A natural relative of resveratrol from passion-fruit seeds, piceatannol is a strong antioxidant that touches many aging and metabolism pathways in the lab. Human evidence is thin: the most repeatable finding is modest improvement in skin moisture and fine wrinkles. It is well tolerated at low doses, but long-term safety is untested. (Full Review)

Protocol

Dose

10–100 mg/day

10 mg skin, 20 mg metabolic, up to 100 mg sirtuin; no established optimal dose

Source

Passion-fruit seed

Piceatannol from Passiflora edulis seed, sometimes gamma-cyclodextrin-complexed for absorption

Timing

Once daily, with food

Evening or with/after a meal; 20 mg may be split twice daily for the short half-life

Time to effect

Skin

4–8 weeks

Hydration and wrinkle changes over 8-week trials

Metabolic

4–8 weeks

Insulin and blood-pressure changes

Sirtuin

~1 week

Blood SIRT1 changes at 100 mg/day

Benefits

Medium: Skin hydration and wrinkle reduction

Low: Insulin sensitivity and glycemic control; blood pressure and heart rate reduction; SIRT1 activation and fat metabolism

Speculative: Antioxidant and anti-inflammatory activity; cardiovascular and endothelial protection; anticancer and chemopreventive potential; neuroprotection

Contraindications

Pregnancy or breastfeeding

Hormone-sensitive cancers

Bleeding disorders or scheduled surgery

Children

Key Interactions

Anticoagulant and antiplatelet drugs (warfarin, apixaban, clopidogrel, aspirin)

Antidiabetic drugs (metformin, sulfonylureas, insulin)

Antihypertensive drugs (ACE inhibitors, calcium-channel blockers)

Over-the-counter medications (NSAIDs, aspirin)

Supplements with blood-thinning or additive effects (fish oil, vitamin E, ginkgo, garlic, resveratrol, quercetin)

CYP-metabolized drugs

Risk & Side Effects

Low: Mild gastrointestinal and transient adverse events

Speculative: Increased bleeding tendency; estrogenic activity; drug-metabolizing enzyme inhibition; unknown long-term safety and genotoxicity signals; immune modulation via Syk inhibition

Monitoring

Marker	Target	Why
Fasting insulin	2–6 µU/mL	Primary metabolic target
Fasting glucose	75–90 mg/dL	Main studied metabolic effect
HbA1c	< 5.4%	3-month average blood sugar
Blood pressure	< 120/80 mmHg	Reduced in overweight men
Resting heart rate	50–70 bpm	Fell alongside blood pressure
Lipid panel (LDL-C, HDL-C, triglycerides)	Triglycerides < 100 mg/dL; HDL-C > 50 mg/dL	Cardiovascular context
hs-CRP	< 1.0 mg/L	Tracks inflammation
ALT / AST (liver enzymes)	ALT < 25 U/L (men), < 20 U/L (women)	Basic safety given hepatic metabolism

Cadence: Baseline before starting, recheck at ~8 weeks, then every 6–12 months if continued; home blood-pressure checks weekly to monthly

Qualitative Assessment

Energy levels and perceived vigor through the day
Skin hydration, smoothness, and appearance
Absence of new bruising or bleeding
General well-being and mood stability

Piceatannol for Health & Longevity

Protocol

Benefits

Risk & Side Effects

Monitoring

Qualitative Assessment