FOXO4-DRI is a laboratory-made peptide, sold online as a research chemical, designed to make worn-out cells that build up with age destroy themselves. In aged mice it restored kidney filtration and testosterone output; no person has taken it in a registered study. Concerns include loss of cells holding tissues together and worsened lung blood-vessel disease in mice, its action on the body's main defence against cancer, and possibly contaminated supply. (Full Review)
| Marker | Target | Why |
|---|---|---|
| ALT and AST | ALT 7–55 U/L; AST 8–48 U/L | Safety check for liver injury |
| Serum creatinine with eGFR | Creatinine 0.59–1.04 mg/dL (women), 0.74–1.35 mg/dL (men) | Kidney filtration, the clearest change in treated mice |
| Blood urea nitrogen | 6–24 mg/dL | Primary kidney readout in the animal work |
| Platelet count | 150–450 × 10⁹/L | Safety check for platelet loss |
| High-sensitivity C-reactive protein | No established target; track change from the individual's own baseline | Inflammatory signalling from senescent cells |
| p16INK4a messenger RNA in CD3-positive blood T cells | No established target; track change from the individual's own baseline | Senescent-cell burden |
| Total testosterone (males) | 264–916 ng/dL | Testosterone recovery seen in aged male mice |
Cadence: Baseline before any exposure, then at 2 weeks after a course, at 3 months, and every 3 to 6 months thereafter