Kambô, a waxy skin secretion from an Amazonian tree frog applied to small skin burns, is sought for mood, recovery from addiction and pain relief. It triggers a brief, violent bout of vomiting, racing heart and swelling. Reported gains come only from user surveys with no comparison group, while dangerous drops in blood sodium, seizures, liver and kidney injury and sudden deaths are reported, how often unknown. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Serum sodium | 135–145 mmol/L | Safety check: low sodium stops use |
| Creatinine / eGFR | Creatinine about 0.6–1.3 mg/dL | Safety check: kidney injury stops use |
| ALT | About 7–55 U/L | Safety check: liver injury stops use |
| Creatine kinase (CK) | About 26–308 U/L, varying by sex and laboratory | Safety check: muscle breakdown stops use |
| Resting ECG | No established target; compare with own baseline | Safety check: hidden heart disease stops use |
| Blood pressure | No established target; track change from own baseline | Safety check: low pressure stops use |
| Pregnancy test (hCG) | Negative | Safety check: pregnancy stops use |
Cadence: Baseline before a first session; event-driven rather than calendar-driven: sodium, creatinine, ALT and CK rechecked within 24–72 hours after any session followed by prolonged vomiting, confusion, muscle pain, dark urine or yellowing skin; baseline panel repeated before each new series, or every 6–12 months for regular users