Poly-γ-glutamic acid, the sticky substance in fermented soybeans, is a dietary supplement studied for immune, calcium and blood-sugar effects. Evidence is small and largely company-generated: one controlled study saw more early precancerous changes of the cervix clear; short studies suggest it may help calcium absorption and soften blood-sugar rises after starchy meals. The main risk is a rare, serious allergic reaction starting hours after a dose. Long-term value remains uncertain. (Full Review)
| Marker | Target | Why |
|---|---|---|
| HbA1c | 4.8–5.3% | Long-term glucose control |
| Fasting glucose | 75–90 mg/dL | Baseline glycemia |
| LDL cholesterol | Below 100 mg/dL | Cholesterol signal |
| Serum calcium | 9.2–10.0 mg/dL | Hypercalcemia safety check |
| 25-hydroxyvitamin D | 40–60 ng/mL | Calcium absorption depends on it |
| Bone mineral density (T-score) | Above −1.0 | Bone outcome of the calcium strategy |
| NK cell activity | No established target; track change from own baseline | Immune response marker |
| Cervical cytology and high-risk HPV | Normal cytology and HPV-negative | Lesion regression and viral clearance |
| Skin-prick or basophil activation test to γ-PGA | Negative | Allergy screen |
Cadence: Symptom check at 1 week; labs at 8–12 weeks, then every 6–12 months during use; cervical cytology and HPV every 6–12 months for CIN 1 (low-grade precancerous cell changes); bone density after 1–2 years.