GB-115 is a Russian-designed prescription oral medication built to block a fear-related gut-and-brain messenger, aimed at stress-linked anxiety and fatigue. Manufacturer-paid trials point to meaningful short-term anxiety relief at the labeled dose, with fatigue improving alongside and mostly mild side effects. No independent group outside Russia has tested it, nothing is known about use beyond four weeks, and the evidence speaks to short-term relief rather than broader longevity effects. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Anxiety score (Hamilton Anxiety Rating Scale, or a validated self-rated questionnaire) | No established target; track change from own baseline | Expected to change (efficacy) |
| Fatigue score (Multidimensional Fatigue Inventory) | No established target; track change from own baseline | Expected to change (efficacy) |
| Blood pressure | No established target; track change from own baseline | Safety check |
| Urine protein (dipstick) | Negative | Safety check |
| Visual acuity (eye chart) | 20/20 (6/6) or better | Safety check |
| Pregnancy test (urine human chorionic gonadotropin) | Negative | Safety check |
Cadence: Baseline before starting; anxiety and fatigue scores and blood pressure at day 14 and day 28; urine protein at day 28; vision checks at any change in sight; repeat anxiety score 1–2 weeks after stopping