A marine oil that dependably raises omega-3 fats in cell membranes, a measure that tracks with longer survival, and improves blood fats when those start high. Muscle strength gains after 65 rest on one study; joint and inflammation claims are contested. Shellfish allergy is an absolute barrier; irregular heartbeat risk rises with dose. Costs several times more than fish oil. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Omega-3 Index | 8–12% of red blood cell fatty acids | The one marker krill oil reliably moves; anchors dosing |
| Triglycerides (fasting) | < 80 mg/dL (< 0.9 mmol/L) | Primary lipid target; predicts who responds |
| Apolipoprotein B | < 80 mg/dL, or < 60 mg/dL at high cardiovascular risk | Counts atherogenic particles better than LDL-C when triglycerides are high |
| High-sensitivity C-reactive protein | < 0.5 mg/L | Tracks the contested inflammation claim |
| Arachidonic acid to EPA ratio | 3:1 to 8:1 | Shows the membrane shift away from pro-inflammatory precursors |
| Resting pulse rhythm | Regular rhythm; no numeric target exists | Detects the dose-dependent atrial fibrillation signal early |
Cadence: Baseline panel before starting, then the Omega-3 Index and lipids at 4 months, again at 12 months, then every 12 months while supplementation continues.