Phosphatidylserine, a fat-like building block of nerve-cell membranes, is a supplement made from soy, sunflower or marine sources and sold to support memory and stress resilience. Older studies of a cattle-brain version, no longer sold, showed modest memory gains; studies of today’s plant-based form are mixed. Safety looks favorable at usual amounts. For longevity-focused adults it is a low-risk, low-cost option whose memory benefit is uncertain and probably small. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Blood pressure | No established target; track change from own baseline | Safety check: possible lowering |
| Body weight | No established target; track change from own baseline | Safety check: small gain in open-label use |
| MoCA score | No established target; track change from own baseline | Tracks memory and executive function |
| Pulse (with cholinesterase inhibitors) | Not specified in the ER | Own baseline to judge later changes |
| INR (with anticoagulants) | Not specified in the ER | Own baseline to judge later changes |
Cadence: Baseline before starting; blood pressure weekly for the first month and again at 3 months; weight and cognitive screening at 3 months, then every 6–12 months while use continues