Fadogia agrestis is a West African herb popular for raising testosterone naturally. Its reputation rests almost entirely on one set of rat experiments; no completed human study confirms it works. The same animal research showed signs of injury to the testes, liver, and kidneys. Possible benefits are promising but unproven, while safety questions remain real and unanswered. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Total testosterone | ~500–900 ng/dL (men) | Primary target outcome |
| Free testosterone | ~15–25 pg/mL (men) | Reflects biologically active hormone |
| Estradiol (E2) | ~10–30 pg/mL (men) | Detects excess conversion of testosterone to estrogen |
| ALT / AST | ALT ~10–26 U/L; AST ~10–26 U/L | Detects liver-cell injury flagged in animal data |
| Gamma-glutamyl transferase (GGT) | <25 U/L | Sensitive marker of liver/biliary stress |
| Creatinine / eGFR | Creatinine ~0.7–1.1 mg/dL; eGFR >90 mL/min/1.73 m² | Detects kidney injury flagged in animal data |
Cadence: Baseline before starting, again at ~4–8 weeks, then periodically (e.g., every 3–6 months) if use continues across cycles