A form of vitamin B3 that the body converts into an essential coenzyme for energy and DNA repair, which declines with age. It reliably raises this coenzyme in the blood without flushing, but whether that improves health is uncertain: blood pressure and inflammation signals are promising yet inconsistent. Safety looks reassuring, with mild, infrequent side effects. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Whole-blood NAD+ | Individualized (rise from personal baseline) | Confirms the supplement is doing its core job |
| hs-CRP | < 1.0 mg/L | Tracks whether inflammation, where elevated, improves |
| Homocysteine | 6–8 µmol/L | Screens the theoretical methyl-group drain from high-dose use |
| ALT and AST | ALT < 25 U/L (men) / < 20 U/L (women) | Detects the low-probability hepatic stress at higher doses |
| Fasting glucose and HbA1c | Glucose 75–90 mg/dL; HbA1c < 5.4% | Checks whether any metabolic effect materializes |
| Systolic blood pressure | < 120 mmHg | Captures the modest vascular signal most likely in those starting elevated |
Cadence: Baseline before the first dose, repeat at ~8–12 weeks to assess response, then every 6–12 months for safety surveillance