Audit: QRS - GHRP-6 for Health & Longevity

Audit conducted on 07/08/2026 08:47 using AI4L / Opus 5

Iterations

Summary

Items Count
Total 91
Passed 81
Failed 0
N/A 10
Pass Rate 100.00%
  • Total = Passed + Failed + N/A
  • Pass Rate = Passed / (Passed + Failed) × 100
  • N/A items are excluded from the pass rate calculation

1. General Rules

# Description Result Comments
1.1 Every claim, magnitude, label, recommendation, and statement in the QRS is literally supported by content in the source ER. 🟢 Protocol cells (100 µg SC, 2–3× daily, empty stomach), time-to-effect values (30–45 min, 20–30 min, 8–12 weeks), all benefit/risk tier entries, all 12 contraindications, all 12 interactions, all 9 biomarkers with targets, cadence, and all 9 qualitative markers trace to ER lines 396–404, 451, 153–213, 237–303, 323–362, 481–501.
1.2 Where the ER uses cautious phrasing (“not formally studied”, “None documented in human trials to date”, “theoretical concern”, “data are limited”), the QRS uses the same phrasing. 🟢 At-a-glance retains “That pulse is well established; almost everything beyond it is unresolved” from ER Conclusion (line 527); no hedged ER statement is rendered as settled.
1.3 The QRS never strengthens an ER claim (e.g., “not formally studied” → “not required”) or softens one (e.g., “do not use during pregnancy” → “use with caution during pregnancy”). 🟢 “Pregnancy and lactation” and “Recombinant human growth hormone” remain absolute stop items, matching ER lines 341 and 360.
1.4 The QRS does not relabel an ER fact under a different decision category. A “Benefit-Modifying Factor” from ER section is not surfaced as a “Caution”; a “Risk-Modifying Factor” is not surfaced as a “Side Effect”; etc. 🟢 Contraindications and Key Interactions both derive from the ER Key Interactions & Contraindications section only; no Benefit- or Risk-Modifying Factor content is surfaced as a gate item.
1.5 PubMed IDs, study citations, expert names, clinical trial identifiers (NCT*), and brand names appear in the QRS only if they appear in the source ER for the same fact. 🟢 No PMIDs, NCT identifiers, author names, or trial names appear anywhere in the QRS; all named drugs (octreotide, semaglutide, MK-677, etc.) appear in the ER for the same interaction.
1.6 The QRS does not introduce new attributions. 🟢 No attributions of any kind are present.

2. Focus, Tone & Audience

# Description Result Comments
2.1 The QRS follows the tone of the ER, which is determined by the ER’s own language, phrasing, and framing. 🟢 Sober, evidence-weighted register matching the ER; the at-a-glance mirrors the ER Conclusion’s balance of established pulse against unresolved downstream effects.
2.2 The tone of the QRS is simultaneously expert, accessible, objective, and data-driven, but also empowering and encouraging 🟢 Presents thresholds, targets, and tiers without alarmism or exhortation; content is decision-enabling.
2.3 The QRS reads as a trusted, knowledgeable guide rather than a prescriptive doctor 🟢 No imperatives directed at a patient; sections describe what is measured and what is documented.
2.4 The QRS avoids language that implies medical or clinical advice 🟢 Gate and monitoring entries are stated as facts and ranges, not instructions.
2.5 The QRS “presents information” instead of “providing guidance”, “recommending”, or “advising” 🟢 No “recommended”, “should”, or “advised” constructions in the populated spans.
2.6 The QRS never addresses “the reader” directly — it presents evidence, not guidance 🟢 No second-person pronouns anywhere in the document.
2.7 The QRS is written in plain language, avoiding unnecessary medical jargon 🟢 Technical terms retained (Child-Pugh Class C, apnea-hypopnea index, prednisone-equivalent) are the threshold qualifiers required by items 8.5/9.5, not gratuitous jargon.
2.8 Information is presented in a concise and very compact manner 🟢 Benefits and risks are reduced to bare tier headings; gate items carry no rationale; protocol subs are one sentence each.
2.9 It DOES NOT address the reader directly 🟢 Confirmed — no direct address in any span.
2.10 The target audience is health- and longevity-oriented adults who are risk-aware, proactive, and actively seeking to optimize health or apply the intervention under review. 🟢 Functional biomarker targets (fasting insulin 2–5 µIU/mL, HbA1c 4.8–5.3%) and third-party verification framing address exactly this audience.
2.11 The target audience is willing to employ lifestyle and behavioral changes as well as follow protocols that may be inconvenient, costly, or require effort. 🟢 2–3× daily fasted subcutaneous dosing, 9-marker panel, and weekly waist measurement assume a high-effort audience.
2.12 The document is NOT written for the general population, who are unwilling to employ lifestyle and behavioral changes or follow protocols that may be inconvenient, costly, or require effort. 🟢 Content depth and monitoring burden are well beyond a general-population sheet.
2.13 Framing, takeaways, and risk/benefit weighting throughout the document reflect this audience, including where an intervention’s signal for the average person differs from its signal for this audience. 🟢 Appetite stimulation appears as a Medium benefit and simultaneously as the leading High risk, reflecting the ER’s point that the effect is unwanted for body-composition-conscious adults.
2.14 The document’s own voice frames usage in longevity terms, not “anti-aging” (e.g., “anti-aging clinics”, “anti-aging community”, “anti-aging medicine”). Proper names that contain “anti-aging” (e.g., “American Academy of Anti-Aging Medicine”) are quoted verbatim. 🟢 “anti-aging” does not occur; the speculative benefit uses “biological aging”.
2.15 The document’s own voice uses formal clinical and scientific terminology, not colloquial or consumer-grade language (e.g., “oral medication” not “pill(s)”; “injection” not “shot”; “adverse event” not “bad reaction”). Direct quotes from sources are exempt. 🟢 “subcutaneously”, “peripheral edema”, “receptor desensitization”, “cytoprotection” used throughout; the plain-language rendering in the at-a-glance is mandated by item 7.4 and taken from the ER Conclusion.

3. Template Integrity

# Description Result Comments
3.1 The following labels and headings on the QRS are fixed and not modified: Card and section headings: “Protocol”, “Time to effect”, “Benefits”, “Risk & Side Effects”, “Monitoring”, “Qualitative Assessment”; Gate headings: “Contraindications”, “Key Interactions”; Tier labels: “High”, “Medium”, “Low”, “Speculative”; Table column headers in Monitoring: “Marker”, “Target”, “Why” 🟢 All fourteen fixed strings verified byte-identical to the template at QRS lines 444, 484, 529, 554, 578, 607, 632, 636–638, 767.
3.2 All “” from the [qrs_template] are present in the the QRS. 🟢 All 34 template span names present; the repeatable marker_#_* and qualitative_item_# spans are expanded to 9 instances each as designed.
3.3 Spans that are not addressed in a checklist item are left unchanged 🟢 Structural diff against the template shows the CSS block byte-identical and only the metadata block plus expected span content changed; <span website="evidence_review">, <span website="audit">, <span website="full_review">, and the footer disclaimer are untouched.

4. Formatting

# Description Result Comments
4.1 When the source ER section is empty, the QRS uses the ER’s own empty-state phrasing verbatim. Typical phrasings are “None documented in human trials to date” and “Not formally studied” N/A No source ER section drawn on by the QRS is empty.
4.2 Where the ER presents a bulleted item as “Label: content”, the QRS uses the ER’s bold label verbatim as the cell or row label. 🟢 Monitoring row labels (“IGF-1”, “IGF binding protein 3”, “Morning cortisol”, “TSH and free T4”, “Apolipoprotein B”) are the ER biomarker table’s own labels verbatim (ER lines 481–489).
4.3 Labels are not paraphrased, abbreviated, or invented. 🟢 Marker names and tier labels match the ER; protocol and time-to-effect cell labels are the standard fixed template cell labels populated per items 10.2 and 11.1.
4.4 The QRS DOES NOT use emoji indicators (no 🟩, 🟥, 🟨, etc.). Color and emphasis are conveyed through CSS and bold labels. 🟢 No emoji characters occur in the file; the ER’s 🟩/🟥/🟨 tier markers and ⚠️ Conflicted flags were correctly stripped.
4.5 The QRS is designed to render on one A4 page. Any section that has more content in the ER than fits the per-section budget is condensed by the LLM, not extended onto a second page. 🟢 Every section is condensed to its checklist floor: benefits and risks are bare tier headings with all parentheticals stripped, gate items carry no rationale or trailing clauses, protocol subs are single sentences, and the cadence is a single compressed line. Remaining length is driven entirely by the completeness requirements of items 8.2, 9.2, 14.2, and 15.2, which forbid dropping items.

5. Metadata

# Description Result Comments
5.1 The metadata is placed inside a single HTML comment that is the first element after “<!doctype html>” and before any other comment, head, or body content. 🟢 Lines 2–14, immediately after <!doctype html> on line 1 and before the template’s own comment on line 16.
5.2 Inside that HTML comment the YAML block is delimited by a line “—” opening and a line “—” closing. Text before the opening “—” is permitted but is not parsed as YAML. 🟢 Opening --- on line 3, closing --- on line 13; the lead-in text on line 2 precedes the opening delimiter.
5.3 The metadata is not visible in any rendered view of the QRS and is not surfaced by any other element on the sheet. 🟢 Enclosed entirely in an HTML comment; no metadata value is repeated in the header, footer, or any span.
5.4 All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. 🟢 Only duration: "00:03" is quoted, and it contains a colon requiring YAML quoting; all other values are bare and trimmed.
5.5 The filename of the source ER is stated as “er_filename: [er_filename]” 🟢 Line 4: er_filename: ghrp_6_2026-0807-0333_Opus_ER.md.
5.6 Version of the QRS.md file used to create the document is stated as “qrs_prompt_version: [Version of QRS.md]” 🟢 Line 5: qrs_prompt_version: 26.7.02, matching the QRS.md version badge.
5.7 Creation date and time of the document is stated as “qrs_creation_date: [YYYY-MMDD-HHMM]” (e.g., 2026-0501-1430) 🟢 Line 6: qrs_creation_date: 2026-0807-0837, correct format.
5.8 The nickname of the AI used to create the document is stated as “qrs_creator_ai_nickname: [qrs_creator_ai_nickname]” 🟢 Line 7: qrs_creator_ai_nickname: Opus.
5.9 The nickname of the AI is just a single word model name without version, etc. (e.g., Opus, Sonnet, Grok, Gemini, ChatGPT) 🟢 “Opus” — single word, no version or qualifier.
5.10 The full name of the AI used to create the document is stated as “qrs_creator_ai_fullname: [qrs_creator_ai_fullname]” 🟢 Line 8: qrs_creator_ai_fullname: Opus 5.
5.11 The full name of the AI consists of the [qrs_creator_ai_nickname] and the model version number and no additional qualifier (e.g., Opus 4.6, Sonnet 3.2, Grok 4.5, Gemini 3.1, ChatGPT 5.4) 🟢 “Opus 5” — nickname plus version only, no context-window or tier qualifier.
5.12 The filename of the document is stated as “qrs_filename: [filename of this document]” 🟢 Line 9: qrs_filename: ghrp_6_2026-0807-0333_Opus_QRS.html, matching the file on disk.
5.13 All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. 🟢 Re-verified across all nine keys including git_user and git_issue; no stray whitespace or unnecessary quoting.

6. Page Title & Header

# Description Result Comments
6.1 [page_title] is set to the [canonical_topic] of the ER frontmatter followed by “ - Quick Reference Sheet” (e.g., “Intervention - Quick Reference Sheet”). The [canonical_topic] is HTML-entity-encoded as needed (e.g., &amp; for &) 🟢 Line 22: GHRP-6 for Health &amp; Longevity - Quick Reference Sheet, matching ER canonical_topic with the ampersand encoded.
6.2 [header_topic] is set to the [canonical_topic] of the ER frontmatter, with HTML entities encoded as needed (e.g., &amp; for &) 🟢 Line 417: GHRP-6 for Health &amp; Longevity.
6.3 [header_subline_date] is set to [qrs_creation_date reformatted as MM/DD/YYYY] 🟢 Line 421: 08/07/2026, correctly derived from qrs_creation_date: 2026-0807-0837.
6.4 [header_subline_model] is set to [qrs_creator_ai_fullname] 🟢 Line 425: Opus 5, matching the frontmatter value.
6.5 No additional header content appears: no badge, version stamp, AKA / alternate names line, source-AI attribution, audit date, or QRS variant marker. 🟢 Header contains only the title and the template subline; the ER’s long “Also known as” list was correctly not carried over.

7. At-A-Glance Section

# Description Result Comments
7.1 [at_a_glance] is dense, execution-oriented summary of the ER Conclusion section 🟢 Condenses ER lines 527–531 into mechanism, evidence status, dominant adverse effects, and the source-concentration caveat.
7.2 [at_a_glance] is no longer than 60 words 🟢 59 words.
7.3 Every fact in [at_a_glance] is supported by a distinct passage in the ER. 🟢 Mechanism → ER line 527; “well established / unresolved” → line 527; hunger, stress hormone, blood sugar, fluid retention → line 529 and Risks headings at lines 237–259; single institute → line 531.
7.4 It DOES NOT use acronyms or technical classifications that require specialist knowledge, uses plain-language terms instead 🟢 No acronyms; “ghrelin” rendered as “the stomach’s hunger hormone”, “GHS-R1a”/”cortisol” avoided in favour of “stress-hormone output”, “glucose” as “blood sugar”.
7.5 It DOES NOT cite specific trials (names, years, sample sizes, p-values) 🟢 No trial names, years, sample sizes, or p-values.
7.6 It DOES NOT cite effect sizes, relative risks, or statistical results 🟢 No numeric effect sizes or statistics of any kind.

8. Contraindications

# Description Result Comments
8.1 The section is derived from the ER Key Interactions & Contraindications section 🟢 All 12 stop items map to ER lines 323, 341, and 353–362.
8.2 [stop_items] represent the Contraindications from the ER 🟢 All ten entries of the ER’s “Populations who should avoid this intervention” list plus the two absolute-avoid drug interactions (recombinant human growth hormone, somatostatin analogues) are present.
8.3 Individual [stop_items] are formatted as <li></li> 🟢 Twelve discrete <li> elements at QRS lines 557–573.
8.4 Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. 🟢 ER rationales stripped throughout (e.g., “given the mitogenic profile of IGF-1”, “where no safety data of any kind exist”, “since growth hormone secretagogues are prohibited… under class S2”); no dash-trailing clauses remain.
8.5 Parenthetical qualifiers from the ER bullet — time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). 🟢 “remission for less than 5 years”, “hemoglobin A1c above 7.5% or fasting glucose persistently above 126 mg/dL”, “apnea-hypopnea index of 15 or more events per hour”, “roughly 7.5 mg prednisone-equivalent daily”, “Child-Pugh Class C”, “New York Heart Association Class IV” all retained.
8.6 When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. N/A The ER uses no ranking notation inside parentheses in its contraindication entries.
8.7 If no [stop_items] are present the section is left empty N/A Stop items are present.

9. Key Interactions

# Description Result Comments
9.1 The section is derived from the ER Key Interactions & Contraindications section 🟢 All 12 caution items map to ER lines 325–349.
9.2 [caution_items] represent the Key Interactions from the ER, excluding any that are already listed as Contraindications 🟢 All 12 remaining ER interaction bullets are present; somatostatin analogues and recombinant human growth hormone are correctly excluded here as they sit in Contraindications.
9.3 Individual [caution_items] are formatted as <li></li> 🟢 Twelve discrete <li> elements at QRS lines 581–597.
9.4 Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. 🟢 The ER’s “— caution, glycaemic instability”, “— monitor, altered response”, “— caution, synergistic hormone release” trailing clauses are all stripped; no mechanism or mitigation text carried over.
9.5 Parenthetical qualifiers from the ER bullet — example drug lists, time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). 🟢 Every ER example-drug list is retained verbatim (prednisone/dexamethasone/hydrocortisone; glipizide/glimepiride/insulin itself; semaglutide/tirzepatide/liraglutide; risperidone/haloperidol/metoclopramide/amisulpride; sermorelin/tesamorelin/CJC-1295/ipamorelin/MK-677; levothyroxine/liothyronine; ibuprofen/naproxen; the three supplement lists).
9.6 When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. N/A The ER uses no ranking notation inside parentheses in its interaction entries.
9.7 If no [caution_items] are present the section is left empty N/A Caution items are present.

10. Protocol

# Description Result Comments
10.1 The section is derived from the ER Protocol section 🟢 Derived from ER Therapeutic Protocol lines 396–410 plus the mitigation parameters at lines 369–373.
10.2 The three sets of [action] items cover the three most important actionable implementation aspects from the ER Protocol section 🟢 Dose (100 µg subcutaneously), Frequency (2–3× daily), and Timing (empty stomach) are the three parameters the ER’s dominant pulsatile-secretagogue protocol is built on.
10.3 If less that three distinct actionable implementation aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. N/A Three distinct actionable aspects are present; no set is unused.
10.4 All used [action_#label], [action#value], [action#_sub] items are filled with meaningful content derived from the ER Protocol section. 🟢 All nine spans populated; subs carry the saturation rationale (ER line 396), the cycling pattern (line 396), and the fasted-state priority (lines 396, 404).

11. Time to Effect

# Description Result Comments
11.1 The three sets of [time] items cover the three most important time-to-effect aspects from the ER 🟢 Growth hormone pulse, appetite surge, and body composition — the three outcome-bearing timelines in ER line 451; the IGF-1 steady-state interval is folded into the third sub.
11.2 The sets are picked and ordered by the magnitude of the related benefit 🟢 Growth hormone pulse (High benefit) → appetite surge (Medium benefit) → body composition/lean mass (Low benefit), matching the ER’s benefit tiers at lines 153, 167, and 175.
11.3 If less that three distinct time-to-effect aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. N/A Three distinct time-to-effect aspects are present.
11.4 All used [time_#label], [time#value], [time#_sub] items are filled with meaningful content derived from the ER. 🟢 All nine spans populated; values 30–45 min, 20–30 min, and 8–12 weeks all appear in ER line 451.
11.5 If the ER does not provide any information on time to effect, the section is removed completely from the Protocol Panel N/A The ER provides an explicit “Time to effect” bullet at line 451.

12. Benefits

# Description Result Comments
12.1 The section is derived from the ER Expected Benefits section 🟢 All ten entries correspond to the ER benefit headings at lines 153–213.
12.2 Key variables are [benefits_high], [benefits_medium], [benefits_low], [benefits_speculative] 🟢 All four spans present and populated at QRS lines 531–547.
12.3 Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. 🟢 Each entry is the ER heading alone; the ER’s Magnitude paragraphs, p-values, confidence intervals, and single-institution caveats are entirely absent.
12.4 Parenthetical content — including effect sizes, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. 🟢 No parentheses occur in any benefits span.
12.5 If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. N/A All four ER benefit tiers contain items.

13. Risks

# Description Result Comments
13.1 The section is derived from the ER Potential Risks & Side Effects section 🟢 All eleven entries correspond to the ER risk headings at lines 237–303.
13.2 Key variables are [risks_high], [risks_medium], [risks_low], [risks_speculative] 🟢 All four spans present and populated at QRS lines 609–626.
13.3 Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. 🟢 Each entry is the ER heading alone; the ER’s Magnitude data (2.7 kg vs 0.8 kg, cortisol 56.0 ± 31.0 ng/mL) and mechanistic paragraphs are absent.
13.4 Parenthetical content — including frequencies, severity grades, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. 🟢 No parentheses occur in any risks span.
13.5 If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. N/A All four ER risk tiers contain items.

14. Monitoring

# Description Result Comments
14.1 The section is derived from the ER Monitoring section 🟢 Drawn from the ER Monitoring Protocol & Defining Success biomarker table at lines 479–489.
14.2 All measurable/quantifiable biomarkers from the Monitoring section are listed 🟢 All nine ER biomarkers present in ER order: IGF-1, IGF binding protein 3, fasting glucose, fasting insulin, hemoglobin A1c, morning cortisol, prolactin, TSH and free T4, apolipoprotein B — with targets and rationales carried verbatim.
14.3 [monitoring_cadence] is populated with the monitoring cadence/frequency derived from the ER Monitoring section. It is not left with placeholder text or empty. 🟢 Populated at QRS lines 758–761, condensing the ER’s baseline and ongoing-cadence paragraphs (lines 475–477) including the 2–3 week off-period retest.

15. Qualitative Assessment

# Description Result Comments
15.1 The section is derived from the ER Monitoring section 🟢 Drawn from the ER “Qualitative markers” list at lines 493–501.
15.2 All subjective/qualitative biomarkers from the Monitoring section are listed 🟢 All nine ER qualitative markers present and in ER order: hunger, sleep quality, morning puffiness/ankle swelling, hand numbness, joint aching, waist circumference, recovery quality, afternoon energy stability, libido and cycle regularity.

Issues 07/08/2026 08:47

Pass rate 100.00%. No issues found.