GHRP-6 for Health & Longevity

Created on 11/05/2026 – Quick Reference based on Evidence Review created using AI4L / Opus 5.5 – Audit

GHRP-6 is a synthetic peptide, injected to make the body release short bursts of its own growth hormone. That hormone effect is well proven, but no benefit for health or lifespan has been shown; its best-supported use is as a test for growth hormone deficiency. It also raises stress and milk-producing hormones and appetite, is flagged by regulators for weakening blood sugar control, and reaches users through unregulated suppliers. (Full Review)

Protocol

Self-administration regimen
100–300 µg subcutaneously or intramuscularly
Two or three times daily, fasted, in 8–12-week cycles; the protocol circulating in unregulated channels, catalogued but not endorsed in a published review. No approved regimen exists.
Diagnostic regimen
1 µg/kg intravenously
Alone or with GHRH 1 µg/kg, growth hormone sampled over 90–120 minutes; the best-validated use.
Best time of day
Bedtime
Aligns the pulse with nocturnal growth hormone release; morning dosing suits those who find sleep disturbed.
Time to effect
Growth hormone release
Immediate
Peak at 45 minutes after a 30-minute infusion
IGF-1 shift
Days
Needs days of repeated dosing
Body composition
Never demonstrated
No GHRP-6 trial has measured body composition

Benefits

Contraindications
  • People with acromegaly
  • People with corticotropin-dependent Cushing's disease or any cause of cortisol excess
  • People with active or recently treated cancer
  • People with uncontrolled diabetes
  • People with active proliferative diabetic retinopathy
  • Pregnant and breastfeeding women
Key Interactions
  • GHRH analogues (sermorelin, tesamorelin): synergistic growth hormone discharge
  • Anticholinergic drugs (atropine, scopolamine): loss of effect
  • Cholinesterase inhibitors (pyridostigmine): amplified hormonal effect
  • Glucocorticoids (dexamethasone): unpredictable response during steroid courses
  • Insulin and glucose-lowering agents (insulin, glipizide): response varies with glycaemic state
  • Growth hormone receptor antagonists (pegvisomant): acute insulin resistance; avoid
  • Lipid-lowering agent acipimox: a larger hormonal pulse than expected from the dose
  • Antifungal ketoconazole: an altered response during prolonged antifungal therapy
  • Arginine supplements: a larger hormonal pulse in older users
  • Somatostatin and its analogues (octreotide): a blunted growth hormone response
Theoretical (inferred from mechanism)
  • Other ghrelin-receptor agonists (ipamorelin, hexarelin): additive hormonal effects and faster receptor desensitisation
  • Agents that raise prolactin (risperidone, haloperidol): additive prolactin elevation
  • Over-the-counter anticholinergic antihistamines (diphenhydramine): a blunted growth hormone pulse when taken close to dosing
  • Thyroid hormone replacement (levothyroxine): a smaller growth hormone pulse if replacement is over-dosed

Risk & Side Effects

  • High: Elevated corticotropin and cortisol
  • Medium: Elevated prolactin
  • Low: Weakened insulin sensitivity and higher blood glucose; increased appetite and weight gain; fluid retention, musculoskeletal symptoms and a heart failure signal; transient facial flushing; impure, mislabelled or immunogenic product
  • Speculative: Promotion of existing tumour growth; coronary vessel narrowing

Monitoring

Marker Target Why
Insulin-like growth factor 1 (IGF-1) Age- and sex-specific laboratory reference interval Main readable consequence of raised growth hormone
Fasting plasma glucose 70–99 mg/dL (3.9–5.5 mmol/L) Safety check; a rise is grounds to stop
Glycated haemoglobin 4.0–5.6% Detects sustained glucose drift
Fasting insulin About 2.6–24.9 mU/L, laboratory-specific Rises before glucose when insulin sensitivity falls
Morning serum cortisol 5–25 µg/dL (138–690 nmol/L) GHRP-6 directly stimulates the stress-hormone axis
Prolactin Men 4–15 ng/mL; women 4–23 ng/mL Sustained elevation suppresses sex-hormone output

Cadence: Baseline fasting and in the morning before use; repeated at about four weeks, every three to six months during continued use, and whenever appetite, swelling or sleep changes markedly.

Qualitative Assessment

  • Appetite and hunger intensity, particularly in the hours after dosing
  • Sleep quality, time to fall asleep, and night-time awakenings
  • Swelling of hands, ankles or feet, including tightness of rings and shoes
  • Joint and muscle discomfort, and numbness or tingling in the hands
  • Injection-site redness, pain or lumps, which may signal product impurity