Made from unroasted coffee beans rich in plant antioxidants. The most consistent evidence shows small reductions in blood pressure and in fasting and after-meal blood sugar, greatest in people starting with elevated levels. Weight effects are small and conflicted; other benefits are less certain. Main downsides tie to caffeine in non-decaffeinated products. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Fasting blood glucose | 75–85 mg/dL | Primary metabolic target of the extract |
| Glycated hemoglobin (HbA1c) | <5.3% | Average blood sugar over ~3 months |
| Office blood pressure | <120/80 mmHg | Main cardiovascular endpoint with evidence |
| Total & LDL cholesterol | Total <180 mg/dL; LDL context-dependent | Tracks the modest lipid effect |
| Triglycerides | <80 mg/dL | Sensitive to carbohydrate handling |
| High-sensitivity C-reactive protein (hs-CRP) | <1.0 mg/L | Body-wide inflammation marker |
| ALT & AST (liver enzymes) | <25 U/L | Detects liver effects; relevant in fatty liver |
| Homocysteine | 6–8 µmol/L | Flags the theoretical chlorogenic-acid effect |
| Estimated glomerular filtration rate (eGFR) | >90 mL/min/1.73 m² | Kidney function, relevant if combining agents |
Cadence: Blood pressure at home weekly during the first month, then blood glucose, lipids, and other labs at about 8–12 weeks, and every 6–12 months thereafter if use continues.