Naringin is a natural compound found in citrus fruits, most abundant in grapefruit, that the body converts into active naringenin. Animal and laboratory research suggests it calms inflammation and improves how the body handles fats and sugar, but human evidence is mixed and largely unproven. Its main safety concern is changing how certain medicines are absorbed. (Full Review)
| Marker | Target | Why |
|---|---|---|
| LDL cholesterol | < 100 mg/dL (many target < 80) | Primary lipid target for the metabolic benefit |
| Triglycerides | < 100 mg/dL | Tracks fat-handling improvement |
| HDL cholesterol | > 50 (women) / > 40 (men) mg/dL, ideally > 60 | Context for overall lipid response |
| Fasting glucose | 70–85 mg/dL | Detects blood-sugar effect |
| HbA1c | < 5.3% | Three-month average blood sugar |
| hs-CRP | < 1.0 mg/L (ideally < 0.5) | Tracks the anti-inflammatory signal |
| ALT | < 25 U/L (men) / < 20 U/L (women) | Screens liver-related effects |
| Adiponectin (optional) | Higher is generally favorable | Mechanistic marker moved in the human trial |
Cadence: Baseline, again at 8–12 weeks, then every 6–12 months if use continues