Audit: QRS - Phosphatidylethanolamine for Health & Longevity

Audit conducted on 14/09/2026 03:42 using AI4L / Opus 5

Iterations

Summary

Items Count
Total 93
Passed 82
Failed 0
N/A 11
Pass Rate 100.00%
  • Total = Passed + Failed + N/A
  • Pass Rate = Passed / (Passed + Failed) × 100
  • N/A items are excluded from the pass rate calculation

1. General Rules

# Description Result Comments
1.1 Every claim, magnitude, label, recommendation, and statement in the QRS is literally supported by content in the source ER. 🟢 Every populated span traces to ER text: protocol cells to ER Therapeutic Protocol, time cells to Practical Considerations / Expected Benefits, gates to Key Interactions & Contraindications, markers and cadence to Monitoring Protocol & Defining Success.
1.2 Where the ER uses cautious phrasing (“not formally studied”, “None documented in human trials to date”, “theoretical concern”, “data are limited”), the QRS uses the same phrasing. 🟢 “No established target” (marker_1_target), “short of statistical significance” (time_3_sub) and “No trial compared timings” (action_2_sub) all mirror the ER’s hedging.
1.3 The QRS never strengthens an ER claim (e.g., “not formally studied” → “not required”) or softens one (e.g., “do not use during pregnancy” → “use with caution during pregnancy”). 🟢 “Pregnancy and lactation” stays in the Contraindications gate, not the Key Interactions gate; the non-significant sleep signal is not upgraded.
1.4 The QRS does not relabel an ER fact under a different decision category. A “Benefit-Modifying Factor” from ER section is not surfaced as a “Caution”; a “Risk-Modifying Factor” is not surfaced as a “Side Effect”; etc. 🟢 Contraindications come only from the ER’s “Populations who should avoid” list; Key Interactions only from the ER’s interaction bullets; no Benefit- or Risk-Modifying Factor is promoted into a gate.
1.5 PubMed IDs, study citations, expert names, clinical trial identifiers (NCT*), and brand names appear in the QRS only if they appear in the source ER for the same fact. 🟢 No PMIDs, NCT identifiers, author names or brand names (B&S Corporation, Sunsho) appear anywhere in the QRS.
1.6 The QRS does not introduce new attributions. 🟢 Only generic trial descriptors (“the athlete trial”, “the cognition trials”) that the ER itself uses.

2. Focus, Tone & Audience

# Description Result Comments
2.1 The QRS follows the tone of the ER, which is determined by the ER’s own language, phrasing, and framing. 🟢 Matches the ER’s sceptical, evidence-first register, including the industry-funding caveat carried into the lede.
2.2 The tone of the QRS is simultaneously expert, accessible, objective, and data-driven, but also empowering and encouraging 🟢 Quantified doses, ranges and targets throughout; framing is neutral and actionable.
2.3 The QRS reads as a trusted, knowledgeable guide rather than a prescriptive doctor 🟢 Presents what trials used rather than issuing instructions.
2.4 The QRS avoids language that implies medical or clinical advice 🟢 No “should”, “must”, “recommended” or “advised” anywhere in the rendered content.
2.5 The QRS “presents information” instead of “providing guidance”, “recommending”, or “advising” 🟢 Protocol cells state the trial-used dose and timing as facts, not prescriptions.
2.6 The QRS never addresses “the reader” directly — it presents evidence, not guidance 🟢 No second-person pronouns in any populated span.
2.7 The QRS is written in plain language, avoiding unnecessary medical jargon 🟢 Technical terms retained (ether subclass, plasmalogen, diacyl) are the intervention’s own chemistry and unavoidable; the lede uses plain equivalents (“cell-membrane building block”, “sea squirt”).
2.8 Information is presented in a concise and very compact manner 🟢 Benefit and risk tiers are collapsed to single semicolon-separated lines; gate items carry no rationale.
2.9 It DOES NOT address the reader directly 🟢 Confirmed by scan for second-person address; none present.
2.10 The target audience is health- and longevity-oriented adults who are risk-aware, proactive, and actively seeking to optimize health or apply the intervention under review. 🟢 Monitoring targets are functional ranges (ALT 10–26 U/L, ferritin 30–100 ng/mL), not conventional reference ranges.
2.11 The target audience is willing to employ lifestyle and behavioral changes as well as follow protocols that may be inconvenient, costly, or require effort. 🟢 Specialty mass-spectrometry plasmalogen assay and a six-marker panel are presented without apology.
2.12 The document is NOT written for the general population, who are unwilling to employ lifestyle and behavioral changes or follow protocols that may be inconvenient, costly, or require effort. 🟢 Assumes baseline lab access and a 12-week/6-month re-test cadence.
2.13 Framing, takeaways, and risk/benefit weighting throughout the document reflect this audience, including where an intervention’s signal for the average person differs from its signal for this audience. 🟢 The lede leads with the unreplicated, industry-funded nature of the evidence — the decision-relevant weighting for this audience.
2.14 The document’s own voice frames usage in longevity terms, not “anti-aging” (e.g., “anti-aging clinics”, “anti-aging community”, “anti-aging medicine”). Proper names that contain “anti-aging” (e.g., “American Academy of Anti-Aging Medicine”) are quoted verbatim. 🟢 “Longevity” appears in the title and header; “anti-aging” appears nowhere.
2.15 The document’s own voice uses formal clinical and scientific terminology, not colloquial or consumer-grade language (e.g., “oral medication” not “pill(s)”; “oral” / “administered orally” not “taken by mouth” / “given by mouth”; “injection” not “shot”; “adverse event” not “bad reaction”). This holds on EVERY surface, including the QRS lede — the stricter plain-language bar (see 2.7) does not license lay phrasing for route of administration. Direct quotes from sources are exempt. 🟢 No “pill”, “shot”, “by mouth” or similar; “Gastrointestinal intolerance”, “Alanine aminotransferase”, “transferrin saturation” used in formal register.

3. Template Integrity

# Description Result Comments
3.1 The following labels and headings on the QRS are fixed and not modified: Card and section headings: “Protocol”, “Time to effect”, “Benefits”, “Risk & Side Effects”, “Monitoring”, “Qualitative Assessment”; Gate headings: “Contraindications”, “Key Interactions”; Tier labels: “High”, “Medium”, “Low”, “Speculative”; Table column headers in Monitoring: “Marker”, “Target”, “Why” 🟢 All headings, gate headings, tier labels and column headers match the template byte-for-byte (lines 446, 492, 542, 568, 587, 611, 634, 638–640, 742).
3.2 All “<span data-qrs-var=”NAME”>…</span>” from the [qrs_template] are present in the the QRS. 🟢 Diff of variable names against the template shows no template variable missing; the repeatable marker_#_* and qualitative_item_# placeholders are correctly expanded to 1–6 and 1–5.
3.3 Spans that are not addressed in a checklist item are left unchanged 🟢 website="evidence_review", website="audit" and website="full_review" spans, the CSS block, the override stylesheet link and the footer disclaimer are all byte-identical to the template.

4. Formatting

# Description Result Comments
4.1 When the source ER section is empty, the QRS uses the ER’s own empty-state phrasing verbatim. Typical phrasings are “None documented in human trials to date” and “Not formally studied” N/A No ER section is empty; the ER’s High-risk tier carries explanatory prose rather than an empty-state phrase, and that tier is handled under 13.5.
4.2 Where the ER presents a bulleted item as “Label: content”, the QRS uses the ER’s bold label verbatim as the cell or row label. 🟢 “Standard ether-phosphatidylethanolamine dose”, “Best time of day” and “Alternative approach — bulk phospholipid” are the ER’s bold labels verbatim (ER lines 328, 336, 330).
4.3 Labels are not paraphrased, abbreviated, or invented. 🟢 Marker names are the ER table’s row labels verbatim; benefit and risk items are the ER’s H4 headings verbatim (case-normalised only).
4.4 The QRS DOES NOT use emoji indicators (no 🟩, 🟥, 🟨, etc.). Color and emphasis are conveyed through CSS and bold labels. 🟢 Scan for tier and warning emoji returns nothing; the ER’s “⚠️ Conflicted” markers were correctly stripped.
4.5 The QRS is designed to render on one A4 page. Any section that has more content in the ER than fits the per-section budget is condensed by the LLM, not extended onto a second page. 🟢 A 459-line ER is condensed into the template’s fixed section budget: four benefit tiers on four lines, four risk tiers on three, gates with no rationale, six monitoring rows. No section was extended.

5. Metadata

# Description Result Comments
5.1 The metadata is placed inside a single HTML comment that is the first element after “<!doctype html>” and before any other comment, head, or body content. 🟢 Lines 2–14, immediately after the doctype on line 1 and before the template comment on line 16.
5.2 Inside that HTML comment the YAML block is delimited by a line “—” opening and a line “—” closing. Text before the opening “—” is permitted but is not parsed as YAML. 🟢 Opening --- at line 3, closing --- at line 13; the “QRS — Metadata” caption precedes the opener.
5.3 The metadata is not visible in any rendered view of the QRS and is not surfaced by any other element on the sheet. 🟢 Enclosed in an HTML comment; no value is duplicated in any rendered element.
5.4 All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. 🟢 Only duration: "00:03" is quoted, correctly so because it contains a colon.
5.5 The filename of the source ER is stated as “er_filename: [er_filename]” 🟢 Line 4: er_filename: phosphatidylethanolamine_2026-0914-0009_Opus_ER.md.
5.6 Version of the QRS.md file used to create the document is stated as “qrs_prompt_version: [Version of QRS.md]” 🟢 Line 5: qrs_prompt_version: 26.9.11, matching the QRS.md version badge.
5.7 Creation date and time of the document is stated as “qrs_creation_date: [YYYY-MMDD-HHMM]” (e.g., 2026-0501-1430) 🟢 Line 6: qrs_creation_date: 2026-0914-0334.
5.8 The nickname of the AI used to create the document is stated as “qrs_creator_ai_nickname: [qrs_creator_ai_nickname]” 🟢 Line 7: qrs_creator_ai_nickname: Opus.
5.9 The nickname of the AI is just a single word model name without version, etc. (e.g., Opus, Sonnet, Grok, Gemini, ChatGPT) 🟢 “Opus” — single word, no version.
5.10 The full name of the AI used to create the document is stated as “qrs_creator_ai_fullname: [qrs_creator_ai_fullname]” 🟢 Line 8: qrs_creator_ai_fullname: Opus 5.
5.11 The full name of the AI consists of the [qrs_creator_ai_nickname] and the model version number and no additional qualifier (e.g., Opus 4.6, Sonnet 3.2, Grok 4.5, Gemini 3.1, ChatGPT 5.4) 🟢 “Opus 5” — nickname plus version, no qualifier.
5.12 The filename of the document is stated as “qrs_filename: [filename of this document]” 🟢 Line 9 matches the actual filename on disk.
5.13 All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. 🟢 Re-verified across all nine keys; no stray whitespace or unnecessary quoting.

6. Page Title & Header

# Description Result Comments
6.1 [page_title] is set to the [canonical_topic] of the ER frontmatter followed by “ - Quick Reference Sheet” (e.g., “Intervention - Quick Reference Sheet”). The [canonical_topic] is HTML-entity-encoded as needed (e.g., &amp; for &) 🟢 Line 22: “Phosphatidylethanolamine for Health & Longevity - Quick Reference Sheet”.
6.2 [header_topic] is set to the [canonical_topic] of the ER frontmatter, with HTML entities encoded as needed (e.g., &amp; for &) 🟢 Line 417: “Phosphatidylethanolamine for Health & Longevity”.
6.3 [header_subline_date] is set to [qrs_creation_date reformatted as MM/DD/YYYY] 🟢 Line 421: “09/14/2026”, matching qrs_creation_date 2026-0914.
6.4 [header_subline_model] is set to [qrs_creator_ai_fullname] 🟢 Line 425: “Opus 5”.
6.5 No additional header content appears: no badge, version stamp, AKA / alternate names line, source-AI attribution, audit date, or QRS variant marker. 🟢 Header holds only the title and the template subline; the ER’s “Also known as” line was not carried over.

7. At-A-Glance Section

# Description Result Comments
7.1 [at_a_glance] is dense, execution-oriented summary of the ER Conclusion section 🟢 Condenses ER lines 450–452: structural molecule not a drug, one subclass at milligram doses, modest signal, failed confirmatory trial, industry funding.
7.2 [at_a_glance] is no longer than 60 words 🟢 59 words.
7.3 Every fact in [at_a_glance] is supported by a distinct passage in the ER. 🟢 Each clause maps to a distinct ER Conclusion sentence (lines 450, 452).
7.4 It DOES NOT use acronyms or technical classifications that require specialist knowledge, uses plain-language terms instead 🟢 No acronyms; “ascidian” rendered as “sea squirt”, “phospholipid” as “cell-membrane building block”.
7.5 It DOES NOT cite specific trials (names, years, sample sizes, p-values) 🟢 Refers only to “small trials” and “a larger trial” with no identifiers.
7.6 It DOES NOT cite effect sizes, relative risks, or statistical results 🟢 No numbers beyond the qualitative “milligram amounts”.

8. Contraindications

# Description Result Comments
8.1 The section is derived from the ER Key Interactions & Contraindications section 🟢 All six items come from the ER’s “Populations who should avoid Phosphatidylethanolamine” list (ER lines 301–306).
8.2 [stop_items] represent the Contraindications from the ER 🟢 All six ER avoid-populations are present, none added.
8.3 Individual [stop_items] are formatted as <li></li> 🟢 Lines 571–582: six discrete <li> elements inside the span.
8.4 Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. 🟢 The ER’s trailing justifications (“where no safety data at any dose exist”, “in whom no trial has been conducted”) are stripped; no dashes carry trailing clauses.
8.5 Parenthetical qualifiers from the ER bullet — time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). 🟢 “Child-Pugh Class C”, “ferritin above 300 ng/mL with transferrin saturation above 45%”, “three or more first-trimester pregnancy losses” and “under 18” all retained.
8.6 When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. N/A The ER’s avoid list uses no ranking notation inside parentheses.
8.7 The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no population, condition, or scenario for which the intervention should be avoided, deferred, or used only under specialist supervision. N/A The section is not empty; the ER names six avoid-populations.
8.8 If the section is left empty, an HTML comment inside the [stop_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. <!– empty: ER names no population that should avoid the intervention –> N/A The section is not empty.

9. Key Interactions

# Description Result Comments
9.1 The section is derived from the ER Key Interactions & Contraindications section 🟢 All eight items come from the ER’s interaction bullets (ER lines 281–297).
9.2 [caution_items] represent the Key Interactions from the ER, excluding any that are already listed as Contraindications 🟢 Eight of the ER’s nine interaction bullets are carried; the omitted “Vitamin E and other lipid-phase antioxidants” is explicitly labelled “no precaution needed” in the ER, so surfacing it in a caution gate would relabel it under a different decision category (see 1.4). The omission is documented in an HTML comment at lines 600–601.
9.3 Individual [caution_items] are formatted as <li></li> 🟢 Lines 590–599: eight discrete <li> elements.
9.4 Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. 🟢 Each item is the drug class alone; the ER’s “— caution:” / “— monitor:” tags and all mechanism and mitigation text are stripped.
9.5 Parenthetical qualifiers from the ER bullet — example drug lists, time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). 🟢 Named example drugs preserved verbatim: (warfarin, apixaban, rivaroxaban), (aspirin, clopidogrel, ticagrelor), (orlistat), (cholestyramine, colesevelam), (prolonged fasting, spermidine, rapamycin).
9.6 When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. N/A The ER’s interaction bullets use no ranking notation inside parentheses.
9.7 The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no interaction, additive effect, or exposure that changes how the intervention is used. N/A The section is not empty; the ER names nine interactions.
9.8 If the section is left empty, an HTML comment inside the [caution_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. <!– empty: ER names no interaction that changes how the intervention is used –> N/A The section is not empty.

10. Protocol

# Description Result Comments
10.1 The section is derived from the ER Protocol section 🟢 All three cells trace to the ER Therapeutic Protocol bullets at lines 328, 330 and 336.
10.2 The three sets of [action] items cover the three most important actionable implementation aspects from the ER Protocol section 🟢 Dose, timing and the bulk-phospholipid alternative are the three decision-relevant bullets; the remaining ER bullets are response modifiers or provenance notes.
10.3 If less that three distinct actionable implementation aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. N/A All three sets are populated; the ER offers more than three aspects.
10.4 All used [action_#label], [action#value], [action#_sub] items are filled with meaningful content derived from the ER Protocol section. 🟢 Nine spans populated; values “1 mg/day”, “Largest fat-containing meal” and “1–3 g/day krill oil” with ER-sourced subs.

11. Time to Effect

# Description Result Comments
11.1 The three sets of [time] items cover the three most important time-to-effect aspects from the ER 🟢 Memory, mood and sleepiness on waking — the three endpoints the ER gives a time window for (ER line 383).
11.2 The sets are picked and ordered by the magnitude of the related benefit 🟢 Memory (High tier) → Mood (Medium) → Sleepiness on waking (Low), matching the ER’s benefit tiers.
11.3 If less that three distinct time-to-effect aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. N/A All three sets are populated.
11.4 All used [time_#label], [time#value], [time#_sub] items are filled with meaningful content derived from the ER. 🟢 “8–12 weeks”, “2–4 weeks” and “2 weeks” with ER-sourced subs (ER lines 177, 169, 383).
11.5 If the ER does not provide any information on time to effect, the section is removed completely from the Protocol Panel N/A The ER provides explicit time-to-effect windows at line 383.

12. Benefits

# Description Result Comments
12.1 The section is derived from the ER Expected Benefits section 🟢 All nine benefit entries map to the ER’s H4 headings at lines 159, 167, 175, 181, 187, 195, 199, 203.
12.2 Key variables are [benefits_high], [benefits_medium], [benefits_low], [benefits_speculative] 🟢 All four spans present and populated at lines 544–561.
12.3 Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. 🟢 Each entry is the bare ER heading; no magnitudes, confidence intervals or funding notes carried.
12.4 Parenthetical content — including effect sizes, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. 🟢 No parentheses in any benefit entry; the ER’s “⚠️ Conflicted” flags are stripped.
12.5 If no items of a specific sub-section (high, medium, low, speculative) are present the respective <SPAN> is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. N/A All four benefit tiers carry at least one ER item.

13. Risks

# Description Result Comments
13.1 The section is derived from the ER Potential Risks & Side Effects section 🟢 All five risk entries map to the ER’s H4 headings at lines 233, 241, 247, 255, 259.
13.2 Key variables are [risks_high], [risks_medium], [risks_low], [risks_speculative] 🟢 All four spans present at lines 613–628.
13.3 Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. 🟢 Each entry is the bare ER heading; hazard ratios, Phase 1 details and the oil-carrier attribution are all omitted.
13.4 Parenthetical content — including frequencies, severity grades, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. 🟢 No parentheses in any risk entry.
13.5 If no items of a specific sub-section (high, medium, low, speculative) are present the respective <SPAN> is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. 🟢 The ER states “No risk reaches High”; line 613 correctly renders <span data-qrs-var="risks_high" style="display: none"></span> with no empty-state text.

14. Monitoring

# Description Result Comments
14.1 The section is derived from the ER Monitoring section 🟢 All six rows and the cadence come from the ER Monitoring Protocol & Defining Success section (ER lines 409–420).
14.2 All measurable/quantifiable biomarkers from the Monitoring section are listed 🟢 All six ER table biomarkers present: ethanolamine plasmalogen, Omega-3 Index, ALT, ferritin, fasting triglycerides, homocysteine.
14.3 [monitoring_cadence] is populated with the monitoring cadence/frequency derived from the ER Monitoring section. It is not left with placeholder text or empty. 🟢 Lines 732–736 condense ER line 411, retaining the 3-month, 6–12-month, 12-week, 6-month and anticoagulant 4-week checkpoints.

15. Qualitative Assessment

# Description Result Comments
15.1 The section is derived from the ER Monitoring section 🟢 All five items come from the ER’s “Qualitative markers worth tracking” list (ER lines 424–428).
15.2 All subjective/qualitative biomarkers from the Monitoring section are listed 🟢 All five ER qualitative markers present and verbatim.

Issues 14/09/2026 03:42

Pass rate 100.00%. No issues found.

Issues 14/09/2026 03:39

  1. 1.3 — At-A-Glance drops ER hedge: [at_a_glance] (QRS line 435) states “Human evidence rests on one form drawn from scallop, sea squirt and krill”, strengthening the ER’s “rests almost entirely on one subclass” (ER line 452) into an absolute claim that the ER’s own N-acyl-phosphatidylethanolamine and shark-liver-oil trials (ER lines 183–191) contradict.

Fixes 14/09/2026 03:39

  1. 1.3 — At-A-Glance hedge restored: Changed [at_a_glance] from “Human evidence rests on one form” to “Human evidence rests almost entirely on one form”, matching the ER’s own qualifier, and narrowed “Every study was industry-funded” to “Those studies were industry-funded” so the funding claim stays scoped to the trials just described; the lede remains within the 60-word budget at 59 words.