Audit: QRS - Manuka Honey for Health & Longevity

Audit conducted on 04/09/2026 01:45 using AI4L / Opus 5

Iterations

Summary

Items	Count
Total	93
Passed	81
Failed	0
N/A	12
Pass Rate	100.00%

• Total = Passed + Failed + N/A
• Pass Rate = Passed / (Passed + Failed) × 100
• N/A items are excluded from the pass rate calculation

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1. General Rules

#	Description	Result	Comments
1.1	Every claim, magnitude, label, recommendation, and statement in the QRS is literally supported by content in the source ER.	🟢	Every populated span traces to ER text: protocol cells to ER Therapeutic Protocol lines 390/392/400, time cells to Practical Considerations line 456, benefit and risk tiers to the ER subsection headings, gates to Key Interactions & Contraindications, monitoring rows to the ER biomarker table.
1.2	Where the ER uses cautious phrasing (“not formally studied”, “None documented in human trials to date”, “theoretical concern”, “data are limited”), the QRS uses the same phrasing.	🟢	No ER section is empty and no cautious empty-state phrasing exists in the ER that the QRS needed to carry over.
1.3	The QRS never strengthens an ER claim (e.g., “not formally studied” → “not required”) or softens one (e.g., “do not use during pregnancy” → “use with caution during pregnancy”).	🟢	Contraindication scope is preserved (gamma-irradiated medical-grade honey only; no therapeutic oral dosing above HbA1c 8%); tier assignments match the ER exactly.
1.4	The QRS does not relabel an ER fact under a different decision category. A “Benefit-Modifying Factor” from ER section is not surfaced as a “Caution”; a “Risk-Modifying Factor” is not surfaced as a “Side Effect”; etc.	🟢	Gates draw only from Key Interactions & Contraindications; benefits from Expected Benefits; risks from Potential Risks & Side Effects. No Benefit- or Risk-Modifying Factor content appears anywhere on the sheet.
1.5	PubMed IDs, study citations, expert names, clinical trial identifiers (NCT*), and brand names appear in the QRS only if they appear in the source ER for the same fact.	🟢	No PMIDs, NCT identifiers, author names or brand names appear anywhere in the QRS.
1.6	The QRS does not introduce new attributions.	🟢	No attributions of any kind are present.

2. Focus, Tone & Audience

#	Description	Result	Comments
2.1	The QRS follows the tone of the ER, which is determined by the ER’s own language, phrasing, and framing.	🟢	The At-A-Glance mirrors the ER Conclusion’s topical-versus-oral split and its funding caveat; card items reuse the ER’s own headings.
2.2	The tone of the QRS is simultaneously expert, accessible, objective, and data-driven, but also empowering and encouraging	🟢	Sheet presents graded benefits, graded risks, concrete protocol figures and biomarker targets, enabling a decision without advocacy.
2.3	The QRS reads as a trusted, knowledgeable guide rather than a prescriptive doctor	🟢	Gate items are noun-phrase decision gates, not directives.
2.4	The QRS avoids language that implies medical or clinical advice	🟢	No imperative or advisory constructions; contraindications are stated as conditions, not instructions to the reader.
2.5	The QRS “presents information” instead of “providing guidance”, “recommending”, or “advising”	🟢	No recommending or advising verbs anywhere in the document.
2.6	The QRS never addresses “the reader” directly — it presents evidence, not guidance	🟢	No second-person pronouns present (verified across the whole file).
2.7	The QRS is written in plain language, avoiding unnecessary medical jargon	🟢	Plain terms are used where the ER supplies them (“eyelid oil-gland dysfunction”, “bacteria-killing compound”); remaining technical terms are load-bearing biomarker and drug-class names.
2.8	Information is presented in a concise and very compact manner	🟢	Every card item is a single terse phrase; benefit and risk tiers are semicolon-joined one-liners; monitoring “why” cells are 4–6 words.
2.9	It DOES NOT address the reader directly	🟢	Confirmed; no direct address anywhere in the file.
2.10	The target audience is health- and longevity-oriented adults who are risk-aware, proactive, and actively seeking to optimize health or apply the intervention under review.	🟢	Content assumes willingness to test biomarkers, source certified UMF product and follow dressing schedules.
2.11	The target audience is willing to employ lifestyle and behavioral changes as well as follow protocols that may be inconvenient, costly, or require effort.	🟢	Protocol cells specify UMF grading, neat oral dosing held in the mouth, and 1–3 day dressing changes without softening the effort involved.
2.12	The document is NOT written for the general population, who are unwilling to employ lifestyle and behavioral changes or follow protocols that may be inconvenient, costly, or require effort.	🟢	Nine-row biomarker panel with functional (not conventional) ranges is aimed squarely at the optimizing reader.
2.13	Framing, takeaways, and risk/benefit weighting throughout the document reflect this audience, including where an intervention’s signal for the average person differs from its signal for this audience.	🟢	At-A-Glance flags the topical/oral divergence and the commercial funding bias — the two facts that change the decision for this audience.
2.14	The document’s own voice frames usage in longevity terms, not “anti-aging” (e.g., “anti-aging clinics”, “anti-aging community”, “anti-aging medicine”). Proper names that contain “anti-aging” (e.g., “American Academy of Anti-Aging Medicine”) are quoted verbatim.	🟢	The string “anti-aging” does not occur; the title uses “Health & Longevity”.
2.15	The document’s own voice uses formal clinical and scientific terminology, not colloquial or consumer-grade language (e.g., “oral medication” not “pill(s)”; “injection” not “shot”; “adverse event” not “bad reaction”). Direct quotes from sources are exempt.	🟢	Card and gate content is clinical throughout; the plainer At-A-Glance register is required by item 7.4 and drawn from the ER Conclusion.

3. Template Integrity

#	Description	Result	Comments
3.1	The following labels and headings on the QRS are fixed and not modified: Card and section headings: “Protocol”, “Time to effect”, “Benefits”, “Risk & Side Effects”, “Monitoring”, “Qualitative Assessment”; Gate headings: “Contraindications”, “Key Interactions”; Tier labels: “High”, “Medium”, “Low”, “Speculative”; Table column headers in Monitoring: “Marker”, “Target”, “Why”	🟢	All fixed headings match the template byte-for-byte (lines 445, 488, 530, 562, 582, 605, 634, 638–640, 763).
3.2	All “…” from the [qrs_template] are present in the the QRS.	🟢	All 34 template variable names are present and in template order; marker_# and qualitative_item_# rows are correctly instantiated 9× and 6×.
3.3	Spans that are not addressed in a checklist item are left unchanged	🟢	The website="evidence_review", website="audit" and website="full_review" spans, the footer disclaimer, the stylesheet link and all CSS are byte-identical to the template.

4. Formatting

#	Description	Result	Comments
4.1	When the source ER section is empty, the QRS uses the ER’s own empty-state phrasing verbatim. Typical phrasings are “None documented in human trials to date” and “Not formally studied”	N/A	No source ER section mapped onto the QRS is empty.
4.2	Where the ER presents a bulleted item as “Label: content”, the QRS uses the ER’s bold label verbatim as the cell or row label.	🟢	action_1_label “Standard oral protocol”, action_2_label “Standard topical wound protocol” and action_3_label “Best time of day” are the ER’s bold labels verbatim (ER lines 390, 392, 400).
4.3	Labels are not paraphrased, abbreviated, or invented.	🟢	All nine monitoring marker_#_name values match the ER biomarker table’s first column verbatim.
4.4	The QRS DOES NOT use emoji indicators (no 🟩, 🟥, 🟨, etc.). Color and emphasis are conveyed through CSS and bold labels.	🟢	No emoji characters occur in the file; tiering is carried by <strong> labels and the .benefits / .risks CSS palettes.
4.5	The QRS is designed to render on one A4 page. Any section that has more content in the ER than fits the per-section budget is condensed by the LLM, not extended onto a second page.	🟢	Each section is condensed rather than transcribed: four multi-paragraph benefit tiers collapse to four one-line entries, eight risk subsections to four, and the ER’s prose monitoring cadence to a single sentence.

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5. Metadata

#	Description	Result	Comments
5.1	The metadata is placed inside a single HTML comment that is the first element after “<!doctype html>” and before any other comment, head, or body content.	🟢	Lines 2–14; the only preceding content is <!doctype html> on line 1.
5.2	Inside that HTML comment the YAML block is delimited by a line “—” opening and a line “—” closing. Text before the opening “—” is permitted but is not parsed as YAML.	🟢	Opening --- at line 3, closing --- at line 13; the preamble “QRS — Metadata (invisible, parsed by audit tooling)” sits above the opening delimiter.
5.3	The metadata is not visible in any rendered view of the QRS and is not surfaced by any other element on the sheet.	🟢	Enclosed in an HTML comment; no metadata value is echoed into the body except the header date and model, which are their own variables.
5.4	All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting.	🟢	Only duration: "00:03" is quoted, correctly so because it contains a colon; all other values are bare and trimmed.
5.5	The filename of the source ER is stated as “er_filename: [er_filename]”	🟢	Line 4: er_filename: manuka_honey_2026-0904-0002_Opus_ER.md, matching the ER’s own filename frontmatter field.
5.6	Version of the QRS.md file used to create the document is stated as “qrs_prompt_version: [Version of QRS.md]”	🟢	Line 5: qrs_prompt_version: 26.7.02, matching the version badge at the top of QRS.md.
5.7	Creation date and time of the document is stated as “qrs_creation_date: [YYYY-MMDD-HHMM]” (e.g., 2026-0501-1430)	🟢	Line 6: qrs_creation_date: 2026-0904-0123, correct YYYY-MMDD-HHMM form.
5.8	The nickname of the AI used to create the document is stated as “qrs_creator_ai_nickname: [qrs_creator_ai_nickname]”	🟢	Line 7: qrs_creator_ai_nickname: Opus.
5.9	The nickname of the AI is just a single word model name without version, etc. (e.g., Opus, Sonnet, Grok, Gemini, ChatGPT)	🟢	“Opus” is a single word with no version or qualifier.
5.10	The full name of the AI used to create the document is stated as “qrs_creator_ai_fullname: [qrs_creator_ai_fullname]”	🟢	Line 8: qrs_creator_ai_fullname: Opus 5.
5.11	The full name of the AI consists of the [qrs_creator_ai_nickname] and the model version number and no additional qualifier (e.g., Opus 4.6, Sonnet 3.2, Grok 4.5, Gemini 3.1, ChatGPT 5.4)	🟢	“Opus 5” is nickname plus version with no trailing qualifier.
5.12	The filename of the document is stated as “qrs_filename: [filename of this document]”	🟢	Line 9: qrs_filename: manuka_honey_2026-0904-0002_Opus_QRS.html, matching the file on disk.
5.13	All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting.	🟢	Re-verified across all nine keys including the workflow-added git_user and git_issue; no stray whitespace or unnecessary quoting.

6. Page Title & Header

#	Description	Result	Comments
6.1	[page_title] is set to the [canonical_topic] of the ER frontmatter followed by “ - Quick Reference Sheet” (e.g., “Intervention - Quick Reference Sheet”). The [canonical_topic] is HTML-entity-encoded as needed (e.g., & for &)	🟢	Line 22: “Manuka Honey for Health & Longevity - Quick Reference Sheet”; the ampersand is correctly entity-encoded.
6.2	[header_topic] is set to the [canonical_topic] of the ER frontmatter, with HTML entities encoded as needed (e.g., & for &)	🟢	Line 417: “Manuka Honey for Health & Longevity”, matching ER frontmatter canonical_topic.
6.3	[header_subline_date] is set to [qrs_creation_date reformatted as MM/DD/YYYY]	🟢	Line 421: “09/04/2026”, the correct MM/DD/YYYY rendering of 2026-0904-0123.
6.4	[header_subline_model] is set to [qrs_creator_ai_fullname]	🟢	Line 425: “Opus 5”, matching the frontmatter qrs_creator_ai_fullname.
6.5	No additional header content appears: no badge, version stamp, AKA / alternate names line, source-AI attribution, audit date, or QRS variant marker.	🟢	The header holds only the title and the template subline; the ER’s “Also known as” list is not carried over.

7. At-A-Glance Section

#	Description	Result	Comments
7.1	[at_a_glance] is dense, execution-oriented summary of the ER Conclusion section	🟢	Compresses all three ER Conclusion paragraphs into the decision that matters: topical works, oral largely does not, and the evidence base is commercially funded.
7.2	[at_a_glance] is no longer than 60 words	🟢	55 words.
7.3	Every fact in [at_a_glance] is supported by a distinct passage in the ER.	🟢	Surface-contact efficacy and the “spoonful of sugar that digestion mostly destroys” line trace to ER line 531; the funding caveat to ER line 535.
7.4	It DOES NOT use acronyms or technical classifications that require specialist knowledge, uses plain-language terms instead	🟢	Uses “bacteria-killing compound” rather than “antibacterial”/”methylglyoxal”; no acronyms or evidence-grade classifications appear.
7.5	It DOES NOT cite specific trials (names, years, sample sizes, p-values)	🟢	No trial names, years, sample sizes or p-values.
7.6	It DOES NOT cite effect sizes, relative risks, or statistical results	🟢	No numeric results of any kind.

8. Contraindications

#	Description	Result	Comments
8.1	The section is derived from the ER Key Interactions & Contraindications section	🟢	All five items map to the ER’s “Populations who should avoid Manuka Honey” list (ER lines 360–364).
8.2	[stop_items] represent the Contraindications from the ER	🟢	All five ER avoid-populations are present, none added: infants, honey/bee/Compositae allergy, severe immunosuppression, poorly controlled type 2 diabetes, hereditary fructose intolerance.
8.3	Individual [stop_items] are formatted as <li></li>	🟢	Five <li> elements at lines 565–577 inside the stop_items span.
8.4	Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact.	🟢	The ER’s trailing rationales (“because of botulism spore risk”, “because of anaphylaxis risk”, “for whom the fructose content is an absolute contraindication”) are all stripped; no dash-trailing clauses remain.
8.5	Parenthetical qualifiers from the ER bullet — time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely).	🟢	“under 12 months”, “(mugwort, ragweed, chamomile)”, “<500/µL”, “<200/µL” and “>8%” are all retained, along with the scope restrictions “gamma-irradiated medical-grade honey only” and “no therapeutic oral dosing”.
8.6	When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol.	N/A	The ER’s contraindication bullets use no ranking notation inside parentheses.
8.7	The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no population, condition, or scenario for which the intervention should be avoided, deferred, or used only under specialist supervision.	N/A	The section is populated; the ER names five avoid-populations.
8.8	If the section is left empty, an HTML comment inside the [stop_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g.	N/A	The section is not empty.

9. Key Interactions

#	Description	Result	Comments
9.1	The section is derived from the ER Key Interactions & Contraindications section	🟢	All nine items map one-to-one to the ER’s nine interaction bullets (ER lines 340–356).
9.2	[caution_items] represent the Key Interactions from the ER, excluding any that are already listed as Contraindications	🟢	All nine ER interactions are present and none duplicates a contraindication.
9.3	Individual [caution_items] are formatted as <li></li>	🟢	Nine <li> elements at lines 585–595 inside the caution_items span.
9.4	Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact.	🟢	Every ER severity label (“Caution”, “Additive”, “Potentiating”) and every mitigation clause is stripped; the ER’s “Other interventions — “ dash prefix is removed from the sinus/eye-drop item.
9.5	Parenthetical qualifiers from the ER bullet — example drug lists, time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely).	🟢	Named drug lists are retained for all four bullets that carry them: (metformin, sulfonylureas, insulin), (statins, tacrolimus, calcium-channel blockers), (berberine, chromium, cinnamon extract, alpha-lipoic acid), (silver, iodine, chlorhexidine).
9.6	When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol.	N/A	The ER’s interaction parentheticals are plain comma-separated drug lists with no ranking notation.
9.7	The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no interaction, additive effect, or exposure that changes how the intervention is used.	N/A	The section is populated; the ER names nine interactions.
9.8	If the section is left empty, an HTML comment inside the [caution_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g.	N/A	The section is not empty.

10. Protocol

#	Description	Result	Comments
10.1	The section is derived from the ER Protocol section	🟢	All three cells derive from ER Therapeutic Protocol bullets at lines 390, 392 and 400.
10.2	The three sets of [action] items cover the three most important actionable implementation aspects from the ER Protocol section	🟢	The two dose-defining bullets (oral, topical wound) plus timing are the only directly actionable bullets; the remainder of the ER section covers competing approaches, attribution, half-life and modifier factors.
10.3	If less that three distinct actionable implementation aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing.	N/A	The ER supplies at least three actionable aspects and all three sets are populated.
10.4	All used [action_#label], [action#value], [action#_sub] items are filled with meaningful content derived from the ER Protocol section.	🟢	All nine spans carry ER-derived content: “5–21 g, 1–3× daily” / “UMF 10+ or higher, taken neat and held in the mouth”; “20 g per 10 cm²” / dressing and change interval; “After the evening meal” / “Last dose before lying down; dosing on an empty stomach is avoided”.

11. Time to Effect

#	Description	Result	Comments
11.1	The three sets of [time] items cover the three most important time-to-effect aspects from the ER	🟢	The ER’s Practical Considerations “Time to effect” bullet (line 456) names exactly three windows — wound closure, dry eye/eyelid, throat and reflux — and all three are carried.
11.2	The sets are picked and ordered by the magnitude of the related benefit	🟢	Ordered wound closure (High tier), dry eye and eyelid (High tier), throat and reflux (Medium/Low tiers) — a deliberate reordering of the ER’s own sequence to follow benefit magnitude.
11.3	If less that three distinct time-to-effect aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing.	N/A	Three distinct time-to-effect aspects exist and all three sets are populated.
11.4	All used [time_#label], [time#value], [time#_sub] items are filled with meaningful content derived from the ER.	🟢	“Weeks to months”, “3 to 12 weeks” and “Days to two weeks” reproduce the ER’s three stated windows, each with a sourcing sub-line.
11.5	If the ER does not provide any information on time to effect, the section is removed completely from the Protocol Panel	N/A	The ER provides time-to-effect information, so the section is correctly retained.

12. Benefits

#	Description	Result	Comments
12.1	The section is derived from the ER Expected Benefits section	🟢	All twelve entries map to the twelve ER Expected Benefits subsection headings across the four tiers.
12.2	Key variables are [benefits_high], [benefits_medium], [benefits_low], [benefits_speculative]	🟢	All four spans present and populated at lines 532, 538, 544 and 551.
12.3	Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact.	🟢	Each tier is a semicolon-joined list of condensed ER headings; every ER “Magnitude” figure, mechanism sentence and evidence-quality caveat is dropped.
12.4	Parenthetical content — including effect sizes, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved.	🟢	No parentheses occur in any benefits span; the ER’s glosses such as “(blockage of the eyelid oil glands)” are absent.
12.5	If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing.	N/A	All four ER benefit tiers contain items, so no span needed hiding.

13. Risks

#	Description	Result	Comments
13.1	The section is derived from the ER Potential Risks & Side Effects section	🟢	All nine entries map to the nine ER Potential Risks & Side Effects subsection headings.
13.2	Key variables are [risks_high], [risks_medium], [risks_low], [risks_speculative]	🟢	All four spans present and populated at lines 607, 613, 616 and 623.
13.3	Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact.	🟢	Withdrawal percentages, outbreak case counts, pooled pain-score findings and all mechanism sentences from the ER are dropped; only the condensed headings remain.
13.4	Parenthetical content — including frequencies, severity grades, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved.	🟢	No parentheses occur in any risks span.
13.5	If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing.	N/A	All four ER risk tiers contain items, so no span needed hiding.

14. Monitoring

#	Description	Result	Comments
14.1	The section is derived from the ER Monitoring section	🟢	All rows and the cadence line derive from the ER Monitoring Protocol & Defining Success section (ER lines 486–500).
14.2	All measurable/quantifiable biomarkers from the Monitoring section are listed	🟢	All nine ER biomarker-table rows are present in ER order: fasting glucose, HbA1c, fasting insulin, triglycerides, hs-CRP, post-dose CGM rise, waist-to-height ratio, serum total IgE, wound swab culture.
14.3	[monitoring_cadence] is populated with the monitoring cadence/frequency derived from the ER Monitoring section. It is not left with placeholder text or empty.	🟢	Line 753 carries the full cadence: baseline panel, symptom scores at 4 weeks, metabolic panel at 12 weeks, then every 6–12 months, with wound swabs only on changing clinical signs — matching ER lines 486 and 488.

15. Qualitative Assessment

#	Description	Result	Comments
15.1	The section is derived from the ER Monitoring section	🟢	All six items come from the ER’s “Qualitative markers worth tracking” list (ER lines 504–509).
15.2	All subjective/qualitative biomarkers from the Monitoring section are listed	🟢	All six ER qualitative markers are present verbatim and in ER order.

Issues 04/09/2026 01:45

Pass rate 100.00%. No issues found.

Issues 04/09/2026 01:33

1. 4.5 — Sheet overruns one A4 page: The populated blocks total roughly 477 mm against the 273 mm printable height (.sheet { padding: 12mm } with @page { margin: 0 }), about 175% of one page; monitoring (~113 mm, lines 641–771), the gates row (~84 mm, lines 563–605) and the protocol panel (~66 mm, lines 444–529) are the largest overruns, and no per-section condensation was applied to any variable.

Fixes 04/09/2026 01:33

1. 4.5 — Monitoring table condensed: Shortened six biomarker target and why cells so eight of the nine rows now set on a single line — [marker_5_why] “Tracks the inflammatory direction of travel” → “Tracks inflammation over time”, [marker_6_target] → “Under 30 mg/dL above baseline at 60–90 min”, [marker_6_why] → “Individual response to one serving”, [marker_8_why] → “Screens for allergic reactivity”, [marker_9_target] → “No established target; track clearance of baseline organism”, [marker_9_why] → “Confirms control of colonisation”. All nine ER biomarkers and their functional ranges are retained.
2. 4.5 — Monitoring cadence trimmed: [monitoring_cadence] reduced from three rendered lines to two by dropping the redundant “re-checked”/”repeated” verbs, keeping the baseline / 4-week / 12-week / 6–12-month schedule and the wound-swab condition intact.
3. 4.5 — Protocol cells condensed: [action_1_sub] “One teaspoon to one tablespoon of UMF 10+ or higher…” → “UMF 10+ or higher, taken neat and held in the mouth” (the 5–21 g range already sits in [action_1_value]); [action_2_sub] → “Sterilised medical-grade dressing, absorbent cover, changed every 1–3 days”; [action_3_sub] → “Last dose before lying down; dosing on an empty stomach is avoided”.
4. 4.5 — Time-to-effect subs condensed: All three [time_#_sub] cells reduced from two lines to one — “Measured in wound-closure trials”, “Measured in dry-eye and eyelid trials”, “Symptom relief appears in this window”.
5. 4.5 — Benefits and gate items condensed: [benefits_low] cut from three lines to two (“Upper respiratory symptom relief; less severe radiotherapy mouth ulceration; …; less dental plaque”); the immunosuppression and diabetes contraindications and the first two interaction items were tightened (“neutrophils <500/µL”, “glycated haemoglobin >8%”, “Glucose-lowering drugs”, “CYP3A4-handled drugs”) with every parenthetical qualifier and named example drug preserved per items 8.5 and 9.5.
6. 4.5 — Residual overrun: The sheet still exceeds one A4 page (estimated ~446 mm against 273 mm printable, down from ~477 mm). Further reduction would require dropping biomarkers, interactions or qualitative markers that items 14.2, 15.2 and 9.2 require to be listed in full, so no content was removed.