Everyday drinking water with most of its heavy hydrogen removed. The strongest interest is as an add-on in cancer care, with weaker signals for blood-sugar control and animal hints on mood, memory, and aging. It appears safe short-term, but human evidence is thin, unreplicated, and long-term safety is unknown. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Fasting glucose | 70–85 mg/dL | Tracks blood-sugar control, the best-supported metabolic endpoint |
| Fasting insulin | 2–5 µIU/mL | Detects insulin resistance, a proposed target of deuterium depletion |
| HbA1c | < 5.4% | 3-month average blood sugar; smooths daily variation |
| hs-CRP | < 1.0 mg/L | General marker of body-wide inflammation; context for oxidative-stress claims |
| Disease-specific marker (e.g., PSA in prostate cancer) | Per condition | Directly tracks the endpoint studied in the relevant trial |
Cadence: Reassess metabolic endpoints at ~8–12 weeks, then every 3–6 months; in disease contexts, follow the treating physician's schedule.