Selank is a stabilised version of a natural immune-signalling peptide, registered in Russia as a nasal treatment for anxiety. Its most consistently reported effect is symptom reduction in people with diagnosed anxiety, without reported drowsiness, memory dulling, or dependence. Effects on mood, drive, and inflammation rest on thinner evidence. Outside Russia no approved product exists; long-term human data are absent. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Generalized Anxiety Disorder 7-item score (GAD-7) | 0-4 | Quantifies the primary target symptom |
| Perceived Stress Scale (PSS-10) | Below 14 | Captures subjective stress load, which anxiety scales miss |
| High-sensitivity C-reactive protein (hs-CRP) | Below 1.0 mg/L, ideally below 0.5 mg/L | General marker of body-wide inflammation; the most accessible read on the claimed immune-modulating effect |
| Interleukin-6 (IL-6) | Below 1.5 pg/mL | A signalling protein released by immune cells that Selank has been reported to shift in both directions |
| Complete blood count with differential (CBC) | Lymphocytes 20-40% of white cells; neutrophil-to-lymphocyte ratio below 2.0 | Detects immune shifts and screens for occult infection before an immune-active peptide is introduced |
| Comprehensive metabolic panel with liver enzymes (CMP, including ALT and AST) | Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) 10-26 U/L | Baseline liver and kidney function, essential before any non-pharmaceutical injectable |
| Thyroid-stimulating hormone (TSH) with free thyroxine (free T4) | TSH 0.5-2.0 mIU/L; free T4 in the mid-to-upper reference range | Thyroid dysfunction is a common, treatable cause of anxiety and fatigue that Selank would mask rather than correct |
| Ferritin | 50-150 ng/mL in women; 50-200 ng/mL in men | Depleted iron stores reproduce the fatigue and low drive Selank is used for |
| 25-hydroxyvitamin D | 40-60 ng/mL | Low status is associated with low mood and impaired immune regulation, both relevant to the claimed mechanism |
| Fasting glucose and fasting insulin | Glucose 75-85 mg/dL; insulin 2-5 µIU/mL | Blood-sugar instability produces symptoms indistinguishable from anxiety; animal work reports Selank affects glucose and lipids |
| Morning serum cortisol | 10-15 µg/dL at 8 a.m. | Objective read on the stress-hormone axis Selank is claimed to buffer |
Cadence: Full baseline panel and documented symptom score before the first dose; core panel repeated at the end of the first course (day 14 to 30), again at 3 months where courses are being repeated, then every 6 to 12 months across repeated cycles; symptom scores recorded weekly during a course.