Fisetin is a plant pigment and one of the most potent natural clearers of worn-out cells that build up with age and fuel inflammation. In older mice it improved blood-vessel function, strength, and lifespan, but human evidence is early and limited, oral absorption is poor, and long-term safety is uncharacterized. A low-cost, low-risk compound with an unproven real-world payoff. (Full Review)

Protocol

Standard Research Dose

~20 mg/kg/day

~1,400 mg/day for a 70 kg adult, on 2 consecutive days

Schedule

Intermittent pulses

"Hit-and-run" cycles (e.g. monthly, or 1-week-on/2-weeks-off), not continuous daily use

Administration

With a fat-containing meal

Improves absorption; splitting the dose across meals may help maintain exposure

Time to effect

Biomarker Effects

Weeks

Measured in research over weeks via biomarkers; no perceptible short-term effect should be expected

Benefits

High: Clearance of senescent cells in preclinical models

Medium: Extension of healthspan and lifespan; improved vascular and arterial function; improved physical function and reduced frailty

Low: Bone metabolism support; neuroprotection and cognitive support

Speculative: Metabolic and anti-cancer effects; adjunctive benefit in acute inflammatory illness

Contraindications

Pregnancy or breastfeeding

Bleeding disorders or scheduled surgery (hold 1–2 weeks before)

Hormone-sensitive cancers

Significant liver or kidney impairment (eGFR indicating moderate-to-severe CKD, or Child-Pugh Class B–C)

Key Interactions

Anticoagulant and antiplatelet drugs (warfarin, apixaban, clopidogrel, aspirin)

CYP3A4 substrates (statins, certain calcium-channel blockers, some immunosuppressants)

Drugs cleared by glucuronidation/sulfation (acetaminophen, some hormones)

Over-the-counter NSAIDs (ibuprofen, naproxen)

Other senolytics and flavonoid supplements (quercetin, dasatinib, curcumin)

Supplements with additive antiplatelet or anti-inflammatory effects (fish oil, high-dose vitamin E, ginkgo, garlic extract)

Risk & Side Effects

Medium: Limited long-term safety data

Low: Mild gastrointestinal effects; potential drug-interaction risk via metabolic enzymes

Speculative: Theoretical bleeding and antiplatelet interaction; theoretical hormonal or estrogenic activity

Monitoring

Marker	Target	Why
ALT / AST	~10–26 U/L	Liver clears fisetin; detects organ stress
eGFR	>90 mL/min/1.73m²	Kidney handles clearance; flags impairment
hs-CRP	<1.0 mg/L	General marker of the systemic inflammation senolytics aim to reduce
IL-6	Low end of assay range	A SASP-related inflammatory signal relevant to senescence
Fasting glucose & HbA1c	Glucose 70–85 mg/dL; HbA1c <5.4%	Tracks metabolic aging, a domain of interest
CBC	Within normal limits	Safety check given theoretical effects on blood cells

Cadence: Baseline before starting; safety labs at ~3 months after initiating periodic dosing, then every 6–12 months while use continues

Qualitative Assessment

Energy levels: subjective day-to-day energy and vitality, tracked over weeks to months
Physical function: grip strength, walking speed, or general stamina
Cognitive clarity: subjective focus and memory
Recovery and inflammation symptoms: joint comfort and recovery from exertion

Fisetin for Health & Longevity

Protocol

Benefits

Risk & Side Effects

Monitoring

Qualitative Assessment