Audit: QRS - Kanna for Health & Longevity

Audit conducted on 16/08/2026 21:32 using AI4L / Opus 5

Iterations

Summary

Items Count
Total 93
Passed 85
Failed 0
N/A 8
Pass Rate 100.00%
  • Total = Passed + Failed + N/A
  • Pass Rate = Passed / (Passed + Failed) × 100
  • N/A items are excluded from the pass rate calculation

1. General Rules

# Description Result Comments
1.1 Every claim, magnitude, label, recommendation, and statement in the QRS is literally supported by content in the source ER. 🟢 Every populated span traces to ER text: protocol cells to ER Therapeutic Protocol, time cells to ER Practical Considerations “Time to effect”, benefit/risk tiers to ER sub-headings, gates to ER Key Interactions & Contraindications, monitoring rows and cadence to the ER biomarker table, qualitative items verbatim from ER lines 428-433.
1.2 Where the ER uses cautious phrasing (“not formally studied”, “None documented in human trials to date”, “theoretical concern”, “data are limited”), the QRS uses the same phrasing. 🟢 No cautious ER phrasing is reworded; the QRS carries ER wording such as “the dose used in every positive human trial” and “the one trial that recorded it” unchanged.
1.3 The QRS never strengthens an ER claim (e.g., “not formally studied” → “not required”) or softens one (e.g., “do not use during pregnancy” → “use with caution during pregnancy”). 🟢 Avoidance populations stay in the STOP gate at full strength (MAOI, SSRI/SNRI, pregnancy, under-18, bipolar, PHQ-9 >9, uncontrolled hypertension); caution-level interactions stay in the caution gate.
1.4 The QRS does not relabel an ER fact under a different decision category. A “Benefit-Modifying Factor” from ER section is not surfaced as a “Caution”; a “Risk-Modifying Factor” is not surfaced as a “Side Effect”; etc. 🟢 No content from ER Benefit-Modifying Factors or Risk-Modifying Factors appears in the gates or risk card; each QRS block draws only from its mapped ER section.
1.5 PubMed IDs, study citations, expert names, clinical trial identifiers (NCT*), and brand names appear in the QRS only if they appear in the source ER for the same fact. 🟢 The QRS contains no PMIDs, author names, NCT identifiers, or brand names; ER brand examples (Robitussin DM, Delsym, Zembrin) were dropped rather than introduced.
1.6 The QRS does not introduce new attributions. 🟢 No attributions of any kind appear outside the fixed template header line.

2. Focus, Tone & Audience

# Description Result Comments
2.1 The QRS follows the tone of the ER, which is determined by the ER’s own language, phrasing, and framing. 🟢 Measured, evidence-first register matching the ER; the at-a-glance mirrors the ER Conclusion framing of a narrow, thin evidence base.
2.2 The tone of the QRS is simultaneously expert, accessible, objective, and data-driven, but also empowering and encouraging 🟢 Quantified targets and doses are paired with plain-language rationale in every sub-line.
2.3 The QRS reads as a trusted, knowledgeable guide rather than a prescriptive doctor 🟢 Content is stated as observed evidence (“the design under which the anxiety effects were demonstrated”), not as instruction to a patient.
2.4 The QRS avoids language that implies medical or clinical advice 🟢 No imperatives directed at a reader; monitoring targets are presented as functional ranges carried from the ER table.
2.5 The QRS “presents information” instead of “providing guidance”, “recommending”, or “advising” 🟢 No occurrence of “recommended”, “advised”, “should take”, or equivalent in the QRS’s own voice.
2.6 The QRS never addresses “the reader” directly — it presents evidence, not guidance 🟢 No second-person pronouns anywhere in the document body.
2.7 The QRS is written in plain language, avoiding unnecessary medical jargon 🟢 Technical terms are limited to necessary marker and drug-class names carried from the ER; the at-a-glance uses “brain messenger system” rather than transporter terminology.
2.8 Information is presented in a concise and very compact manner 🟢 Every list item is a single condensed clause; benefit and risk tiers are semicolon-joined heading distillations.
2.9 It DOES NOT address the reader directly 🟢 Confirmed: no “you”/”your” in the rendered content.
2.10 The target audience is health- and longevity-oriented adults who are risk-aware, proactive, and actively seeking to optimize health or apply the intervention under review. 🟢 Content assumes willingness to run bloodwork, track a weekly anxiety score, and verify a certificate-of-analysis-grade product.
2.11 The target audience is willing to employ lifestyle and behavioral changes as well as follow protocols that may be inconvenient, costly, or require effort. 🟢 Eight-marker monitoring panel and staged cadence assume a high-effort implementer.
2.12 The document is NOT written for the general population, who are unwilling to employ lifestyle and behavioral changes or follow protocols that may be inconvenient, costly, or require effort. 🟢 No simplified consumer framing; the sheet presumes lab access and self-quantification.
2.13 Framing, takeaways, and risk/benefit weighting throughout the document reflect this audience, including where an intervention’s signal for the average person differs from its signal for this audience. 🟢 The at-a-glance foregrounds the two decision-relevant hazards (antidepressant stacking, product variability) and explicitly denies a broad mood lift.
2.14 The document’s own voice frames usage in longevity terms, not “anti-aging” (e.g., “anti-aging clinics”, “anti-aging community”, “anti-aging medicine”). Proper names that contain “anti-aging” (e.g., “American Academy of Anti-Aging Medicine”) are quoted verbatim. 🟢 No occurrence of “anti-aging”; the header carries the ER canonical topic “Kanna for Health & Longevity”.
2.15 The document’s own voice uses formal clinical and scientific terminology, not colloquial or consumer-grade language (e.g., “oral medication” not “pill(s)”; “injection” not “shot”; “adverse event” not “bad reaction”). Direct quotes from sources are exempt. 🟢 Formal register throughout (“treatment-emergent adverse effects”, “motor incoordination”, “serotonergic”); the few plain terms are carried verbatim from the ER.

3. Template Integrity

# Description Result Comments
3.1 The following labels and headings on the QRS are fixed and not modified: Card and section headings: “Protocol”, “Time to effect”, “Benefits”, “Risk & Side Effects”, “Monitoring”, “Qualitative Assessment”; Gate headings: “Contraindications”, “Key Interactions”; Tier labels: “High”, “Medium”, “Low”, “Speculative”; Table column headers in Monitoring: “Marker”, “Target”, “Why” 🟢 All fixed headings, gate headings, tier labels, and the Marker/Target/Why column headers match the template byte for byte.
3.2 All “” from the [qrs_template] are present in the the QRS. 🟢 All 34 template variables are present; the repeatable marker_#_* and qualitative_item_# spans are expanded to marker_1-marker_8 and qualitative_item_1-qualitative_item_6.
3.3 Spans that are not addressed in a checklist item are left unchanged 🟢 The non-variable spans website="evidence_review", website="audit", and website="full_review" are unchanged; a structural diff against the template shows no edits outside variable content.

4. Formatting

# Description Result Comments
4.1 When the source ER section is empty, the QRS uses the ER’s own empty-state phrasing verbatim. Typical phrasings are “None documented in human trials to date” and “Not formally studied” N/A No ER section mapped to a QRS variable is empty; the two absent tiers (High benefit, High risk) are governed by items 12.5 and 13.5, which mandate hiding rather than empty-state phrasing.
4.2 Where the ER presents a bulleted item as “Label: content”, the QRS uses the ER’s bold label verbatim as the cell or row label. 🟢 “Standard daily protocol”, “Acute situational protocol”, and “Time of day” are the ER’s bold protocol labels verbatim; monitoring row labels match the ER Biomarker column verbatim.
4.3 Labels are not paraphrased, abbreviated, or invented. 🟢 Protocol and marker labels are verbatim; the three time-to-effect cell labels derive directly from the ER benefit headings they index, since the ER supplies no per-aspect bold label.
4.4 The QRS DOES NOT use emoji indicators (no 🟩, 🟥, 🟨, etc.). Color and emphasis are conveyed through CSS and bold labels. 🟢 No emoji codepoints anywhere in the file; the ER’s ⚠️ Conflicted markers and tier squares were stripped.
4.5 The QRS is designed to render on one A4 page. Any section that has more content in the ER than fits the per-section budget is condensed by the LLM, not extended onto a second page. 🟢 Every section is condensed to single-clause items; the at-a-glance is 56 words and no ER section was carried at full length.

5. Metadata

# Description Result Comments
5.1 The metadata is placed inside a single HTML comment that is the first element after “<!doctype html>” and before any other comment, head, or body content. 🟢 The comment opens on line 2, immediately after <!doctype html> on line 1, and closes on line 14 before any other markup.
5.2 Inside that HTML comment the YAML block is delimited by a line “—” opening and a line “—” closing. Text before the opening “—” is permitted but is not parsed as YAML. 🟢 Opening --- on line 3, closing --- on line 13; the preceding descriptive line sits outside the block.
5.3 The metadata is not visible in any rendered view of the QRS and is not surfaced by any other element on the sheet. 🟢 Contained entirely within the HTML comment; no metadata value is repeated in the header, footer, or any span.
5.4 All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. 🟢 Only duration: "00:03" is quoted, correctly so because it contains a colon; all other values are bare and trimmed.
5.5 The filename of the source ER is stated as “er_filename: [er_filename]” 🟢 Line 4: er_filename: kanna_2026-0825-1904_Opus_ER.md, matching the ER’s own filename frontmatter value.
5.6 Version of the QRS.md file used to create the document is stated as “qrs_prompt_version: [Version of QRS.md]” 🟢 Line 5: qrs_prompt_version: 26.7.02, matching the version badge at the top of QRS.md.
5.7 Creation date and time of the document is stated as “qrs_creation_date: [YYYY-MMDD-HHMM]” (e.g., 2026-0501-1430) 🟢 Line 6: qrs_creation_date: 2026-0816-2120, correctly formatted.
5.8 The nickname of the AI used to create the document is stated as “qrs_creator_ai_nickname: [qrs_creator_ai_nickname]” 🟢 Line 7: qrs_creator_ai_nickname: Opus.
5.9 The nickname of the AI is just a single word model name without version, etc. (e.g., Opus, Sonnet, Grok, Gemini, ChatGPT) 🟢 “Opus” is a single word with no version or qualifier.
5.10 The full name of the AI used to create the document is stated as “qrs_creator_ai_fullname: [qrs_creator_ai_fullname]” 🟢 Line 8: qrs_creator_ai_fullname: Opus 5.
5.11 The full name of the AI consists of the [qrs_creator_ai_nickname] and the model version number and no additional qualifier (e.g., Opus 4.6, Sonnet 3.2, Grok 4.5, Gemini 3.1, ChatGPT 5.4) 🟢 “Opus 5” is nickname plus version with no context-window or tier qualifier appended.
5.12 The filename of the document is stated as “qrs_filename: [filename of this document]” 🟢 Line 9: qrs_filename: kanna_2026-0825-1904_Opus_QRS.html, matching the file on disk.
5.13 All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. 🟢 Re-verified across all nine keys including git_user and git_issue; no stray whitespace or unnecessary quoting.

6. Page Title & Header

# Description Result Comments
6.1 [page_title] is set to the [canonical_topic] of the ER frontmatter followed by “ - Quick Reference Sheet” (e.g., “Intervention - Quick Reference Sheet”). The [canonical_topic] is HTML-entity-encoded as needed (e.g., &amp; for &) 🟢 Line 22: Kanna for Health &amp; Longevity - Quick Reference Sheet, with the ampersand correctly entity-encoded.
6.2 [header_topic] is set to the [canonical_topic] of the ER frontmatter, with HTML entities encoded as needed (e.g., &amp; for &) 🟢 Line 417: Kanna for Health &amp; Longevity, matching the ER canonical_topic.
6.3 [header_subline_date] is set to [qrs_creation_date reformatted as MM/DD/YYYY] 🟢 Line 421: 08/16/2026, the correct reformatting of 2026-0816-2120.
6.4 [header_subline_model] is set to [qrs_creator_ai_fullname] 🟢 Line 425: Opus 5, matching the qrs_creator_ai_fullname frontmatter value.
6.5 No additional header content appears: no badge, version stamp, AKA / alternate names line, source-AI attribution, audit date, or QRS variant marker. 🟢 The header holds only the title and the template subline; the ER’s alternate_names list was not carried over.

7. At-A-Glance Section

# Description Result Comments
7.1 [at_a_glance] is dense, execution-oriented summary of the ER Conclusion section 🟢 Condenses the ER Conclusion into mechanism, the three measured effects, the explicit null, and the two decision-relevant hazards.
7.2 [at_a_glance] is no longer than 60 words 🟢 56 words.
7.3 Every fact in [at_a_glance] is supported by a distinct passage in the ER. 🟢 Each clause maps to a distinct sentence of the ER Conclusion (ER lines 455-457).
7.4 It DOES NOT use acronyms or technical classifications that require specialist knowledge, uses plain-language terms instead 🟢 No acronyms; “brain messenger system” replaces serotonin-transporter terminology and “prescribed antidepressants” replaces the SSRI/SNRI class names.
7.5 It DOES NOT cite specific trials (names, years, sample sizes, p-values) 🟢 Only the generic phrase “small trials in healthy volunteers” appears; no author, year, or sample size.
7.6 It DOES NOT cite effect sizes, relative risks, or statistical results 🟢 No η², Cohen’s d, p-value, or percentage appears.

8. Contraindications

# Description Result Comments
8.1 The section is derived from the ER Key Interactions & Contraindications section 🟢 All seven items come from the ER “Populations who should avoid Kanna” list at ER lines 296-302.
8.2 [stop_items] represent the Contraindications from the ER 🟢 All seven ER avoidance populations are represented, one-for-one, with none added or omitted.
8.3 Individual [stop_items] are formatted as <li></li> 🟢 Seven discrete <li> elements inside the stop_items span (lines 571-577).
8.4 Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. 🟢 Every ER em-dash rationale is stripped: “no safety or efficacy data exist”, “no trial has enrolled anyone below 18”, “serotonergic agents can precipitate mania”, and “the exclusion threshold used in the current recruiting trial” are all absent.
8.5 Parenthetical qualifiers from the ER bullet — time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). 🟢 The 14-day MAOI washout, the “under 18” age bound, the PHQ-9 “>9 or any suicidality item above 0” thresholds, and “(above 160/100 mmHg)” are all retained.
8.6 When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. N/A The ER uses no ranking notation inside parentheses anywhere in Key Interactions & Contraindications.
8.7 The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no population, condition, or scenario for which the intervention should be avoided, deferred, or used only under specialist supervision. 🟢 The ER names seven avoidance populations, and the section is correspondingly populated rather than empty.
8.8 If the section is left empty, an HTML comment inside the [stop_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. N/A The section is not empty.

9. Key Interactions

# Description Result Comments
9.1 The section is derived from the ER Key Interactions & Contraindications section 🟢 All eight items come from the ER interaction bullets at ER lines 278-292.
9.2 [caution_items] represent the Key Interactions from the ER, excluding any that are already listed as Contraindications 🟢 The eight non-contraindicated ER interactions are carried; the SSRI, SNRI, and MAOI bullets are correctly excluded because they appear in the STOP gate.
9.3 Individual [caution_items] are formatted as <li></li> 🟢 Eight discrete <li> elements inside the caution_items span (lines 585-597).
9.4 Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. 🟢 All ER “Caution; …” rationales and “Mitigation: …” clauses are stripped; each item is the bare agent or class name plus its example list.
9.5 Parenthetical qualifiers from the ER bullet — example drug lists, time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). 🟢 Every ER example list is preserved and trimmed only where permitted: “(tramadol, triptans, linezolid, lithium)”, “(cough syrups)”, “(diphenhydramine, doxylamine)”, “(5-hydroxytryptophan, L-Tryptophan, St. John’s wort, S-adenosylmethionine)”, “(ashwagandha, L-Theanine, kava, valerian)”, “(roflumilast, apremilast)”.
9.6 When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. N/A The ER uses no ranking notation inside parentheses in this section.
9.7 The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no interaction, additive effect, or exposure that changes how the intervention is used. 🟢 The ER names eleven interactions, and the section is correspondingly populated rather than empty.
9.8 If the section is left empty, an HTML comment inside the [caution_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. N/A The section is not empty.

10. Protocol

# Description Result Comments
10.1 The section is derived from the ER Protocol section 🟢 All three action cells trace to ER Therapeutic Protocol bullets at ER lines 326, 330, and 338.
10.2 The three sets of [action] items cover the three most important actionable implementation aspects from the ER Protocol section 🟢 Standard daily dose, acute situational dose, and time of day are the three decision-bearing implementation aspects; the remaining ER bullets are informational (half-life, genetics, sex, age) or explicitly untested.
10.3 If less that three distinct actionable implementation aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. N/A The ER supplies well over three actionable aspects; all three sets are populated.
10.4 All used [action_#label], [action#value], [action#_sub] items are filled with meaningful content derived from the ER Protocol section. 🟢 All nine spans carry ER-derived content; no placeholder or empty value remains.

11. Time to Effect

# Description Result Comments
11.1 The three sets of [time] items cover the three most important time-to-effect aspects from the ER 🟢 The ER’s “Time to effect” bullet (ER line 385) names exactly three intervals — within 60 minutes, three weeks, and eight days — and all three are carried.
11.2 The sets are picked and ordered by the magnitude of the related benefit 🟢 Ordered situational anxiety, cognitive flexibility, complex reaction, matching the ER Expected Benefits ordering and the descending strength of the reported magnitudes.
11.3 If less that three distinct time-to-effect aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. N/A The ER supplies exactly three time-to-effect aspects; all three sets are populated.
11.4 All used [time_#label], [time#value], [time#_sub] items are filled with meaningful content derived from the ER. 🟢 All nine spans carry ER-derived content; the sub-lines paraphrase ER line 385 without adding facts.
11.5 If the ER does not provide any information on time to effect, the section is removed completely from the Protocol Panel N/A The ER provides explicit time-to-effect information, so the section is correctly retained.

12. Benefits

# Description Result Comments
12.1 The section is derived from the ER Expected Benefits section 🟢 Every listed item corresponds to an ER Expected Benefits sub-heading.
12.2 Key variables are [benefits_high], [benefits_medium], [benefits_low], [benefits_speculative] 🟢 All four spans are present at lines 541, 544, 550, and 556.
12.3 Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. 🟢 Each tier is a semicolon-joined list of bare ER headings; no p-values, Cohen’s d, η², sample sizes, or PDE4 mechanism text is carried.
12.4 Parenthetical content — including effect sizes, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. 🟢 No parentheses appear in any benefits span.
12.5 If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. 🟢 The ER states “No benefit of kanna currently reaches this evidence level” for High, and benefits_high carries style="display: none" with no empty-state text (line 541).

13. Risks

# Description Result Comments
13.1 The section is derived from the ER Potential Risks & Side Effects section 🟢 Every listed item corresponds to an ER Potential Risks & Side Effects sub-heading.
13.2 Key variables are [risks_high], [risks_medium], [risks_low], [risks_speculative] 🟢 All four spans are present at lines 609, 612, 618, and 624.
13.3 Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. 🟢 Each tier is a semicolon-joined list of bare ER headings; the 14% weight-gain incidence, 39-fold hordenine range, and CYP17 mechanism are all omitted.
13.4 Parenthetical content — including frequencies, severity grades, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. 🟢 No parentheses appear in any risks span; the ER’s “(loss of coordinated movement)” gloss is stripped.
13.5 If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. 🟢 The ER states “No risk of kanna reaches this evidence level” for High, and risks_high carries style="display: none" with no empty-state text (line 609).

14. Monitoring

# Description Result Comments
14.1 The section is derived from the ER Monitoring section 🟢 All rows come from the biomarker table in ER Monitoring Protocol & Defining Success (ER lines 415-424).
14.2 All measurable/quantifiable biomarkers from the Monitoring section are listed 🟢 All eight ER biomarkers are present: seated blood pressure, resting heart rate, serum sodium, ALT, AST, morning cortisol, GAD-7 anxiety score, and sleep-onset latency, with targets carried verbatim.
14.3 [monitoring_cadence] is populated with the monitoring cadence/frequency derived from the ER Monitoring section. It is not left with placeholder text or empty. 🟢 Lines 753-757 carry the full ER cadence from ER line 413: weekly anxiety score for the first month, blood pressure and heart rate at four weeks, sodium and liver enzymes at three months and then six to twelve months.

15. Qualitative Assessment

# Description Result Comments
15.1 The section is derived from the ER Monitoring section 🟢 All six items come from the qualitative markers list in ER Monitoring Protocol & Defining Success (ER lines 428-433).
15.2 All subjective/qualitative biomarkers from the Monitoring section are listed 🟢 All six ER qualitative markers are present and carried verbatim: subjective calm, task-switching ease, reaction quality, sleep onset and grogginess, appetite direction, and absence of serotonergic excess signs.

Issues 16/08/2026 21:32

Pass rate 100.00%. No issues found.

Issues 16/08/2026 21:26

  1. 12.3 — Trailing elaboration in Benefits Low: The benefits_low item at line 552 of the QRS reads “appetite and thirst suppression — not supported by the trial data”; the clause after the em-dash is an elaboration/qualifier that the Low tier already encodes and must be stripped.

Fixes 16/08/2026 21:26

  1. 12.3 — Trailing elaboration in Benefits Low: Stripped the em-dash clause from the benefits_low item, changing “appetite and thirst suppression — not supported by the trial data” to “appetite and thirst suppression”.