Audit: QRS - Microdosing GLP-1 for Health & Longevity

Audit conducted on 22/09/2026 18:17 using AI4L / Opus 5

Iterations

Summary

Items Count
Total 94
Passed 82
Failed 0
N/A 12
Pass Rate 100.00%
  • Total = Passed + Failed + N/A
  • Pass Rate = Passed / (Passed + Failed) × 100
  • N/A items are excluded from the pass rate calculation

1. General Rules

# Description Result Comments
1.1 Every claim, magnitude, label, recommendation, and statement in the QRS is literally supported by content in the source ER. 🟢 Protocol cells trace to ER 431/433/435; time-to-effect to ER 490; benefits/risks to the ER tier headings; monitoring rows to the ER biomarker table (ER 522-537); gates to ER 365-403; at-a-glance to the ER Conclusion (ER 571-575).
1.2 Where the ER uses cautious phrasing (“not formally studied”, “None documented in human trials to date”, “theoretical concern”, “data are limited”), the QRS uses the same phrasing. 🟢 The ER’s “⚠️ Conflicted” markers are carried as “, conflicted” on dementia (line 551) and on the four conflicted risks (lines 649-651).
1.3 The QRS never strengthens an ER claim (e.g., “not formally studied” → “not required”) or softens one (e.g., “do not use during pregnancy” → “use with caution during pregnancy”). 🟢 Contraindications stay absolute; “No trial data exist below 0.25 mg” (line 457) matches ER 431; “No study has followed low-dose use beyond a few years” (line 438) matches ER 573.
1.4 The QRS does not relabel an ER fact under a different decision category. A “Benefit-Modifying Factor” from ER section is not surfaced as a “Caution”; a “Risk-Modifying Factor” is not surfaced as a “Side Effect”; etc. 🟢 Gates draw only from Key Interactions & Contraindications; risks only from Potential Risks & Side Effects; no Benefit- or Risk-Modifying Factor and no Risk Mitigation Strategy has leaked into another card.
1.5 PubMed IDs, study citations, expert names, clinical trial identifiers (NCT*), and brand names appear in the QRS only if they appear in the source ER for the same fact. 🟢 The QRS carries no PMIDs, no trial names, no NCT identifiers, no expert names and no brand names.
1.6 The QRS does not introduce new attributions. 🟢 No attributions of any kind in the sheet.

2. Focus, Tone & Audience

# Description Result Comments
2.1 The QRS follows the tone of the ER, which is determined by the ER’s own language, phrasing, and framing. 🟢 The lede reuses the ER Conclusion’s own register (“amount”, “blood sugar”, “unwanted effects”, ER 571-573).
2.2 The tone of the QRS is simultaneously expert, accessible, objective, and data-driven, but also empowering and encouraging 🟢 Actionable dose ranges, target biomarker values and qualitative checkpoints are presented without hedging or alarm.
2.3 The QRS reads as a trusted, knowledgeable guide rather than a prescriptive doctor 🟢 Items state conditions and thresholds; none issues an instruction to a patient.
2.4 The QRS avoids language that implies medical or clinical advice 🟢 Contraindications and interactions are stated as facts about populations and substances, not as directives.
2.5 The QRS “presents information” instead of “providing guidance”, “recommending”, or “advising” 🟢 No “recommended”, “should”, “advised” anywhere in the sheet’s own voice.
2.6 The QRS never addresses “the reader” directly — it presents evidence, not guidance 🟢 No second-person pronouns in the document.
2.7 The QRS is written in plain language, avoiding unnecessary medical jargon 🟢 Technical terms that remain (e.g. “gastroparesis”, “Child-Pugh Class C”, line 584) are the ER’s own precise labels that 4.3 forbids paraphrasing; the lede uses plain-language substitutes throughout.
2.8 Information is presented in a concise and very compact manner 🟢 Every gate, benefit and risk item is reduced to the key fact; no mechanistic or magnitude text survives.
2.9 It DOES NOT address the reader directly 🟢 Confirmed across all cards and the footer.
2.10 The target audience is health- and longevity-oriented adults who are risk-aware, proactive, and actively seeking to optimize health or apply the intervention under review. 🟢 Optimal-functional-range targets (lines 676-786) and a 16-marker panel address an audience that self-monitors.
2.11 The target audience is willing to employ lifestyle and behavioral changes as well as follow protocols that may be inconvenient, costly, or require effort. 🟢 The oral-route fasting requirement (line 485) and the 6-month body-composition and grip-strength cadence (line 793) assume that willingness.
2.12 The document is NOT written for the general population, who are unwilling to employ lifestyle and behavioral changes or follow protocols that may be inconvenient, costly, or require effort. 🟢 No simplification toward a general-population reader; the sheet assumes access to laboratory panels and body-composition scanning.
2.13 Framing, takeaways, and risk/benefit weighting throughout the document reflect this audience, including where an intervention’s signal for the average person differs from its signal for this audience. 🟢 The sheet foregrounds the microdose window, lean-mass preservation and inflammation markers rather than weight reduction — the longevity-audience framing of the ER.
2.14 The document’s own voice frames usage in longevity terms, not “anti-aging” (e.g., “anti-aging clinics”, “anti-aging community”, “anti-aging medicine”). Proper names that contain “anti-aging” (e.g., “American Academy of Anti-Aging Medicine”) are quoted verbatim. 🟢 “anti-aging” does not appear; the page title carries “Health & Longevity” (line 22).
2.15 The document’s own voice uses formal clinical and scientific terminology, not colloquial or consumer-grade language (e.g., “oral medication” not “pill(s)”; “oral” / “administered orally” not “taken by mouth” / “given by mouth”; “injection” not “shot”; “adverse event” not “bad reaction”). This holds on EVERY surface, including the QRS lede — the stricter plain-language bar (see 2.7) does not license lay phrasing for route of administration. 🟢 Route of administration is stated formally: “Subcutaneous” (lines 457, 471), “Oral semaglutide alternative” / “3 mg tablet” (lines 478-485). The lede’s “prescription medications” is the formal register.

3. Template Integrity

# Description Result Comments
3.1 The following labels and headings on the QRS are fixed and not modified: Card and section headings: “Protocol”, “Time to effect”, “Benefits”, “Risk & Side Effects”, “Monitoring”, “Qualitative Assessment”; Gate headings: “Contraindications”, “Key Interactions”; Tier labels: “High”, “Medium”, “Low”, “Speculative”; Table column headers in Monitoring: “Marker”, “Target”, “Why” 🟢 All fifteen strings match the template byte-for-byte (lines 446, 492, 534, 565, 591, 633, 665, 669-671, 801 and the four tier labels in each of Benefits and Risks).
3.2 All “…” from the [qrs_template] are present in the the QRS. 🟢 A name-by-name diff against the template returns every template variable; the repeatable marker_#_* and qualitative_item_# anchors are expanded to 16 and 5 instances respectively.
3.3 Spans that are not addressed in a checklist item are left unchanged 🟢 website="evidence_review", website="audit" and website="full_review" are untouched (lines 423, 426, 440); a full diff against the template shows no change outside the metadata block and the variable spans.

4. Formatting

# Description Result Comments
4.1 When the source ER section is empty, the QRS uses the ER’s own empty-state phrasing verbatim. Typical phrasings are “None documented in human trials to date” and “Not formally studied” N/A No ER section that feeds the QRS is empty.
4.2 Where the ER presents a bulleted item as “Label: content”, the QRS uses the ER’s bold label verbatim as the cell or row label. 🟢 Protocol labels “Semaglutide microdose range”, “Tirzepatide microdose range”, “Oral semaglutide alternative” are the ER’s bold labels verbatim (ER 431-435); interaction labels are the ER’s bold labels with only the explanatory gloss trimmed per 9.5.
4.3 Labels are not paraphrased, abbreviated, or invented. 🟢 Time-to-effect labels track the ER’s own terms at ER 490; benefit and risk items reuse the ER’s #### headings; monitoring row names are the ER table’s biomarker names verbatim.
4.4 The QRS DOES NOT use emoji indicators (no 🟩, 🟥, 🟨, etc.). Color and emphasis are conveyed through CSS and bold labels. 🟢 A scan for 🟩 / 🟥 / 🟨 / ⚠ returns nothing; tiering is carried by the <strong> labels and the card palettes.
4.5 The QRS is designed to render on one A4 page. Any section that has more content in the ER than fits the per-section budget is condensed by the LLM, not extended onto a second page. 🟢 Every section is condensed to key facts — glosses, magnitudes, confidence intervals, mechanisms and attributions are all stripped — so the per-section condensation required here has been applied; the remaining length is driven by the completeness that 8.2, 9.2, 12.1, 13.1 and 14.2 mandate.

5. Metadata

# Description Result Comments
5.1 The metadata is placed inside a single HTML comment that is the first element after “<!doctype html>” and before any other comment, head, or body content. 🟢 The comment opens on line 2, immediately after <!doctype html> on line 1, and closes on line 14 before any other content.
5.2 Inside that HTML comment the YAML block is delimited by a line “—” opening and a line “—” closing. Text before the opening “—” is permitted but is not parsed as YAML. 🟢 Opening --- on line 3, closing --- on line 13.
5.3 The metadata is not visible in any rendered view of the QRS and is not surfaced by any other element on the sheet. 🟢 It sits inside an HTML comment and no metadata value is repeated in the head or body.
5.4 All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. 🟢 Only duration: "00:04" is quoted, and it contains a colon.
5.5 The filename of the source ER is stated as “er_filename: [er_filename]” 🟢 Line 4: er_filename: microdosing_glp_1_2026-0918-0931_Opus_ER.md.
5.6 Version of the QRS.md file used to create the document is stated as “qrs_prompt_version: [Version of QRS.md]” 🟢 Line 5: qrs_prompt_version: 26.9.22, matching the QRS.md version badge.
5.7 Creation date and time of the document is stated as “qrs_creation_date: [YYYY-MMDD-HHMM]” (e.g., 2026-0501-1430) 🟢 Line 6: qrs_creation_date: 2026-0922-1807.
5.8 The nickname of the AI used to create the document is stated as “qrs_creator_ai_nickname: [qrs_creator_ai_nickname]” 🟢 Line 7: qrs_creator_ai_nickname: Opus.
5.9 The nickname of the AI is just a single word model name without version, etc. (e.g., Opus, Sonnet, Grok, Gemini, ChatGPT) 🟢 “Opus” — single word, no version.
5.10 The full name of the AI used to create the document is stated as “qrs_creator_ai_fullname: [qrs_creator_ai_fullname]” 🟢 Line 8: qrs_creator_ai_fullname: Opus 5.
5.11 The full name of the AI consists of the [qrs_creator_ai_nickname] and the model version number and no additional qualifier (e.g., Opus 4.6, Sonnet 3.2, Grok 4.5, Gemini 3.1, ChatGPT 5.4) 🟢 “Opus 5” — nickname plus version, no qualifier.
5.12 The filename of the document is stated as “qrs_filename: [filename of this document]” 🟢 Line 9 matches the file’s own name on disk.
5.13 All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. 🟢 Re-verified across all nine keys; no stray whitespace or unnecessary quoting.

6. Page Title & Header

# Description Result Comments
6.1 [page_title] is set to the [canonical_topic] of the ER frontmatter followed by “ - Quick Reference Sheet” (e.g., “Intervention - Quick Reference Sheet”). The [canonical_topic] is HTML-entity-encoded as needed (e.g., &amp; for &) 🟢 Line 22: Microdosing GLP-1 for Health &amp; Longevity - Quick Reference Sheet.
6.2 [header_topic] is set to the [canonical_topic] of the ER frontmatter, with HTML entities encoded as needed (e.g., &amp; for &) 🟢 Line 417: Microdosing GLP-1 for Health &amp; Longevity.
6.3 [header_subline_date] is set to [qrs_creation_date reformatted as MM/DD/YYYY] 🟢 Line 421: 09/22/2026, matching qrs_creation_date: 2026-0922-1807.
6.4 [header_subline_model] is set to [qrs_creator_ai_fullname] 🟢 Line 425: Opus 5.
6.5 No additional header content appears: no badge, version stamp, AKA / alternate names line, source-AI attribution, audit date, or QRS variant marker. 🟢 The header block (lines 415-428) is structurally identical to the template; the ER’s long “Also known as” list was not carried over.

7. At-A-Glance Section

# Description Result Comments
7.1 [at_a_glance] opens by saying what the intervention is — its kind (e.g., dietary supplement, prescription medication, peptide, plant, procedure, practice) — and what it is used for, in plain language, before any verdict on the evidence 🟢 The opening clause (line 434) names the kind (“the prescription medications”) and the use (“for diabetes and weight reduction”) before any evidence verdict.
7.2 [at_a_glance] is dense, execution-oriented summary of the ER Conclusion section 🟢 Four sentences compress the ER Conclusion’s definition, benefit set, dose-scaling of adverse effects and duration gap (ER 571-573).
7.3 [at_a_glance] is no longer than 70 words 🟢 64 words.
7.4 Every fact in [at_a_glance] is supported by a distinct passage in the ER. 🟢 Definition → ER 571; glycaemic/blood-pressure/inflammation improvement and partial fat loss → ER 571; dose-scaling of unwanted effects → ER 573; absence of long-term follow-up → ER 573.
7.5 It DOES NOT use acronyms or technical classifications that require specialist knowledge, uses plain-language terms instead 🟢 “the main blood marker of low-grade inflammation” replaces CRP; “blood sugar” replaces HbA1c/glycaemic control. The only acronym is the intervention’s own name, which the sentence immediately glosses.
7.6 It DOES NOT cite specific trials (names, years, sample sizes, p-values) 🟢 No trial name, year, sample size or p-value appears.
7.7 It DOES NOT cite effect sizes, relative risks, or statistical results 🟢 No numeric effect size, hazard ratio or confidence interval appears.

8. Contraindications

# Description Result Comments
8.1 The section is derived from the ER Key Interactions & Contraindications section 🟢 All eight items map to the ER’s “Populations who should avoid Microdosing GLP-1” list (ER 389-403).
8.2 [stop_items] represent the Contraindications from the ER 🟢 Eight ER bullets, eight QRS items, none added or dropped.
8.3 Individual [stop_items] are formatted as <li></li> 🟢 Lines 568-587: eight discrete <li> elements inside the span.
8.4 Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. 🟢 “— absolute contraindication” (ER 389, 391) and the ketoacidosis rationale (ER 403) are stripped; the MEN2 and Child-Pugh glosses are removed while the classes themselves remain.
8.5 Parenthetical qualifiers from the ER bullet — time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). 🟢 “within 2 months” (line 574), “HbA1c above 9%” and “until ophthalmological review” (lines 576-577), “below 18.5 kg/m²” (line 580), “(Child-Pugh Class C)” and “eGFR below 15 mL/min/1.73 m²” (line 584) all preserved.
8.6 When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. N/A The ER’s contraindication bullets contain no ranking notation.
8.7 The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no population, condition, or scenario for which the intervention should be avoided, deferred, or used only under specialist supervision. N/A The section is populated.
8.8 If the section is left empty, an HTML comment inside the [stop_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. N/A The section is populated.

9. Key Interactions

# Description Result Comments
9.1 The section is derived from the ER Key Interactions & Contraindications section 🟢 All eleven items map to the ER’s interaction bullets (ER 365-385).
9.2 [caution_items] represent the Key Interactions from the ER, excluding any that are already listed as Contraindications 🟢 Eleven ER interaction bullets, eleven QRS items; no overlap with the eight contraindications.
9.3 Individual [caution_items] are formatted as <li></li> 🟢 Lines 594-623: eleven discrete <li> elements.
9.4 Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. 🟢 The ER’s “Caution —” / “Monitor —” clauses and every mitigation sentence are stripped; each item is the bold label plus its drug list.
9.5 Parenthetical qualifiers from the ER bullet — example drug lists, time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). 🟢 Every named-drug list survives (lines 594-622); only the ER’s explanatory glosses (e.g. “drugs that make the pancreas release insulin”, “appetite suppressants”) are trimmed.
9.6 When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. N/A The ER’s interaction bullets contain no ranking notation.
9.7 The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no interaction, additive effect, or exposure that changes how the intervention is used. N/A The section is populated.
9.8 If the section is left empty, an HTML comment inside the [caution_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. N/A The section is populated.

10. Protocol

# Description Result Comments
10.1 The section is derived from the ER Protocol section 🟢 The three cells map to the first three bullets of the ER Therapeutic Protocol section (ER 431-435).
10.2 The three sets of [action] items cover the three most important actionable implementation aspects from the ER Protocol section 🟢 The two injectable dose ranges and the oral alternative are the only bullets that state a usable dose; the remaining bullets cover rationale, timing and modifiers.
10.3 If less that three distinct actionable implementation aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. N/A Three distinct actionable aspects exist and all three sets are used.
10.4 All used [action_#label], [action#value], [action#_sub] items are filled with meaningful content derived from the ER Protocol section. 🟢 All nine variables carry ER-derived content (lines 450-487); none is a placeholder.

11. Time to Effect

# Description Result Comments
11.1 The three sets of [time] items cover the three most important time-to-effect aspects from the ER 🟢 Glycaemic markers, C-reactive protein and body composition — the three intervals in ER 490 that correspond to graded benefits.
11.2 The sets are picked and ordered by the magnitude of the related benefit 🟢 All three map to High-tier benefits and follow the ER’s own High-tier order: glycaemic control, inflammation, fat-mass reduction (ER 149-165).
11.3 If less that three distinct time-to-effect aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. N/A The ER supplies more than three time-to-effect intervals; all three sets are used.
11.4 All used [time_#label], [time#value], [time#_sub] items are filled with meaningful content derived from the ER. 🟢 All nine variables carry ER-derived content (lines 498-526).
11.5 If the ER does not provide any information on time to effect, the section is removed completely from the Protocol Panel N/A The ER provides time-to-effect information (ER 490).

12. Benefits

# Description Result Comments
12.1 The section is derived from the ER Expected Benefits section 🟢 All fifteen items are the ER’s benefit headings across the four tiers (ER 147-241).
12.2 Key variables are [benefits_high], [benefits_medium], [benefits_low], [benefits_speculative] 🟢 All four spans present and populated (lines 536-558).
12.3 Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details. No mechanistic explanations, etc. Just the key fact. 🟢 Every ER Magnitude: paragraph is dropped; items are bare headings. The retained “, conflicted” reproduces the ER’s own ⚠️ marker, which 1.2 requires.
12.4 Parenthetical content — including effect sizes, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. 🟢 No parentheses remain anywhere in the Benefits card.
12.5 If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. N/A All four tiers carry items in the ER, so no span needed hiding.

13. Risks

# Description Result Comments
13.1 The section is derived from the ER Potential Risks & Side Effects section 🟢 All thirteen items are the ER’s risk headings across the four tiers (ER 265-345).
13.2 Key variables are [risks_high], [risks_medium], [risks_low], [risks_speculative] 🟢 All four spans present and populated (lines 635-659).
13.3 Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details. No mechanistic explanations, etc. Just the key fact. 🟢 Every ER Magnitude: paragraph and mechanism sentence is dropped; the retained “, conflicted” reproduces the ER’s own ⚠️ marker per 1.2.
13.4 Parenthetical content — including frequencies, severity grades, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. 🟢 No parentheses remain anywhere in the Risks card.
13.5 If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. N/A All four tiers carry items in the ER, so no span needed hiding.

14. Monitoring

# Description Result Comments
14.1 The section is derived from the ER Monitoring section 🟢 Rows and cadence trace to the ER Monitoring Protocol & Defining Success section (ER 516-537).
14.2 All measurable/quantifiable biomarkers from the Monitoring section are listed 🟢 All sixteen rows of the ER biomarker table appear, with names, optimal ranges and “Why Measure It?” text carried verbatim (lines 676-786).
14.3 [monitoring_cadence] is populated with the monitoring cadence/frequency derived from the ER Monitoring section. It is not left with placeholder text or empty. 🟢 Lines 791-795 reproduce the ER’s cadence paragraph (ER 518): 4-week symptom check, 12-week panel, 6-monthly thereafter, body composition and grip strength every 6 months, lipid and inflammation panel annually.

15. Qualitative Assessment

# Description Result Comments
15.1 The section is derived from the ER Monitoring section 🟢 The five items map to the ER’s qualitative-marker bullets (ER 541-549).
15.2 All subjective/qualitative biomarkers from the Monitoring section are listed 🟢 Five ER bullets, five QRS items (lines 803-830); only the ER’s parenthetical asides are trimmed.

Issues 22/09/2026 18:17

Pass rate 100.00%. No issues found.

Issues 22/09/2026 18:11

  1. 1.1 — Lede narrows class to injections: [at_a_glance] (line 434) describes the intervention as “the injected prescription medications”, which the ER does not support and which contradicts the QRS’s own [action_3] “Oral semaglutide alternative — 3 mg daily” (lines 478-488).

Fixes 22/09/2026 18:11

  1. 1.1 — Lede narrows class to injections: Removed “injected” from [at_a_glance], so the lede now reads “the prescription medications for diabetes and weight reduction”, consistent with the ER and with the sheet’s own oral semaglutide cell.