A lab-made peptide, given by injection on demand, that acts on the brain to raise sexual desire and arousal rather than blood flow. Approved for premenopausal women with distressing low desire and used off-label in men. Benefits are real but small and overlap heavily with placebo; nausea, flushing, and headache are common. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Blood pressure | ~110–125 / 70–80 mmHg | Transiently raised; confirm control before and during use |
| Resting heart rate | 50–70 bpm | Transient decrease reported; baseline aids interpretation |
| Skin and moles | No new or changing pigmented lesions | Melanocyte stimulation can darken skin and moles |
| eGFR | >90 mL/min/1.73m² | Partly cleared by the kidneys |
Cadence: Blood pressure before initiation and after the first one or two doses, then periodically; skin and mole review at baseline and at least annually, with more frequent checks in frequent users.