NAD+, a molecule every cell uses to make energy and power repair enzymes, is promoted for longevity as clinic infusions and supplements. One controlled study found short infusion courses improved heart pumping in heart failure; other direct evidence is thin. Vitamin B3 relatives raise blood levels but show small, inconsistent or absent effects, and worsened early Parkinson's symptoms. Fast infusions often cause nausea and chest pressure. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Blood pressure | No established target; compare with own pre-infusion reading | Infusion reactions and possible additive lowering |
| Resting heart rate | 60–100 beats/min | Rapid infusions raise heart rate |
| Fasting glucose | 70–99 mg/dL | Niacin-type precursors can raise glucose |
| HbA1c | 4.0–5.6% | Detects sustained glucose rise |
| ALT and AST | ALT about 7–56 U/L, AST about 8–33 U/L | Liver strain from high vitamin B3 loads |
| Creatinine | About 0.74–1.35 mg/dL (men), 0.59–1.04 mg/dL (women) | NAD+ breakdown products leave through the kidneys |
| Whole-blood NAD+ | No established target; track change from own baseline | Optional; only confirms uptake |
Cadence: Baseline before starting; blood pressure and heart rate before, during and after every infusion; laboratory tests at 4 weeks, at 3 months, then every 6–12 months while use continues