GHRP-6 for Health & Longevity - Quick Reference Sheet

GHRP-6 for Health & Longevity

Created on 10/02/2026 – Quick Reference based on Evidence Review created using AI4L / Opus 5.5 – Audit

GHRP-6 is a synthetic peptide that copies a natural hunger hormone to make the body release its own growth hormone; health-focused adults use it hoping to keep muscle and resilience with age. The hormone rise is reliable, but real-world benefits are unproven. Risks appear modest but poorly measured: related drugs impaired blood-sugar handling, caused strong hunger and were linked to swelling; no long-term human safety study exists. (Full Review)

Protocol

Fixed-dose clinic regimen
100 µg subcutaneous injection three times daily
Given with GHRP-2 and sermorelin in a clinic series
Weight-based dose
1 µg/kg
The intravenous dose used in trials and diagnostic testing; self-administered subcutaneously
Time of day
Bedtime, empty stomach
Favored to add to the natural night-time growth hormone pulse
Time to effect
Body composition
Months
By analogy with ibutamoren; DEXA (body-composition scan) after 6–12 months
IGF-1 rise
One to several days
Rechecked at 6–8 weeks
Growth hormone peak
About 45 minutes
Returns to baseline within about 3.5 hours of a dose

Benefits

Contraindications
  • Active cancer or a recent cancer history (theoretical)
  • Acromegaly or other pituitary tumors (theoretical)
  • Cushing's disease
  • Poorly controlled diabetes
  • Congestive heart failure
  • Pregnant or breastfeeding women, children and adolescents (theoretical; no safety data)
  • Competitive athletes subject to anti-doping testing
Key Interactions
  • GHRH analogs (sermorelin, tesamorelin, CJC-1295): Monitor
  • Other GH secretagogues (ibutamoren, ipamorelin, GHRP-2, hexarelin): Avoid (theoretical)
  • Growth hormone or IGF-1 injections (somatropin, mecasermin): Avoid (theoretical)
  • Glucocorticoids (dexamethasone, prednisone): Monitor
  • Anticholinergic drugs (atropine): Monitor
  • Blood-pressure drugs: prazosin (Monitor); propranolol, clonidine (no interaction)
  • Cholinergic drugs (pyridostigmine): Monitor
  • Estrogen-lowering drugs (anastrozole, tamoxifen): Monitor
  • Diabetes medicines (insulin, metformin, sulfonylureas such as glipizide): Caution (theoretical for metformin, sulfonylureas)
  • Somatostatin analogs (octreotide, lanreotide): Caution (theoretical)
  • Lipid-lowering drugs that cut free fatty acids (acipimox): Monitor
  • Over-the-counter medicines (high-dose niacin, vitamin B3): Caution (theoretical)
  • Arginine supplements: Monitor
  • Supplements that raise GH (alpha-GPC, ornithine): Monitor (theoretical)
  • High-sugar meals and drinks: Monitor

Risk & Side Effects

  • High:
  • Medium:
  • Low: Reduced Insulin Sensitivity and Higher Blood Sugar; Increased Hunger; Fluid Retention, Muscle Pain and Heart-Failure Signal; Facial Flushing; Serious Adverse Events in Stroke Patients; Cancer Risk and Pro-Growth Signaling; Injection-Site Reactions
  • Speculative: Raised Cortisol, ACTH and Prolactin; Contaminated or Mislabeled Products; Receptor Desensitization

Monitoring

Marker Target Why
IGF-1 Age- and sex-specific laboratory range Expected to change; confirms effect, flags excess
Fasting glucose 70–99 mg/dL Safety check; rise reduces or stops use
HbA1c 4.0–5.6% Safety check; rise stops or changes use
Prolactin Men 4–15 ng/mL; women 4–23 ng/mL Safety check; marked rise stops use
Morning cortisol About 6–19 µg/dL at 8 a.m. Safety check; persistent rise changes use
PSA (men) 0–4.0 ng/mL Safety check; rise stops use, prompts evaluation

Cadence: Baseline (fasting, morning, at least 24 hours after any injection); IGF-1, fasting glucose and prolactin at 6–8 weeks, then every 3 months during use and 4 weeks after stopping; HbA1c every 3 months; PSA every 6–12 months; morning cortisol if fatigue, sleep disturbance or weight gain appear

Qualitative Assessment

  • Hunger level and daily food intake
  • Sleep quality and night-time awakenings
  • Energy, recovery from training and perceived strength
  • Ankle or hand swelling, tingling fingers, joint aches
  • Injection-site redness or pain
  • Body weight and waist circumference trend