A laboratory-made copy of a human repair protein the body uses to wake resting hair follicles. No trial has tested it on a human scalp, and the protein is far too large to cross unbroken skin. Known harms are minor and local; the real cost is a hair cycle spent finding out, at ten times the price. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Ferritin | 70–100 ng/mL | Iron stores gate entry into the growth phase |
| 25-hydroxyvitamin D | 40–60 ng/mL | Receptor is required for follicle cycling |
| TSH | 0.5–2.0 mIU/L | Thyroid dysfunction causes diffuse shedding |
| Plasma zinc | 90–120 µg/dL | Deficiency produces brittle hair and shedding |
| High-sensitivity CRP | <1.0 mg/L | Flags scalp or systemic inflammation confounding response |
| Free testosterone and DHT | No established target for topical growth-factor use; track against the individual's own baseline | Establishes whether an androgen driver is present and untreated |
| Marked-area hair density | ≥10% gain over baseline at 6 months | The actual endpoint the serum claims |
Cadence: Laboratory panel and standardised photographs at baseline; panel repeated at 3 months if any value was abnormal, otherwise at 6–12 months; photography at 4 and 6 months, then every 6 months; weekly scalp inspection for irritation through month one.