Humanin is a small mitochondrial protein that helps keep cells alive under stress. Blood levels fall with age, and children of very long-lived people carry high levels. Laboratory and animal work suggests protection for nerve cells and metabolism, but one animal study found it may speed cancer growth, and no human trials confirm benefit or safety. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Fasting glucose | 75–90 mg/dL | Detects added glucose-lowering effect |
| Fasting insulin | 2–6 µIU/mL | Tracks insulin-sensitivity changes |
| HbA1c | <5.4% | Longer-term glucose control |
| hs-CRP | <1.0 mg/L | Systemic inflammation marker |
| CBC | Within normal limits | General safety/immune screen |
| Comprehensive metabolic panel | Within normal limits | Kidney/liver safety screen |
| Cancer screening (age-appropriate) | No active disease | Screens the key contraindication |
Cadence: Baseline, then at 4 weeks, 12 weeks, and every 3–6 months thereafter, with earlier review if any adverse change occurs.