Oroxylum indicum for Health & Longevity - Quick Reference Sheet

Oroxylum indicum for Health & Longevity

Created on 09/24/2026 – Quick Reference based on Evidence Review created using AI4L / Opus 5.5 – Audit

Oroxylum indicum (Indian trumpet tree) is an Asian medicinal plant whose standardized bark extract is sold as a dietary supplement for memory and focus. A single trial in older adults with memory complaints, co-authored by the extract's maker and not independently repeated, found better scores on some memory tasks but not overall thinking. Reported side effects are mild; possible drug interactions matter more. Long-term value remains uncertain. (Full Review)

Protocol

Clinical-trial protocol
500 mg twice daily
Standardized bark extract (10% oroxylin A, 6% chrysin, 15% baicalein), morning and evening, for 12 weeks; the only regimen tested against placebo
Time of day
Morning and early afternoon
Fits the alerting, dopamine-acting profile; post-meal dosing improves digestive tolerance
Lower-dose nootropic approach
100–250 mg once daily
In the morning, for focus; efficacy at these doses is unmeasured
Time to effect
Episodic memory
12 weeks
Memory differences measured at 12 weeks; earlier time points not tested for cognition
Modest weight reduction
12 weeks
Secondary finding of the memory trial that narrowly missed statistical significance; no weight-loss trial exists
Acute alertness
Within hours
User reports only; anecdotal

Benefits

Contraindications
  • Pregnant or breastfeeding women
  • Children and adolescents under 18
  • Bleeding disorders, platelet counts below 100,000/µL, or surgery within 2 weeks
  • Tacrolimus, cyclosporine, or other narrow-margin CYP3A4 drugs
  • Warfarin without INR monitoring
  • Anxiety or panic disorder controlled with benzodiazepines
  • Decompensated liver disease (Child-Pugh Class B or C)
  • Uncontrolled anxiety, insomnia, or bipolar disorder
Key Interactions
  • Drugs cleared by CYP3A4 (simvastatin, atorvastatin)
  • Anticoagulants and antiplatelets (warfarin, apixaban, clopidogrel)
  • Benzodiazepines not used for anxiety or panic (diazepam, alprazolam, lorazepam)
  • Stimulants and dopaminergic drugs (methylphenidate, amphetamine, bupropion, selegiline)
  • Glucose-lowering drugs (metformin, glipizide, insulin, acarbose)
  • NSAIDs (ibuprofen, naproxen, aspirin)
  • Caffeine
  • Dopaminergic nootropics (L-Tyrosine, Mucuna pruriens, phenylethylamine)
  • Scutellaria baicalensis (Chinese skullcap)
  • Antiplatelet supplements (fish oil, Ginkgo biloba, high-dose vitamin E, garlic)
  • Glucose-lowering supplements (berberine, cinnamon, chromium)
  • Piperine (black pepper extract)
  • Surgery and dental procedures

Risk & Side Effects

  • High:
  • Medium: Digestive upset and headache
  • Low: Overstimulation and sleep disruption; laboratory changes in triglycerides, liver enzymes, and urine protein
  • Speculative: Increased bleeding tendency; altered blood levels of medications; organ toxicity and DNA damage

Monitoring

Marker Target Why
ALT 10–25 U/L Liver injury
AST 10–25 U/L Liver or muscle injury
Platelet count (complete blood count) 200,000–300,000/µL Bleeding-risk baseline
Fasting glucose 75–90 mg/dL Metabolic effect; hypoglycemia risk
HbA1c 4.8–5.3% 3-month glucose average
Fasting insulin 2–6 µIU/mL Insulin sensitivity
INR (if on warfarin) Individual therapeutic target, usually 2.0–3.0 Detects interaction
hs-CRP Below 1.0 mg/L Systemic inflammation
Serum BDNF No established target; track change from own baseline Research marker of nerve-cell support
Montreal Cognitive Assessment 26–30 of 30; track change from own baseline Global cognition

Cadence: Baseline panel before starting; liver enzymes and blood counts at 4 and 12 weeks, then every 6–12 months; cognitive testing at 12 weeks, then every 6 months; glucose on the same cadence, more often with glucose-lowering drugs; INR 1–2 weeks after starting or changing dose (warfarin users)

Qualitative Assessment

  • Everyday memory (misplaced items, forgotten names, lost train of thought)
  • Focus and mental energy during demanding tasks
  • Sleep quality and time to fall asleep
  • Digestive comfort
  • Headache frequency
  • Mood and anxiety levels