Kaempferol for Health & Longevity - Quick Reference Sheet

Kaempferol for Health & Longevity

Created on 07/22/2026 – Quick Reference based on Evidence Review created using AI4L / Opus 4.8 Audit

A natural plant compound found in leafy greens, tea, and many vegetables, now also sold as a supplement. In lab and animal studies it calms inflammation, strengthens the body's own antioxidant defenses, and helps clear worn-out cells that build up with age. Human proof is lacking and absorption is poor, so benefits stay promising but unproven. (Full Review)

Protocol

Dose
50–100 mg daily
Standardized plant extract, once daily
Timing
With a fatty meal
Improves poor absorption
Absorption
Pair with piperine or quercetin
Phytosome or nano forms aid uptake
Time to effect
Anti-inflammatory
Weeks
Plausible; unproven in humans
Senolytic / longevity
No set timeline
No measurable short-term readout
In humans overall
Unknown
Expectations should be modest

Benefits

Contraindications
  • Pregnancy and breastfeeding
  • Hormone-sensitive cancers
  • Significant thyroid disease
  • Bleeding disorders or surgery within ~2 weeks
Key Interactions
  • Narrow-therapeutic-index CYP3A4 drugs (statins, calcium-channel blockers, cyclosporine)
  • Anticoagulants and antiplatelets (warfarin, clopidogrel, aspirin)
  • P-glycoprotein substrate drugs (digoxin)
  • OTC medications (NSAIDs, antacids)
  • Additive supplements (quercetin, fisetin, resveratrol, ginkgo, fish oil)
  • Blood-sugar-lowering drugs (metformin, sulfonylureas, berberine)

Risk & Side Effects

  • Low: Gastrointestinal discomfort at high doses
  • Speculative: Drug-metabolism & transporter interactions; hormonal modulation; thyroid peroxidase inhibition; pro-oxidant effects

Monitoring

Marker Target Why
hs-CRP < 1.0 mg/L Tracks whether an anti-inflammatory effect is occurring
Fasting glucose 75–90 mg/dL Screens for metabolic/glycemic effect and additive glucose lowering
HbA1c < 5.4% Longer-term blood-sugar control
Lipid panel HDL-C > 50 mg/dL; triglycerides < 100 mg/dL Follows the proposed cardiometabolic benefit
TSH 0.5–2.5 mIU/L Guards against the theoretical thyroid-enzyme concern at high doses
ALT / AST < 25 U/L (women) / < 30 U/L (men) General safety check of liver processing

Cadence: Baseline before starting, recheck at ~3 months, then every 6–12 months

Qualitative Assessment

  • Energy and physical stamina
  • Cognitive clarity
  • Joint comfort
  • Sleep quality and recovery
  • Digestive tolerance