Piceatannol, a plant compound related to resveratrol and richest in passion fruit seeds, is sold as a dietary supplement for longevity. Human evidence is thin: small, short trials, mostly backed by the extract's maker, report moister skin and fewer visible wrinkles in women with dry skin; broader health effects are unproven. Longer-life claims rest entirely on animal and cell research. Short-term use appears well tolerated; longer-term safety is unknown. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Fasting glucose | 75–90 mg/dL | Detects glucose lowering or hypoglycemia |
| Fasting insulin | 2–6 µIU/mL | Tracks insulin sensitivity response |
| HOMA-IR | Below 1.0 | Primary outcome in the metabolic trial |
| HbA1c | 4.8–5.4% | 3-month glucose average |
| Home blood pressure | Below 120/80 mmHg | Tracks reported blood pressure lowering |
| Resting heart rate | 50–70 beats/min | Tracks reported heart rate lowering |
| ALT and AST | Below 25 U/L each | Liver safety |
| eGFR | Above 90 mL/min/1.73 m² | Kidney clearance of conjugates |
| hs-CRP | Below 1.0 mg/L | Systemic inflammation |
| Skin hydration | No established target; track change from own baseline | Skin outcome with the most trial support |
Cadence: Baseline before starting; at 4 weeks (fasting glucose and home blood pressure); at 8–12 weeks (full baseline panel); then every 6–12 months during continued use