A lab-made leave-on skincare molecule that calms skin inflammation and helps slow sun-driven collagen breakdown. In one small human study a 1% gel improved wrinkles, hydration, and texture, and it is well tolerated. Nearly all evidence comes from the developer and has not been independently confirmed — promising but early. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Skin hydration (corneometry) | Higher than baseline | Tracks the hydration benefit |
| Transepidermal water loss (TEWL) | Lower than baseline | Reflects barrier integrity |
| Erythema index (redness) | Lower than or equal to baseline | Captures the redness-soothing effect |
| Wrinkle depth / texture score | Improved versus baseline | Primary appearance endpoint |
Cadence: Baseline, then ~4, 8, and 12 weeks; every 3–6 months thereafter if use continues