A concentrated extract of the oat plant harvested green, a different material from breakfast oats. The most consistent finding is a small, task-specific gain in attention, working memory and juggling two tasks, appearing within hours of a single dose. Taking more has repeatedly worked less well than taking less. Side effects have been minor. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Timed cognitive battery score | Change from own two-session baseline | The only endpoint any human trial has actually moved |
| Brachial flow-mediated dilation | 7% or above | The arterial dilation this extract improved in trials |
| High-sensitivity C-reactive protein (hs-CRP) | Below 1.0 mg/L | Inflammatory tone the extract's polyphenols are proposed to lower |
| Homocysteine | 6–8 µmol/L | Links the vascular and cognitive risk this intervention targets |
| Glycated haemoglobin (HbA1c) | 4.9–5.3% | Glycaemic control shapes both arterial dilation and cognitive trajectory |
| Alanine aminotransferase (ALT) | 10–25 U/L (men), 10–20 U/L (women) | Baseline liver safety marker before any long-term botanical |
| Tissue transglutaminase immunoglobulin A antibody (tTG-IgA) | Negative, below the assay cut-off | Identifies celiac disease before repeated oat-derived exposure |
| Seated blood pressure | Recorded on three separate days at baseline | Catches any additive vasodilation while on antihypertensive drugs |
Cadence: Cognitive battery at 4 and 12 weeks; blood pressure weekly for the first month if taking antihypertensive drugs; blood panel at 6 months and annually thereafter.