An herb-derived plant compound with strong free-radical-quenching and inflammation-calming actions in the lab. The most credible human signals are easing mild seasonal allergy symptoms and lowering inflammation and oxidative-stress markers; joint comfort, attention, and calm are weaker. Studies are small, often using whole-herb extracts. Low-risk and low-cost. (Full Review)
| Marker | Target | Why |
|---|---|---|
| hs-CRP | < 1.0 mg/L | Tracks systemic inflammation, the main pathway rosmarinic acid acts on |
| INR | Per anticoagulation target (e.g., 2.0–3.0 on warfarin) | Detects any additive blood-thinning effect when combined with warfarin |
| Blood pressure | < 120/80 mmHg | Screens for additive blood-pressure lowering when combined with antihypertensives |
| F2-isoprostanes (urinary) | Lower is better (assay-specific) | Direct marker of oxidative stress shown to fall with a rosmarinic-acid-rich extract |
| Fasting glucose | 70–85 mg/dL | Optional, for those exploring metabolic support given preclinical anti-diabetic signals |
Cadence: For most users, reassess the target symptom at 4 weeks and again at 8–16 weeks; for those on anticoagulants, check clotting status (e.g., INR if on warfarin) at 2–4 weeks after starting and after any dose change, then every 3–6 months.