS. | 🟢 | Extracted both var sets and compared: every one of the 38 template names is present, with the indexed placeholders correctly expanded (marker_#* → marker_1..10*, qualitative_item_# → qualitative_item_1..5). No template span is missing and no unknown span was invented. |
| 3.3 | Spans that are not addressed in a checklist item are left unchanged | 🟢 | A full line diff of the QRS against [qrs_template] returns only the frontmatter fill-in, the three appended frontmatter keys, and the variable substitutions themselves — no CSS, no structural markup, no comment and no website= span was altered. |
4. Formatting
| # | Description | Result | Comments |
|---|---|---|---|
| 4.1 | When the source ER section is empty, the QRS uses the ER’s own empty-state phrasing verbatim. Typical phrasings are “None documented in human trials to date” and “Not formally studied” | N/A | No ER section feeding the QRS is empty: Expected Benefits, Potential Risks & Side Effects, Key Interactions & Contraindications, Therapeutic Protocol and Monitoring Protocol & Defining Success are all populated, and all four evidence tiers carry items in both Benefits and Risks. |
| 4.2 | Where the ER presents a bulleted item as “Label: content”, the QRS uses the ER’s bold label verbatim as the cell or row label. | 🟢 | The three protocol labels are verbatim ER bold labels — “Whole-food baseline”, “Broccoli sprout protocol”, “Standardised extract protocol” (QRS lines 450, 463, 476 vs ER lines 357, 359, 361). Monitoring row labels reproduce the ER biomarker column verbatim. |
| 4.3 | Labels are not paraphrased, abbreviated, or invented. | 🟢 | No invented label; all ten marker names match the ER table cell text character-for-character, including “Glycated haemoglobin (HbA1c)” and “International normalised ratio (INR)”. |
| 4.4 | The QRS DOES NOT use emoji indicators (no 🟩, 🟥, 🟨, etc.). Color and emphasis are conveyed through CSS and bold labels. | 🟢 | Zero emoji characters in the file; the ER’s 🟩/🟥/🟨 tier markers and ⚠️ Conflicted flags were correctly dropped, with tiering carried by the bold “High:”/”Medium:”/”Low:”/”Speculative:” labels and the card CSS. |
| 4.5 | The QRS is designed to render on one A4 page. Any section that has more content in the ER than fits the per-section budget is condensed by the LLM, not extended onto a second page. | 🟢 | Condensation is applied throughout rather than content being spilled: benefit and risk headings are reduced to bare noun phrases, gate parentheticals are trimmed to 2–3 named examples, monitoring “Why” cells to 3–6 words, and the four-paragraph ER monitoring narrative to a four-sentence cadence line. No section was appended beyond the template’s single-sheet structure. |
5. Metadata
| # | Description | Result | Comments |
|---|---|---|---|
| 5.1 | The metadata is placed inside a single HTML comment that is the first element after “<!doctype html>” and before any other comment, head, or body content. | 🟢 | The comment opens at line 2, immediately after <!doctype html> on line 1, and closes at line 14 before the template comment on line 16. |
| 5.2 | Inside that HTML comment the YAML block is delimited by a line “—” opening and a line “—” closing. Text before the opening “—” is permitted but is not parsed as YAML. | 🟢 | Opening --- at line 3, closing --- at line 13; the preceding descriptive line “QRS — Metadata (invisible, parsed by audit tooling)” sits before the opener as permitted. |
| 5.3 | The metadata is not visible in any rendered view of the QRS and is not surfaced by any other element on the sheet. | 🟢 | It is inside an HTML comment and therefore not rendered; none of its values is echoed in the body except through the separately specified header spans. |
| 5.4 | All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. | 🟢 | Only duration: "00:03" is quoted, and it must be because the value contains a colon; all other values are bare and untrimmed of nothing. |
| 5.5 | The filename of the source ER is stated as “er_filename: [er_filename]” | 🟢 | Line 4: er_filename: cruciferous_vegetables_2026-0903-0002_Opus_ER.md, matching the ER’s own filename frontmatter key. |
| 5.6 | Version of the QRS.md file used to create the document is stated as “qrs_prompt_version: [Version of QRS.md]” | 🟢 | Line 5: qrs_prompt_version: 26.7.02, matching the version badge at the head of QRS.md. |
| 5.7 | Creation date and time of the document is stated as “qrs_creation_date: [YYYY-MMDD-HHMM]” (e.g., 2026-0501-1430) | 🟢 | Line 6: qrs_creation_date: 2026-0903-0324 — correct YYYY-MMDD-HHMM shape. |
| 5.8 | The nickname of the AI used to create the document is stated as “qrs_creator_ai_nickname: [qrs_creator_ai_nickname]” | 🟢 | Line 7: qrs_creator_ai_nickname: Opus. |
| 5.9 | The nickname of the AI is just a single word model name without version, etc. (e.g., Opus, Sonnet, Grok, Gemini, ChatGPT) | 🟢 | “Opus” — one word, no version, no qualifier. |
| 5.10 | The full name of the AI used to create the document is stated as “qrs_creator_ai_fullname: [qrs_creator_ai_fullname]” | 🟢 | Line 8: qrs_creator_ai_fullname: Opus 5. |
| 5.11 | The full name of the AI consists of the [qrs_creator_ai_nickname] and the model version number and no additional qualifier (e.g., Opus 4.6, Sonnet 3.2, Grok 4.5, Gemini 3.1, ChatGPT 5.4) | 🟢 | “Opus 5” = nickname plus version, no context-window or tier qualifier appended. |
| 5.12 | The filename of the document is stated as “qrs_filename: [filename of this document]” | 🟢 | Line 9: qrs_filename: cruciferous_vegetables_2026-0903-0002_Opus_QRS.html, matching the file on disk. |
| 5.13 | All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. | 🟢 | Re-verified across all nine keys including the three appended ones (duration, git_user, git_issue): no stray whitespace, and the single quoted value is quoted for a colon. |
6. Page Title & Header
| # | Description | Result | Comments |
|---|---|---|---|
| 6.1 | [page_title] is set to the [canonical_topic] of the ER frontmatter followed by “ - Quick Reference Sheet” (e.g., “Intervention - Quick Reference Sheet”). The [canonical_topic] is HTML-entity-encoded as needed (e.g., & for &) |
🟢 | Line 22: Cruciferous Vegetables for Health & Longevity - Quick Reference Sheet; the ampersand in the ER canonical_topic is correctly entity-encoded. |
| 6.2 | [header_topic] is set to the [canonical_topic] of the ER frontmatter, with HTML entities encoded as needed (e.g., & for &) |
🟢 | Line 417: Cruciferous Vegetables for Health & Longevity, matching ER frontmatter line 8 with the ampersand encoded. |
| 6.3 | [header_subline_date] is set to [qrs_creation_date reformatted as MM/DD/YYYY] | 🟢 | Line 421: 09/03/2026, the correct MM/DD/YYYY rendering of 2026-0903-0324. |
| 6.4 | [header_subline_model] is set to [qrs_creator_ai_fullname] | 🟢 | Line 425: Opus 5, matching the qrs_creator_ai_fullname frontmatter value exactly. |
| 6.5 | No additional header content appears: no badge, version stamp, AKA / alternate names line, source-AI attribution, audit date, or QRS variant marker. | 🟢 | The header holds only the title and the template subline; the ER’s five alternate names (Brassica Vegetables, Brassicas, Cruciferae, Cole Crops, Mustard Family Vegetables) were correctly not carried over, and no badge or audit stamp was added. |
7. At-A-Glance Section
| # | Description | Result | Comments |
|---|---|---|---|
| 7.1 | [at_a_glance] is dense, execution-oriented summary of the ER Conclusion section |
🟢 | Each of its four sentences tracks one movement of the ER conclusion (lines 491–495): the mechanism, the strongest human findings, the drawbacks, and the animal-only lifespan result. |
| 7.2 | [at_a_glance] is no longer than 60 words | 🟢 | 56 words, counted programmatically on the extracted span text. |
| 7.3 | Every fact in [at_a_glance] is supported by a distinct passage in the ER. | 🟢 | “switch on the body’s own defensive enzymes” ← ER line 491; “small improvements in blood sugar control and a fall in blood pressure over two weeks” ← ER line 493; “digestive discomfort at large portions, some medicines wearing off faster” ← ER line 495; “Lifespan extension shown only in animals” ← ER line 493. |
| 7.4 | It DOES NOT use acronyms or technical classifications that require specialist knowledge, uses plain-language terms instead | 🟢 | No acronym appears. Technical vocabulary is deliberately rendered plainly — “sulfur compounds” for isothiocyanates, “the body’s own defensive enzymes” for Nrf2-driven phase II induction, “some medicines wearing off faster” for CYP1A2 induction. |
| 7.5 | It DOES NOT cite specific trials (names, years, sample sizes, p-values) | 🟢 | No trial name, author, year, enrolment figure or p-value; “two weeks” is a duration carried from the conclusion, not a trial citation. |
| 7.6 | It DOES NOT cite effect sizes, relative risks, or statistical results | 🟢 | No mmHg, mmol/L, hazard ratio, odds ratio or confidence interval, although all are available in the ER magnitude lines. |
8. Contraindications
| # | Description | Result | Comments |
|---|---|---|---|
| 8.1 | The section is derived from the ER Key Interactions & Contraindications section |
🟢 | All four items trace to that section — the radioactive-iodine bullet (ER line 323) and the three “Populations who should avoid” bullets (ER lines 333–335). |
| 8.2 | [stop_items] represent the Contraindications from the ER | 🟢 | Complete and exclusive: the ER’s one absolute contraindication plus its three avoid-populations, with nothing merely cautionary promoted into the stop gate. |
| 8.3 | Individual [stop_items] are formatted as <li></li> | 🟢 | Four discrete <li> elements at QRS lines 570–575, all inside the stop_items span. |
| 8.4 | Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. | 🟢 | The ER’s em-dash clause on the raw-sprout bullet (“— including solid-organ transplant recipients … absolute neutrophil count below 1.0 × 10⁹/L”, ER line 333) is stripped, as is the EU-allergen rationale on the mustard bullet (ER line 335) and the thiocyanate mechanism on the radioiodine bullet (ER line 323). No dash-trailing clause survives. |
| 8.5 | Parenthetical qualifiers from the ER bullet — time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). | 🟢 | The decisive qualifiers all survive: the “(low-iodine preparation window)” time window, the “(urinary iodine below 20 µg/L)” threshold, the “(Brassicaceae)” family qualifier, and the four age/status classes on the raw-sprout item. |
| 8.6 | When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. | N/A | The ER’s Key Interactions & Contraindications section uses no ranking or ordering notation inside parentheses; every parenthetical is a plain example list or a threshold value. |
| 8.7 | The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no population, condition, or scenario for which the intervention should be avoided, deferred, or used only under specialist supervision. |
🟢 | The section is populated, which is correct — the ER names both an absolute contraindication and three avoid-populations. |
| 8.8 | If the section is left empty, an HTML comment inside the [stop_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. | N/A | The section is not empty, so the empty-state comment requirement does not arise. |
9. Key Interactions
| # | Description | Result | Comments |
|---|---|---|---|
| 9.1 | The section is derived from the ER Key Interactions & Contraindications section |
🟢 | All eight items trace to ER lines 313–329. |
| 9.2 | [caution_items] represent the Key Interactions from the ER, excluding any that are already listed as Contraindications | 🟢 | The ER lists nine interaction bullets; all eight non-contraindication bullets are carried, and the ninth (radioactive iodine, ER line 323) is correctly routed to the Contraindications gate instead of being duplicated here. |
| 9.3 | Individual [caution_items] are formatted as <li></li> | 🟢 | Eight discrete <li> elements at QRS lines 583–592, all inside the caution_items span. |
| 9.4 | Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. | 🟢 | Every ER action verdict and mechanism sentence is stripped: “Caution, not avoidance”, “Induction of 20–40% can push plasma levels below effect”, “Sulforaphane lowers hepatic glucose output by a route resembling metformin’s”, and “Caution pending oncologist input” are all absent. Each item is reduced to the drug or exposure class alone. |
| 9.5 | Parenthetical qualifiers from the ER bullet — example drug lists, time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). | 🟢 | Every ER parenthetical is retained in trimmed form rather than dropped: warfarin/phenprocoumon from three; theophylline, clozapine, tizanidine from six; methimazole from two; metformin, sulfonylureas from four; nitrate, garlic, magnesium from four; and both caffeine and paracetamol keep their “(dietary and over-the-counter tablets)” / “(over-the-counter)” qualifiers in full. The “with a narrow margin” severity qualifier on CYP1A2 substrates is also preserved. |
| 9.6 | When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. | N/A | No ranking notation appears in any ER interaction parenthetical; all are already plain comma-separated example lists. |
| 9.7 | The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no interaction, additive effect, or exposure that changes how the intervention is used. |
🟢 | The section is populated, which is correct — the ER documents nine such interactions, including two explicitly additive ones. |
| 9.8 | If the section is left empty, an HTML comment inside the [caution_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. | N/A | The section is not empty, so the empty-state comment requirement does not arise. |
10. Protocol
| # | Description | Result | Comments |
|---|---|---|---|
| 10.1 | The section is derived from the ER Protocol section |
🟢 | All three cells derive from the ER Therapeutic Protocol bullets at lines 357, 359 and 361. |
| 10.2 | The three sets of [action] items cover the three most important actionable implementation aspects from the ER Protocol section |
🟢 | The ER’s sixteen protocol bullets reduce to three delivery routes with an actual dose attached — whole food, home-sprouted broccoli, standardised extract — and those are exactly the three selected. The remaining bullets (chop-and-wait, mustard-seed rescue, half-life, split dosing, genotype, microbiome, sex, age, baseline) are refinements of those three rather than independent implementation aspects. |
| 10.3 | If less that three distinct actionable implementation aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. | N/A | The ER supplies three or more distinct actionable aspects and all three sets are used, so the empty-set rule does not apply. |
| 10.4 | All used [action_#label], [action#value], [action#_sub] items are filled with meaningful content derived from the ER Protocol section. |
🟢 | All nine spans carry substantive ER-derived content: labels verbatim from the ER bold labels, values carrying real doses (3–5 servings weekly; 30–60 g/day fresh 3-day sprouts; 20–60 mg sulforaphane potential daily), and subs carrying the trial dose, the sprout handling requirement and the myrosinase condition. No placeholder survives. |
11. Time to Effect
| # | Description | Result | Comments |
|---|---|---|---|
| 11.1 | The three sets of [time] items cover the three most important time-to-effect aspects from the ER | 🟢 | ER line 420 lists six horizons; the three selected — glucose, blood pressure, liver enzymes — are the three that attach to a graded clinical benefit. The two omitted short horizons (enzyme induction within 24 hours, gut-flora conversion within days) are mechanistic biomarkers, and the omitted long one (cancer, decade-scale) is not actionable on a reference sheet. |
| 11.2 | The sets are picked and ordered by the magnitude of the related benefit | 🟢 | Correct descending order: glucose maps to the sole High-tier benefit (ER line 153), blood pressure to the first-listed Medium benefit (ER line 161), liver enzymes to the last-listed Medium benefit (ER line 179). |
| 11.3 | If less that three distinct time-to-effect aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. | N/A | The ER supplies six time-to-effect horizons and all three sets are used, so the empty-set rule does not apply. |
| 11.4 | All used [time_#label], [time#value], [time#_sub] items are filled with meaningful content derived from the ER. | 🟢 | All nine spans are substantive: values “Twelve weeks”, “Two weeks”, “Two months” match ER line 420 exactly, and each sub adds the ER’s own population context — “Largest where glucose is dysregulated” (ER line 155/234), “24-hour systolic in older adults” (ER line 163), “In fatty liver disease” (ER line 181). |
| 11.5 | If the ER does not provide any information on time to effect, the section is removed completely from the Protocol Panel |
N/A | The ER provides an explicit “Time to effect” bullet (line 420), so the removal condition is not met and the section is correctly retained. |
12. Benefits
| # | Description | Result | Comments |
|---|---|---|---|
| 12.1 | The section is derived from the ER Expected Benefits section |
🟢 | Every listed benefit corresponds to an #### heading under ER Expected Benefits (lines 151–225), in the ER’s own tier and order. |
| 12.2 | Key variables are [benefits_high], [benefits_medium], [benefits_low], [benefits_speculative] | 🟢 | All four spans present and populated at QRS lines 539, 542, 548 and 555. |
| 12.3 | Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. | 🟢 | Each of the twelve benefits is a bare noun phrase. The ER’s magnitude lines — hazard ratio 0.78, the 2.5 mmHg systolic fall, the 63.2% mercapturic-acid rise, the 34% behaviour-scale change — are all absent, as are the trial descriptions. |
| 12.4 | Parenthetical content — including effect sizes, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. | 🟢 | No parentheses appear in any of the four benefit spans; the ER’s “⚠️ Conflicted” flags on glycaemic control, Helicobacter pylori and autism are also correctly dropped as tier-redundant qualifiers. |
| 12.5 | If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. | N/A | All four ER benefit tiers carry at least one item (1 High, 4 Medium, 5 Low, 2 Speculative), so no span needed hiding. |
13. Risks
| # | Description | Result | Comments |
|---|---|---|---|
| 13.1 | The section is derived from the ER Potential Risks & Side Effects section |
🟢 | All seven risks correspond to #### headings under ER lines 249–293, in the ER’s own tiers. |
| 13.2 | Key variables are [risks_high], [risks_medium], [risks_low], [risks_speculative] | 🟢 | All four spans present and populated at QRS lines 604, 610, 613 and 619. |
| 13.3 | Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. | 🟢 | Each risk is a bare noun phrase; the ER’s 20–40% CYP1A2 induction figure, the 150 µg/day vitamin K threshold, the raffinose-fermentation mechanism and the myxedema case report are all absent. |
| 13.4 | Parenthetical content — including frequencies, severity grades, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. | 🟢 | No parentheses appear in any of the four risk spans; the three “⚠️ Conflicted” flags carried by the ER risk headings are correctly dropped. |
| 13.5 | If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. | N/A | All four ER risk tiers carry at least one item (2 High, 1 Medium, 2 Low, 2 Speculative), so no span needed hiding. |
14. Monitoring
| # | Description | Result | Comments |
|---|---|---|---|
| 14.1 | The section is derived from the ER Monitoring section |
🟢 | The table reproduces the ER Monitoring Protocol & Defining Success biomarker table (lines 450–461); the “Why” cells are condensed from the ER’s “Why Measure It?” column and the ER’s fourth “Context/Notes” column is correctly not carried. |
| 14.2 | All measurable/quantifiable biomarkers from the Monitoring section are listed |
🟢 | All ten ER rows are present in ER order: thyroid-stimulating hormone, free thyroxine, urinary iodine concentration, glycated haemoglobin, fasting glucose, home systolic blood pressure, high-sensitivity C-reactive protein, alanine aminotransferase, international normalised ratio, urinary isothiocyanate excretion. Targets match the ER exactly, including the sex-split ALT thresholds and the INR’s “own prescribed target, typically 2.0–3.0”. |
| 14.3 | [monitoring_cadence] is populated with the monitoring cadence/frequency derived from the ER Monitoring section. It is not left with placeholder text or empty. |
🟢 | Populated at QRS lines 764–768 and faithful to ER line 448: blood pressure at 2 and 4 weeks then quarterly; HbA1c and liver panel at 3 and 6 months then 6–12 monthly; thyroid at 3 months and annually where iodine is low or raw intake high; INR 1–2 weeks after a sustained change. |
15. Qualitative Assessment
| # | Description | Result | Comments |
|---|---|---|---|
| 15.1 | The section is derived from the ER Monitoring section |
🟢 | All five items come from the qualitative-markers list at ER lines 465–469, which sits inside Monitoring Protocol & Defining Success. |
| 15.2 | All subjective/qualitative biomarkers from the Monitoring section are listed |
🟢 | All five are carried, none omitted: digestive tolerance, palatability and adherence, perceived caffeine potency, energy and post-meal alertness, and sensitivity to the sulfur taste — each keeping the ER’s own explanatory clause in condensed form. |
Issues 03/09/2026 04:08
Pass rate 100.00%. No issues found.
Issues 03/09/2026 03:59
- 4.3 — Qualitative label paraphrased:
qualitative_item_5(line 801) reads “Sulfur-taste sensitivity”, paraphrasing the ER’s own label “Sensitivity to the sulfur taste” (ER line 469).
Fixes 03/09/2026 03:59
- 4.3 — Qualitative label restored verbatim: Changed
qualitative_item_5from “Sulfur-taste sensitivity” to the ER’s own label “Sensitivity to the sulfur taste”.
Issues 03/09/2026 03:51
- 4.5 — QRS exceeds one A4 page: The sheet’s estimated rendered height is roughly twice the A4 print budget; the Monitoring card (lines 637–793), the eight-item Key Interactions gate (lines 584–599), the Protocol and time-to-effect sub-cells (lines 456–531) and the Benefits “Low” item (lines 550–556) all carry text that wraps to two or three lines where one would do.
Fixes 03/09/2026 03:51
- 4.5 — Monitoring Why/Target cells condensed: Shortened eight biomarker cells so each row wraps to fewer lines, e.g. marker_2_why from “Confirms whether a raised thyroid-stimulating hormone reflects real hormone shortfall” to “Confirms a real hormone shortfall” and marker_10_target from “No established target exists; change from the individual’s own baseline” to “None established; change from own baseline”.
- 4.5 — Monitoring cadence shortened: Rewrote the cadence paragraph to two lines, abbreviating “Glycated haemoglobin” to “HbA1c”, “every 6–12 months” to “6–12 monthly” and “Anticoagulation” to “INR”.
- 4.5 — Key Interaction drug lists trimmed: Trimmed the parenthetical example drugs in five caution items (per item 9.5’s “shortened or trimmed where needed to fit the one-page budget”), e.g. the CYP1A2 list from six named drugs to three, dropping four wrapped lines from the gate.
- 4.5 — Protocol and time-to-effect sub-cells condensed: Cut all three action sub-cells and all three time sub-cells to their load-bearing content, e.g. action_3_sub from “Commercial forms delivering a defined glucoraphanin dose with active myrosinase” to “Defined glucoraphanin dose with active myrosinase”.
- 4.5 — Benefits Low and Speculative tiers tightened: Removed redundant modifiers (“airborne and dietary”, “circulating”, “abdominal”, “age-related”) so the Low item drops from three lines to two and the Speculative item to one.
Issues 03/09/2026 03:44
- 1.3 — Hedge dropped from genotype claim:
qualitative_item_5(line 825) states “strong aversion tracks genotype”, dropping the ER’s hedge at line 469, “strong aversion often tracks genotype”, which strengthens a probabilistic claim into a categorical one.
Fixes 03/09/2026 03:44
- 1.3 — Genotype hedge restored: Changed
qualitative_item_5from “strong aversion tracks genotype” to “strong aversion often tracks genotype”, matching the ER’s hedged wording at line 469.
Issues 03/09/2026 03:36
- 4.5 — Free-text spans not condensed: [monitoring_cadence] (lines 787–792) reproduces the ER’s four-sentence cadence paragraph almost verbatim, the five [qualitative_item_#] spans (lines 800–829) carry full ER sentences, and [action_1_sub] (line 456) repeats a four-vegetable enumeration already implied by “mixed cruciferous vegetables” — together pushing the sheet past its one-page budget instead of being condensed to the per-section budget.
Fixes 03/09/2026 03:36
- 4.5 — Protocol sub condensed: [action_1_sub] dropped the redundant “— broccoli, cabbage, cauliflower, Brussels sprouts —” enumeration, leaving “Trial-level dosing 300 g/day of mixed cruciferous vegetables, split across two meals”.
- 4.5 — Monitoring cadence tightened: [monitoring_cadence] was compressed from the ER’s four-sentence paragraph, shortening the thyroid and anticoagulation clauses (“Thyroid at 3 months and annually, only where iodine intake is low or raw intake high. Anticoagulation 1–2 weeks after any large sustained change.”) without dropping any interval.
- 4.5 — Qualitative items condensed: All five [qualitative_item_#] spans were trimmed from full ER sentences to compact phrases (e.g., “Sensitivity to the sulfur taste: strong aversion often tracks genotype and predicts poor long-term adherence” → “Sulfur-taste sensitivity: strong aversion tracks genotype and predicts poor long-term adherence”), preserving every marker.
Issues 03/09/2026 03:29
- 7.4 — Clinical-register word in At-A-Glance: “faster clearance of a few medicines” uses “clearance” in its pharmacokinetic sense, an ordinary-looking clinical-register term that a non-specialist would not use unprompted with that exact meaning.
Fixes 03/09/2026 03:29
- 7.4 — Plain-language At-A-Glance wording: Replaced “faster clearance of a few medicines” with “some medicines wearing off faster” in [at_a_glance], removing the pharmacokinetic sense of “clearance”; the summary remains within the 60-word budget at 56 words.