A concentrated amaranth-leaf powder whose activity comes almost entirely from nitrate, which the body turns into nitric oxide, the signal that widens blood vessels. It reliably raises the body's nitrate supply; what follows is much less settled. Evidence for this extract is thin and pulls both ways, most likely because servings supply well under the amount linked to benefit. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Resting blood pressure | 110–120 / 70–78 mmHg | Primary vascular endpoint and the main safety limit |
| Orthostatic blood pressure change | Systolic fall under 10 mmHg on standing | Detects excessive additive vasodilation before fainting occurs |
| Serum potassium | 4.0–4.5 mmol/L | The extract is roughly 14% potassium, which stacks with potassium-retaining drugs |
| Estimated glomerular filtration rate | Above 90 mL/min/1.73 m² | Nitrate is cleared renally, so filtration governs exposure |
| Plasma or salivary nitrite | No established target; track change from the individual's own baseline | Confirms the nitrate-to-nitrite conversion step is actually working |
| Thyroid-stimulating hormone | 0.5–2.0 mIU/L | Screens the theoretical iodide-competition effect on thyroid output |
| 24-hour urinary oxalate | Below 40 mg/24 h | Addresses the unverified oxalate content of amaranth-derived material |
Cadence: Home blood pressure daily for the first two weeks, then weekly. Serum potassium and kidney filtration at 6 weeks, then every 6–12 months on continued daily use. Thyroid-stimulating hormone annually only with existing thyroid disease.