Microdosing Amanita muscaria means taking small, regular amounts of the fly agaric mushroom, mainly for stress, sleep and mood. Support rests on user reports, animal and laboratory work and a related sleep drug; no controlled human study has tested the practice. Harm reports are more consistent: confusion, deep sedation, seizures and rare deaths after larger amounts. Strength varies widely, many products are mislabeled, and the mushroom collects heavy metals. (Full Review)
| Marker | Target | Why |
|---|---|---|
| eGFR (estimated glomerular filtration rate) | >90 mL/min/1.73 m² | Main route of clearance |
| ALT (alanine aminotransferase) | <25 U/L | Liver stress check |
| Prolactin | Men 2–15 ng/mL; women 3–20 ng/mL | Muscimol raises it |
| Blood lead | <1 µg/dL | Mushroom accumulates lead |
| Blood cadmium | <0.5 µg/L | Mushroom accumulates cadmium |
| Blood mercury | <3 µg/L | Mushroom accumulates mercury |
| Resting heart rate | 50–70 beats per minute | Detects cholinergic slowing |
| Blood pressure | <120/80 mmHg | Detects cardiovascular effects |
| PSQI (Pittsburgh Sleep Quality Index) | ≤5 | Tracks sleep quality |
| GAD-7 (anxiety scale) | <5 | Tracks anxiety |
| PHQ-9 (depression scale) | <5 | Tracks mood |
Cadence: Baseline before starting; questionnaires and heart rate at 2 and 4 weeks; blood pressure morning and evening in the first two weeks; kidney and liver function and prolactin at 8–12 weeks, then every 3–6 months during continued courses; heavy metals every 6–12 months with long-term use