Livagen for Health & Longevity - Quick Reference Sheet

Livagen for Health & Longevity

Created on 09/01/2026 – Quick Reference based on Evidence Review created using AI4L / Opus 5 Audit

A four-unit peptide built in Russia from a liver extract, proposed to loosen the packed genetic material of ageing cells. Measured only in cells from older donors and in old rats, never as a health outcome in a living person. Risks are unmeasured, not absent. Supply runs entirely through unregulated sellers. An unresolved question, not a supported choice. (Full Review)

Protocol

Cyclical short-course approach
10–20 day course, 2–3× yearly
Rather than continuous daily use.
Oral route
1–2 capsules daily, 10–30 days
On an empty stomach; Livagen resists intestinal breakdown.
Injected route
1–2 mg subcutaneous daily, 10–20 days
Research-vendor material supplied as 20 mg freeze-dried vials.
Time to effect
Time to effect in humans
Unknown
No human study has measured any outcome on any timescale.
Cell and animal work
1–14 days of exposure
Offers no basis for predicting a perceptible human effect.

Benefits

Contraindications
  • Active malignancy, or within 5 years of a solid-tumour or blood cancer diagnosis
  • Decompensated liver disease (Child-Pugh Class B or C)
  • Chronic kidney disease stage 4 or worse (filtration rate below 30 mL/min/1.73 m²)
  • Solid organ transplant recipients on maintenance immunosuppression
  • Pregnant or breastfeeding women
  • Anyone under 18 years of age
  • Known allergy to injected peptides or to benzyl alcohol preservatives
  • Unable to obtain product with third-party identity, purity and sterility documentation
Key Interactions
  • Opioid analgesics and opioid antagonists (morphine, oxycodone, buprenorphine, naltrexone)
  • Dipeptidyl peptidase-4 inhibitors (sitagliptin, linagliptin, saxagliptin)
  • Immunosuppressants (tacrolimus, ciclosporin, mycophenolate, prednisone)
  • Acetaminophen and high-dose non-steroidal anti-inflammatory painkillers (ibuprofen, naproxen)
  • Other short peptide bioregulators (Epitalon, Vilon, Cortagen)
  • Liver-support agents (milk thistle silymarin, N-acetylcysteine, tauroursodeoxycholic acid)
  • Heavy metal exposure and metal-containing preparations

Risk & Side Effects

  • Low: Harm from Unregulated, Unverified Product
  • Speculative: Uncontrolled Switching-On of Silenced Genes; Increased Sister Chromatid Exchange in Telomeric Regions; Reduced Digestive Enzyme Activity in Younger Users; Interference with Endogenous Opioid Signalling; Immune Reaction and Injection-Site Reactions

Monitoring

Marker Target Why
ALT 10–26 U/L men, 10–19 U/L women Detects liver cell injury, the target organ
AST 10–26 U/L Confirms whether an enzyme rise is liver or muscle
GGT Below 20 U/L men, below 15 U/L women Most sensitive early marker of liver stress and bile flow
ALP 60–90 U/L Flags bile duct obstruction and bone turnover
Total bilirubin 0.4–1.0 mg/dL Reflects overall liver clearance capacity
Albumin 4.2–5.0 g/dL Reflects the liver's synthetic capacity, the function Livagen targets
hs-CRP Below 0.5 mg/L Tracks the inflammatory status the animal work claims is normalised
Complete blood count with differential Lymphocytes 1.5–3.0 ×10⁹/L, neutrophils 2.0–4.0 ×10⁹/L Detects marrow effects no trial has excluded, and tracks the claimed immune effect
Ferritin 50–100 ng/mL men, 30–80 ng/mL women Iron overload is a common confounder of raised liver enzymes
Epigenetic age acceleration No established target exists for this measure; track the change from the individual's own baseline instead It is the outcome the proposed mechanism most directly predicts

Cadence: Baseline before starting; liver panel and blood count 2 to 4 weeks after a course ends, then at 3 months, then every 6 to 12 months if courses continue. Inflammatory markers and iron stores follow the 3-month and annual timepoints; epigenetic age is interpretable only at 6 to 12-month intervals.

Qualitative Assessment

  • Digestive comfort and tolerance of fat-rich or protein-rich meals
  • Energy through the day, and whether any change tracks the course or its cessation
  • Sleep continuity and morning alertness
  • Cognitive clarity and sustained attention
  • Injection-site appearance, and any rash, itch or fever
  • Exercise recovery and perceived training capacity