Cyanidin-3-Glucoside for Health & Longevity - Quick Reference Sheet

Cyanidin-3-Glucoside for Health & Longevity

Created on 07/18/2026 – Quick Reference based on Evidence Review created using AI4L / Opus 4.8 Audit

A widely eaten plant pigment from dark berries, black rice, and purple grains. Its strongest support is for modest blood-vessel and heart benefits, with clearer effects in people who start with elevated risk markers. Effects on blood sugar, blood fats, and inflammation are smaller. Safety is reassuring; brain, weight, cancer, and longevity claims remain unproven. (Full Review)

Protocol

Dose
~320 mg/day
Standardized anthocyanins; isolated C3G ~100–320 mg/day
Timing
With meals
Split dosing (e.g., twice daily) preferred given short half-life
Form
Isolate or whole-food
Standardized C3G/anthocyanin capsules, or anthocyanin-rich foods/extracts
Time to effect
Vascular function
Hours
Improved arterial responsiveness after a dose
Blood lipids
4–12 weeks
Measurable with consistent daily use
Blood sugar
4–12 weeks
Glycemic markers with consistent use

Benefits

Contraindications
  • Pregnancy or breastfeeding
  • Bleeding disorders or scheduled surgery
Key Interactions
  • Antidiabetic drugs (insulin, metformin, sulfonylureas, SGLT2 inhibitors)
  • Anticoagulants/antiplatelets (warfarin, apixaban, rivaroxaban, aspirin, clopidogrel)
  • Antihypertensives (ACE inhibitors, calcium channel blockers)
  • NSAIDs (ibuprofen, naproxen)
  • Glucose-, pressure-, or platelet-active supplements (berberine, alpha-lipoic acid, fish oil, vitamin E, garlic, ginkgo)

Risk & Side Effects

  • High:
  • Medium:
  • Low: Gastrointestinal discomfort; additive blood-sugar lowering; theoretical bleeding / antiplatelet additivity
  • Speculative: Drug–metabolism interactions; pro-oxidant effects at supraphysiologic doses

Monitoring

Marker Target Why
LDL cholesterol < 100 mg/dL Primary lipid target C3G may improve
HDL cholesterol > 50 mg/dL (women), > 40 mg/dL (men) May rise with anthocyanins
Triglycerides < 90 mg/dL Often responsive to anthocyanins
Fasting glucose 75–90 mg/dL Tracks glycemic effect
HbA1c < 5.4% Average blood sugar over ~3 months
hs-CRP < 1.0 mg/L Captures anti-inflammatory effect
Blood pressure < 120/80 mmHg Detects modest pressure-lowering effect
Fasting insulin < 8 µIU/mL Reflects insulin sensitivity change

Cadence: Recheck at 8–12 weeks after a stable dose, then every 6–12 months

Qualitative Assessment

  • Energy and post-meal stability
  • Cognitive clarity
  • Exercise recovery
  • Visual comfort