A daily capsule of concentrated pomegranate compounds. Its most reliable effects are a modest fall in blood pressure and lower markers of inflammation, largest in those starting with raised readings. Cholesterol changes are small and inconsistent. Safety is reassuring; loose stools at high doses are the main problem. About one in ten cannot access the cell-renewal effects. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Home systolic blood pressure | 110–120 mmHg | Primary and best-evidenced endpoint |
| Home diastolic blood pressure | 65–80 mmHg | Detects additive hypotension when stacked with medication |
| High-sensitivity C-reactive protein | Below 0.5 mg/L | Tracks the inflammation signal with the strongest pooled evidence |
| Interleukin-6 | Below 1.5 pg/mL | More sensitive than C-reactive protein; moved reliably in the 55–70 age trial |
| Apolipoprotein B | Below 80 mg/dL | Confirms whether lipid expectations are being met, which pooled data suggest they will not be |
| Oxidized low-density lipoprotein | Below 60 U/L | Mechanistically the marker pomegranate moves most consistently |
| Fasting glucose | 75–86 mg/dL | Detects the small glycemic effect and rules out drift |
| Glycated hemoglobin | Below 5.4% | Three-month glucose average, insensitive to single-day variation |
| Ferritin | 50–150 ng/mL (women), 50–200 ng/mL (men) | Catches the tannin-mediated iron absorption risk |
| Alanine aminotransferase | Below 25 U/L (men), below 20 U/L (women) | Confirms no liver signal; pooled data suggest improvement rather than harm |
| Prostate-specific antigen | No established target; change from personal baseline and doubling time | Relevant only to men with a prostate cancer history |
| Urinary urolithin profile | No established range; producer or non-producer status | Determines whether the metabolite-dependent benefits are accessible at all |
Cadence: Weekly blood pressure for four weeks, then monthly; fasting panel repeated at 12 weeks, then every 6–12 months; ferritin annually for menstruating women, endurance athletes, and vegetarians.